It's not necessarily all about the delivery in Huntington's disease.

Abstract:

:Existing models of Huntington's disease posit that deficits in BDNF delivery to the striatum contribute to atrophy and motor impairment. In this issue of Neuron, Plotkin et al. (2014) show that BDNF delivery is normal but downstream signaling via TrkB and p75 is impaired, leading to corticostriatal synaptic dysfunction.

journal_name

Neuron

journal_title

Neuron

authors

Parsons MP,Raymond LA

doi

10.1016/j.neuron.2014.06.009

subject

Has Abstract

pub_date

2014-07-02 00:00:00

pages

6-8

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(14)00531-5

journal_volume

83

pub_type

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