Abstract:
:Perception of the thermal environment begins with the activation of peripheral thermosensory neurons innervating the body surface. To understand how temperature is represented in vivo, we used genetically encoded calcium indicators to measure temperature-evoked responses in hundreds of neurons across the trigeminal ganglion. Our results show how warm, hot, and cold stimuli are represented by distinct population responses, uncover unique functional classes of thermosensory neurons mediating heat and cold sensing, and reveal the molecular logic for peripheral warmth sensing. Next, we examined how the peripheral somatosensory system is functionally reorganized to produce altered perception of the thermal environment after injury. We identify fundamental transformations in sensory coding, including the silencing and recruitment of large ensembles of neurons, providing a cellular basis for perceptual changes in temperature sensing, including heat hypersensitivity, persistence of heat perception, cold hyperalgesia, and cold analgesia.
journal_name
Neuronjournal_title
Neuronauthors
Yarmolinsky DA,Peng Y,Pogorzala LA,Rutlin M,Hoon MA,Zuker CSdoi
10.1016/j.neuron.2016.10.021subject
Has Abstractpub_date
2016-12-07 00:00:00pages
1079-1092issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(16)30722-Xjournal_volume
92pub_type
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