Cell-specific alternative splicing increases calcium channel current density in the pain pathway.

abstract：:Voluntary spatial attention concentrates neural resources at the attended location. Here, we examined the effects of spatial attention on spatial position selectivity in humans. We measured population receptive fields (pRFs) using high-field functional MRI (fMRI) (7T) while subjects performed an attention-demanding ta...

journal_title：Neuron

authors： Klein BP,Harvey BM,Dumoulin SO

更新日期：2014-10-01 00:00:00

abstract：:Expression of aversive memories is key for survival, but the underlying brain mechanisms are not fully understood. Medial habenular (MHb) axons corelease glutamate and acetylcholine onto target postsynaptic interpeduncular (IPN) neurons, but their role in aversive memories has not been addressed so far. We found that ...

journal_title：Neuron

authors： Soria-Gómez E,Busquets-Garcia A,Hu F,Mehidi A,Cannich A,Roux L,Louit I,Alonso L,Wiesner T,Georges F,Verrier D,Vincent P,Ferreira G,Luo M,Marsicano G

更新日期：2015-10-21 00:00:00

abstract：:In the developing mammalian retina, spontaneous waves of action potentials are present in the ganglion cell layer weeks before vision. These waves are known to be generated by a synaptically connected network of amacrine cells and retinal ganglion cells, and exhibit complex spatiotemporal patterns, characterized by sh...

journal_title：Neuron

authors： Feller MB,Butts DA,Aaron HL,Rokhsar DS,Shatz CJ

更新日期：1997-08-01 00:00:00

abstract：:Injection of inositol 1,4,5 trisphosphate (InsP3) into Limulus ventral photoreceptors elevates the concentration of intracellular calcium ions and as a consequence depolarizes the photoreceptor. This InsP3-induced elevation can be inhibited by a prior injection of calcium or InsP3 delivered 1 s earlier. Recovery from ...

journal_title：Neuron

authors： Payne R,Flores TM,Fein A

更新日期：1990-04-01 00:00:00

abstract：:Although nitric oxide (NO) is produced by discrete groups of neurons in the brain, participation of NO in premotor structures directly involved in reflexively evoked, sensory-motor functions has not been demonstrated so far. We now show that NO is a physiological mediator in the generation of a specific motor response...

journal_title：Neuron

authors： Moreno-López B,Escudero M,Delgado-Garcia JM,Estrada C

更新日期：1996-10-01 00:00:00

abstract：:Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose and many neuropsychiatric comorbidities. Uncovering the mechanisms responsible for pain-induced negative affect is critical in addressing these comorbid outcomes...

journal_title：Neuron

authors： Massaly N,Copits BA,Wilson-Poe AR,Hipólito L,Markovic T,Yoon HJ,Liu S,Walicki MC,Bhatti DL,Sirohi S,Klaas A,Walker BM,Neve R,Cahill CM,Shoghi KI,Gereau RW 4th,McCall JG,Al-Hasani R,Bruchas MR,Morón JA

更新日期：2019-05-08 00:00:00

abstract：:In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP)...

journal_title：Neuron

authors： Dragoi G,Harris KD,Buzsáki G

更新日期：2003-08-28 00:00:00

abstract：:Olfactory sensory neurons (OSNs) form synapses with local interneurons and second-order projection neurons to form stereotyped olfactory glomeruli. This primary olfactory circuit is hard-wired through the action of genetic cues. We asked whether individual glomeruli have the capacity for stimulus-evoked plasticity by ...

journal_title：Neuron

authors： Sachse S,Rueckert E,Keller A,Okada R,Tanaka NK,Ito K,Vosshall LB

更新日期：2007-12-06 00:00:00

abstract：:Neuromodulators are important regulators of synaptic transmission throughout the brain. At the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect transmission not only by changing neurotransmitter release probability, but also by shaping short-term plasticity (STP). Indeed, changes in STP are ...

journal_title：Neuron

authors： Burke KJ Jr,Keeshen CM,Bender KJ

更新日期：2018-09-05 00:00:00

abstract：:AMPA receptors are thought to be a tetrameric assembly of the subunits GluR1-4. We have examined whether two coexpressed subunits (GluR1/2) combine at random to form channels, or preferentially assemble with a specific stoichiometry and spatial configuration. The subunits carried markers controlling ion permeation and...

journal_title：Neuron

authors： Mansour M,Nagarajan N,Nehring RB,Clements JD,Rosenmund C

更新日期：2001-12-06 00:00:00

abstract：:To clarify the organization of motor representations in posterior parietal cortex, we test how three motor variables (body side, body part, cognitive strategy) are coded in the human anterior intraparietal cortex. All tested movements were encoded, arguing against strict anatomical segregation of effectors. Single uni...

journal_title：Neuron

authors： Zhang CY,Aflalo T,Revechkis B,Rosario ER,Ouellette D,Pouratian N,Andersen RA

更新日期：2017-08-02 00:00:00

abstract：:The online maintenance and manipulation of information in working memory (WM) is essential for guiding behavior based on our goals. Understanding how WM alters sensory processing in pursuit of different behavioral objectives is therefore crucial to establish the neural basis of our goal-directed behavior. Here we show...

journal_title：Neuron

authors： Bahmani Z,Daliri MR,Merrikhi Y,Clark K,Noudoost B

更新日期：2018-02-21 00:00:00

abstract：:Perception of the thermal environment begins with the activation of peripheral thermosensory neurons innervating the body surface. To understand how temperature is represented in vivo, we used genetically encoded calcium indicators to measure temperature-evoked responses in hundreds of neurons across the trigeminal ga...

journal_title：Neuron

authors： Yarmolinsky DA,Peng Y,Pogorzala LA,Rutlin M,Hoon MA,Zuker CS

更新日期：2016-12-07 00:00:00

abstract：:We used fear conditioning, which is known to alter synaptic efficacy in lateral amygdala (LA), to study molecular mechanisms underlying long-term memory. Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated with GRB2 in LA significantly more in conditioned than in control rat...

journal_title：Neuron

authors： Lamprecht R,Farb CR,LeDoux JE

更新日期：2002-11-14 00:00:00

abstract：:GABA, the major inhibitory neurotransmitter in the mammalian brain, binds to GABAA receptors, which form chloride ion channels. The predicted structure of the GABAA receptor places a consensus phosphorylation site for cAMP-dependent protein kinase (PKA) on an intracellular domain of the channel. Phosphorylation by var...

journal_title：Neuron

authors： Porter NM,Twyman RE,Uhler MD,Macdonald RL

更新日期：1990-12-01 00:00:00

abstract：:Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies. ...

journal_title：Neuron

authors： Hyman BT

更新日期：2014-06-18 00:00:00

abstract：:Terminal Schwann cells overlying the neuromuscular junction sprout elaborate processes upon muscle denervation. We show here that motor axons use these processes as guides/substrates during regeneration; in so doing, they escape the confines of endplates and grow between endplates to generate polyneuronal innervation....

journal_title：Neuron

authors： Son YJ,Thompson WJ

更新日期：1995-01-01 00:00:00

abstract：:In order to deal effectively with danger, it is imperative to know about it. This is what nociceptors do--these primary sensory neurons are specialized to detect intense stimuli and represent, therefore, the first line of defense against any potentially threatening or damaging environmental inputs. By sensing noxious ...

journal_title：Neuron

authors： Woolf CJ,Ma Q

更新日期：2007-08-02 00:00:00

abstract：:Neuroscience is an exciting and vibrant field, but building an academic career is not always easy. What are critical success indicators? Which tools help talented young neuroscientists conquer the challenges? In this NeuroView, we discuss instruments and steps that can help people progress through the ranks. ...

journal_title：Neuron

authors： Joëls M,Hoogenraad CC,Poirazi P,Di Luca M

更新日期：2015-05-06 00:00:00

abstract：:For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ...

journal_title：Neuron

authors： McAllister AK,van de Water J

更新日期：2009-10-15 00:00:00

abstract：:Auditory receptor cells rely on mechanically gated channels to transform sound stimuli into neural activity. Several TRP channels have been implicated in Drosophila auditory transduction, but mechanistic studies have been hampered by the inability to record subthreshold signals from receptor neurons. Here, we develop ...

journal_title：Neuron

authors： Lehnert BP,Baker AE,Gaudry Q,Chiang AS,Wilson RI

更新日期：2013-01-09 00:00:00

abstract：:Glial cells respond to neuronal activation and release neuroactive molecules (termed "gliotransmitters") that can affect synaptic activity and modulate plasticity. In this study, we used molecular genetic tools, ultra-structural microscopy, and electrophysiology to assess the role of brain-derived neurotrophic factor ...

journal_title：Neuron

authors： Vignoli B,Battistini G,Melani R,Blum R,Santi S,Berardi N,Canossa M

更新日期：2016-11-23 00:00:00

abstract：:Each residue in and flanking the M2 membrane-spanning segment of the alpha subunit, from Glu-241 to Glu-262, was mutated to cysteine, and the mutant subunits were expressed together with wild-type beta, gamma, and delta subunits in Xenopus oocytes. Cysteines substituted for Glu-262, Leu-258, Val-255, Ser-252, Leu-251,...

journal_title：Neuron

authors： Akabas MH,Kaufmann C,Archdeacon P,Karlin A

更新日期：1994-10-01 00:00:00

abstract：:In the developing nervous system, neurons are generated at sites distant from their ultimate location. In the vertebrate CNS, neurons utilize distinct migration strategies to reach their ultimate residence. This review discusses the contribution of tangential migration to the architectural development of the cerebral ...

journal_title：Neuron

authors： Maricich SM,Gilmore EC,Herrup K

更新日期：2001-08-02 00:00:00

abstract：:Binding between DIP and Dpr neuronal recognition proteins has been proposed to regulate synaptic connections between lamina and medulla neurons in the Drosophila visual system. Each lamina neuron was previously shown to express many Dprs. Here, we demonstrate, by contrast, that their synaptic partners typically expres...

journal_title：Neuron

authors： Cosmanescu F,Katsamba PS,Sergeeva AP,Ahlsen G,Patel SD,Brewer JJ,Tan L,Xu S,Xiao Q,Nagarkar-Jaiswal S,Nern A,Bellen HJ,Zipursky SL,Honig B,Shapiro L

更新日期：2018-12-19 00:00:00

abstract：:Mapping of the chromosomal location of genes essential for sweet and bitter taste and identification of the relevant G protein-coupled receptors reveals unanticipated complexity in taste signaling pathways. The distribution of sweet and bitter receptors suggests complete cellular segregation of these taste modalities....

journal_title：Neuron

authors： Lewcock JW,Reed RR

更新日期：2001-08-30 00:00:00

abstract：:Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus...

journal_title：Neuron

authors： Woods NI,Stefanini F,Apodaca-Montano DL,Tan IMC,Biane JS,Kheirbek MA

更新日期：2020-07-08 00:00:00

abstract：:At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic nerve to the brain. Available strategies of promoting axon regeneration act on only some of these types. Here we tested the hypothesis that overexpressing developmentally important transcription factors in adult RGCs could repr...

journal_title：Neuron

authors： Norsworthy MW,Bei F,Kawaguchi R,Wang Q,Tran NM,Li Y,Brommer B,Zhang Y,Wang C,Sanes JR,Coppola G,He Z

更新日期：2017-06-21 00:00:00

abstract：:The MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin prep...

journal_title：Neuron

authors： Bartsch U,Bandtlow CE,Schnell L,Bartsch S,Spillmann AA,Rubin BP,Hillenbrand R,Montag D,Schwab ME,Schachner M

更新日期：1995-12-01 00:00:00

abstract：:Kainate receptors signal through both ionotropic and metabotropic pathways. The high-affinity subunits, GluK4 and GluK5, are unique among the five receptor subunits, as they do not form homomeric receptors but modify the properties of heteromeric assemblies. Disruption of the Grik4 gene locus resulted in a significant...

journal_title：Neuron

authors： Fernandes HB,Catches JS,Petralia RS,Copits BA,Xu J,Russell TA,Swanson GT,Contractor A

更新日期：2009-09-24 00:00:00