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Intersecting circuits generate precisely patterned retinal waves.

Abstract：

:The developing retina generates spontaneous glutamatergic (stage III) waves of activity that sequentially recruit neighboring ganglion cells with opposite light responses (ON and OFF RGCs). This activity pattern is thought to help establish parallel ON and OFF pathways in downstream visual areas. The circuits that produce stage III waves and desynchronize ON and OFF RGC firing remain obscure. Using dual patch-clamp recordings, we find that ON and OFF RGCs receive sequential excitatory input from ON and OFF cone bipolar cells (CBCs), respectively. This input sequence is generated by crossover circuits, in which ON CBCs control glutamate release from OFF CBCs via diffusely stratified inhibitory amacrine cells. In addition, neighboring ON CBCs communicate directly and indirectly through lateral glutamatergic transmission and gap junctions, both of which are required for wave initiation and propagation. Thus, intersecting lateral excitatory and vertical inhibitory circuits give rise to precisely patterned stage III retinal waves.

journal_name

Neuron

journal_title

Neuron

authors

Akrouh A,Kerschensteiner D

doi

10.1016/j.neuron.2013.05.012

subject

Has Abstract

pub_date

2013-07-24 00:00:00

pages

322-34

issue

2

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(13)00405-4

journal_volume

79

pub_type

杂志文章

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