Abstract:
:Existing models of Huntington's disease posit that deficits in BDNF delivery to the striatum contribute to atrophy and motor impairment. In this issue of Neuron, Plotkin et al. (2014) show that BDNF delivery is normal but downstream signaling via TrkB and p75 is impaired, leading to corticostriatal synaptic dysfunction.
journal_name
Neuronjournal_title
Neuronauthors
Parsons MP,Raymond LAdoi
10.1016/j.neuron.2014.06.009subject
Has Abstractpub_date
2014-07-02 00:00:00pages
6-8issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(14)00531-5journal_volume
83pub_type
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