Abstract：
:Microglia are the immune cells of the brain. Here we show a massive infiltration of highly ramified and elongated microglia within the core of amyloid plaques in transgenic mouse models of Alzheimer's disease (AD). Many of these cells originate from the bone marrow, and the beta-amyloid-40 and -42 isoforms are able to trigger this chemoattraction. These newly recruited cells also exhibit a specific immune reaction to both exogenous and endogenous beta-amyloid in the brain. Creation of a new AD transgenic mouse that expresses the thymidine kinase protein under the control of the CD11b promoter allowed us to show that blood-derived microglia and not their resident counterparts have the ability to eliminate amyloid deposits by a cell-specific phagocytic mechanism. These bone marrow-derived microglia are thus very efficient in restricting amyloid deposits. Therapeutic strategies aiming to improve their recruitment could potentially lead to a new powerful tool for the elimination of toxic senile plaques.
journal_name
Neuronjournal_title
Neuronauthors
Simard AR,Soulet D,Gowing G,Julien JP,Rivest Sdoi
10.1016/j.neuron.2006.01.022subject
Has Abstractpub_date
2006-02-16 00:00:00pages
489-502issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(06)00075-4journal_volume
49pub_type
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