Heteromeric AMPA receptors assemble with a preferred subunit stoichiometry and spatial arrangement.

abstract：:The forebrain is one of most complex cellular structures known. Two phenomena that enable this complexity are tangential migrations that mix neurons from distinct progenitor fields, and axon guidance across intervening, noninnervated fields. A new paper in Cell by López-Bendito et al. has discovered the convergence of...

journal_title：Neuron

authors： Maroof AM,Anderson SA

更新日期：2006-04-20 00:00:00

abstract：:Social environment modulates learning through unknown mechanisms. Here, we report that a pheromone mixture that signals overcrowding inhibits C. elegans from learning to avoid pathogenic bacteria. We find that learning depends on the balanced signaling of two insulin-like peptides (ILPs), INS-16 and INS-4, which act r...

journal_title：Neuron

authors： Wu T,Duan F,Yang W,Liu H,Caballero A,Fernandes de Abreu DA,Dar AR,Alcedo J,Ch'ng Q,Butcher RA,Zhang Y

更新日期：2019-12-18 00:00:00

abstract：:Telling time and anticipating when external events will happen is among the most important tasks the brain performs. Yet the neural mechanisms underlying timing remain elusive. One theory proposes that timing is a general and intrinsic computation of cortical circuits. We tested this hypothesis using electrical and op...

journal_title：Neuron

authors： Goel A,Buonomano DV

更新日期：2016-07-20 00:00:00

abstract：:Homomeric assembly of Kir5.1, an inward-rectifying K+ channel subunit, is believed to be nonfunctional, although the subunit exists abundantly in the brain. We show that HEK293T cells cotransfected with Kir5.1 and PSD-95 exhibit a Ba(2+)-sensitive inward-rectifying K+ current. Kir5.1 coexpressed with PSD-95 located on...

journal_title：Neuron

authors： Tanemoto M,Fujita A,Higashi K,Kurachi Y

更新日期：2002-04-25 00:00:00

abstract：:Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...

journal_title：Neuron

authors： Lammel S,Ion DI,Roeper J,Malenka RC

更新日期：2011-06-09 00:00:00

abstract：:We have cloned a Kv2 potassium channel from squid optic lobe termed sqKv2. Multiple overlapping sqKv2 cDNA clones differed from one another at specific positions by purine transitions. To test whether the purine transitions were generated by RNA editing, we compared a 360 nucleotide genomic sequence with corresponding...

journal_title：Neuron

authors： Patton DE,Silva T,Bezanilla F

更新日期：1997-09-01 00:00:00

abstract：:The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produc...

journal_title：Neuron

authors： Katz PS

更新日期：1996-02-01 00:00:00

abstract：:Synapses are lost during developmental synapse elimination. Until now, it has been impossible to follow elimination in the entirety of any neuron's branches and synapses. Using transgenic mice in which one or two of a muscle's motoneurons express variants of GFP, Keller-Peck et al. show in this issue of Neuron that el...

journal_title：Neuron

authors： Thompson WJ

更新日期：2001-08-16 00:00:00

abstract：:Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data f...

journal_title：Neuron

authors： Geschwind DH

更新日期：2003-10-30 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) has been described as a biochemical switch that is turned on by increases in intracellular calcium to mediate synaptic plasticity. Here, we show that reductions in CaMKII activity trigger persistent increases in intrinsic excitability. In spontaneously firing ves...

journal_title：Neuron

authors： Nelson AB,Gittis AH,du Lac S

更新日期：2005-05-19 00:00:00

abstract：:We constructed a recombinant baculovirus, A. californica nuclear polyhedrosis virus, containing the Drosophila Shaker H4 K+ channel cDNA under control of the polyhedrin promoter. When infected with this recombinant baculovirus, the cell line Sf9, derived from the army-worm caterpillar S. frugiperda, expresses fully fu...

journal_title：Neuron

authors： Klaiber K,Williams N,Roberts TM,Papazian DM,Jan LY,Miller C

更新日期：1990-08-01 00:00:00

abstract：:We recently proposed that ciliary neurotrophic factor (CNTF) shares two receptor components with a generally acting cytokine, leukemia inhibitory factor (LIF), but that CNTF also requires a third receptor component (CNTFR alpha) that is mostly restricted to the nervous system in its expression. Here we demonstrate tha...

journal_title：Neuron

authors： Ip NY,McClain J,Barrezueta NX,Aldrich TH,Pan L,Li Y,Wiegand SJ,Friedman B,Davis S,Yancopoulos GD

更新日期：1993-01-01 00:00:00

abstract：:Visual attention has been classically described as a spotlight that enhances the processing of a behaviorally relevant object. However, in many situations, humans and animals must simultaneously attend to several relevant objects separated by distracters. To account for this ability, various models of attention have b...

journal_title：Neuron

authors： Niebergall R,Khayat PS,Treue S,Martinez-Trujillo JC

更新日期：2011-12-22 00:00:00

abstract：:Neuron B19 of Helisoma is selective in synaptogenesis. Presynaptic mechanisms underlying this selectivity were tested. Acetylcholine-sensitive assay cells were micromanipulated into contact with B19 somata to assess its secretory state. Prior to appropriate muscle target contact, spontaneous synaptic currents were det...

journal_title：Neuron

authors： Zoran MJ,Doyle RT,Haydon PG

更新日期：1991-01-01 00:00:00

abstract：:The brain must make sense of external stimuli to generate relevant behavior. We used a combination of in vivo approaches to investigate how the cerebellum processes sensory-related information. We found that the inferior olive encodes contexts of sensory-associated external cues in a graded manner, apparent in the pre...

journal_title：Neuron

authors： Gaffield MA,Bonnan A,Christie JM

更新日期：2019-05-22 00:00:00

abstract：:The serotonin system powerfully modulates physiology and behavior in health and disease, yet the circuit mechanisms underlying serotonin neuron activity are poorly understood. The major source of forebrain serotonergic innervation is from the dorsal raphe nucleus (DR), which contains both serotonin and GABA neurons. U...

journal_title：Neuron

authors： Weissbourd B,Ren J,DeLoach KE,Guenthner CJ,Miyamichi K,Luo L

更新日期：2014-08-06 00:00:00

abstract：:The directional selectivity of retinal ganglion cell responses represents a primitive pattern recognition that operates within a retinal neural circuit. The cellular origin and mechanism of directional selectivity were investigated by selectively eliminating retinal starburst amacrine cells, using immunotoxin-mediated...

journal_title：Neuron

authors： Yoshida K,Watanabe D,Ishikane H,Tachibana M,Pastan I,Nakanishi S

更新日期：2001-06-01 00:00:00

abstract：:Synapses have a limited pool of vesicles that are docked and primed for rapid release. In neuroendocrine cells, splice variants of the SNARE protein SNAP-25 and phosphorylation of SNAP-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate of vesicle depriming. Pre- and postt...

journal_title：Neuron

authors： Heidelberger R,Matthews G

更新日期：2004-02-05 00:00:00

abstract：:Glutamate receptors mediate the majority of rapid excitatory synaptic transmission in the central nervous system (CNS) and play important roles in synaptic plasticity and neuronal development. Recently, protein-protein interactions with the C-terminal domain of glutamate receptor subunits have been shown to be involve...

journal_title：Neuron

authors： Song I,Kamboj S,Xia J,Dong H,Liao D,Huganir RL

更新日期：1998-08-01 00:00:00

abstract：:Excessive grooming behaviors, cleansing rituals, and self-mutilation are important features of a range of neuropsychiatric diseases including obsessive compulsive (OC)-spectrum disorders. In this issue of Neuron, Greer and Capecchi (2002) report that Hoxb8 mutant mice exhibit this behavioral phenotype. These Hoxb8 mut...

journal_title：Neuron

authors： Graybiel AM,Saka E

更新日期：2002-01-03 00:00:00

abstract：:How primates perceive objects along with their detailed features remains a mystery. This ability to make fine visual discriminations depends upon a high-acuity analysis of spatial frequency (SF) along the visual hierarchy from V1 to inferotemporal cortex. By studying the transformation of SF across macaque parafoveal ...

journal_title：Neuron

authors： Lu Y,Yin J,Chen Z,Gong H,Liu Y,Qian L,Li X,Liu R,Andolina IM,Wang W

更新日期：2018-04-18 00:00:00

abstract：:To investigate the role of the entorhinal cortex in memory at a molecular level, we developed transgenic mice in which transgene expression was inducible and limited to the superficial layers of the medial entorhinal cortex, pre- and parasubiculum. We found that expression of a constitutively active mutant form of CaM...

journal_title：Neuron

authors： Yasuda M,Mayford MR

更新日期：2006-04-20 00:00:00

abstract：:According to economic theories, preference for one item over others reveals its rank value on a common scale. Previous studies identified brain regions encoding such values. Here we verify that these regions can valuate various categories of objects and further test whether they still express preferences when attentio...

journal_title：Neuron

authors： Lebreton M,Jorge S,Michel V,Thirion B,Pessiglione M

更新日期：2009-11-12 00:00:00

abstract：:Although animal studies provided significant insights in understanding the neural basis of learning and adaptation, they often cannot dissociate between different learning mechanisms due to the lack of verbal communication. To overcome this limitation, we examined the mechanisms of learning and its limits in a human i...

journal_title：Neuron

authors： Sakellaridi S,Christopoulos VN,Aflalo T,Pejsa KW,Rosario ER,Ouellette D,Pouratian N,Andersen RA

更新日期：2019-05-08 00:00:00

abstract：:The M current regulates neuronal excitability, with its amplitude resulting from high open probability modal M channel behavior. The M current is affected by changing intracellular calcium levels. It is proposed that internal calcium acts by regulating M channel modal gating. Intracellular application of a preactivate...

journal_title：Neuron

authors： Marrion NV

更新日期：1996-01-01 00:00:00

abstract：:An impressive body of research over the past 30 years has implicated the human cerebellum in a broad range of functions, including motor control, perception, language, working memory, cognitive control, and social cognition. The relatively uniform anatomy and physiology of the cerebellar cortex has given rise to the i...

journal_title：Neuron

authors： Diedrichsen J,King M,Hernandez-Castillo C,Sereno M,Ivry RB

更新日期：2019-06-05 00:00:00

abstract：:The neurotrophic proteins BDNF and NGF are related in their primary structures, and both have high- and low-affinity receptors on their responsive neurons. In this study, we investigate the extent to which these receptors can discriminate between BDNF and NGF. We found that a 1000-fold excess of the heterologous ligan...

journal_title：Neuron

authors： Rodriguez-Tébar A,Dechant G,Barde YA

更新日期：1990-04-01 00:00:00

abstract：:Genetic deletion of fragile X mental retardation protein (FMRP) has been shown to enhance mGluR-dependent long-term depression (LTD). Herein, we demonstrate that mGluR-LTD induces a transient, translation-dependent increase in FMRP that is rapidly degraded by the ubiquitin-proteasome pathway. Moreover, proteasome inhi...

journal_title：Neuron

authors： Hou L,Antion MD,Hu D,Spencer CM,Paylor R,Klann E

更新日期：2006-08-17 00:00:00

abstract：:The capsaicin receptor, TRPV1, is regulated by phosphatidylinositol-4,5-bisphosphate (PIP(2)), although the precise nature of this effect (i.e., positive or negative) remains controversial. Here, we reconstitute purified TRPV1 into artificial liposomes, where it is gated robustly by capsaicin, protons, spider toxins, ...

journal_title：Neuron

authors： Cao E,Cordero-Morales JF,Liu B,Qin F,Julius D

更新日期：2013-02-20 00:00:00

abstract：:Promises are one of the oldest human-specific psychological mechanisms fostering cooperation and trust. Here, we study the neural underpinnings of promise keeping and promise breaking. Subjects first make a promise decision (promise stage), then they anticipate whether the promise affects the interaction partner's dec...

journal_title：Neuron

authors： Baumgartner T,Fischbacher U,Feierabend A,Lutz K,Fehr E

更新日期：2009-12-10 00:00:00