Abstract：
:It has been hypothesized that the direction of synaptic weight change elicited by synaptic activity depends on the magnitude of the activity-dependent rise in intracellular Ca2+ concentration. Several aspects of this hypothesis were examined at the Schaffer collateral CA1 synapse, where both long-term depression (LTD) and long-term potentiation (LTP) can be elicited and are Ca2+ dependent. Brief tetanic stimulation, which normally generated LTP, could induce LTD when Ca2+ entry via NMDA receptors was limited either by moderate concentrations of D-APV or by voltage clamping cells at negative membrane potentials. Repetitive activation of voltage-dependent Ca2+ channels in the absence of afferent stimulation could also elicit an LTD that was Ca2+ dependent and was occluded by prior generation of homosynaptic LTD using prolonged low evidence that the minimal requirements for inducing LTD involve simply a transient influx of Ca2+ into the postsynaptic cell, via either NMDA receptors or voltage-dependent Ca2+ channels.
journal_name
Neuronjournal_title
Neuronauthors
Cummings JA,Mulkey RM,Nicoll RA,Malenka RCdoi
10.1016/s0896-6273(00)80102-6subject
Has Abstractpub_date
1996-04-01 00:00:00pages
825-33issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80102-6journal_volume
16pub_type
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