Abstract：
:The amplitudes and kinetics of miniature excitatory synaptic currents (MESCs) in mammalian central neurons vary widely. It is unclear whether this variability occurs at each synapse or arises from differences among a heterogeneous population of synapses. Furthermore, it is not known how variability in these currents would affect their associated postsynaptic Ca2+ transients. To address these questions, we conducted simultaneous Ca2+ imaging and patch-clamp recordings from cultured cortical neurons and mapped individual MESCs to identified synapses displaying coincident dendritic miniature synaptic Ca2+ transients (MSCTs). Measurements of MSCTs at dendritic sites that displayed multiple events revealed that MSCT amplitude varied considerably at each site. Simultaneous measurement of MESCs and MSCTs at these sites indicated that variability in coincident synaptic currents contributes to the differences in Ca2+ transient amplitude. The ability of single synapses to exhibit variable output may enable them to engage intracellular signaling pathways at different levels of intracellular Ca2+.
journal_name
Neuronjournal_title
Neuronauthors
Murphy TH,Baraban JM,Wier WGdoi
10.1016/0896-6273(95)90073-xsubject
Has Abstractpub_date
1995-07-01 00:00:00pages
159-68issue
1eissn
0896-6273issn
1097-4199pii
0896-6273(95)90073-Xjournal_volume
15pub_type
杂志文章相关文献
NEURON文献大全abstract：:TRP and TRPL are two light-sensitive cation channel subunits required for the Drosophila photoresponse; however, our understanding of the identities, subunit composition, and function of the light-responsive channels is incomplete. To explain the residual photoresponse that remains in the trp mutant, a third TRP-relat...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81201-5
更新日期：2000-06-01 00:00:00
abstract：:In the long-range neuronal migration of adult mammals, young neurons travel from the subventricular zone to the olfactory bulb, a long journey (millimeters to centimeters, depending on the species). How can these neurons migrate through the dense meshwork of neuronal and glial processes of the adult brain parenchyma? ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.06.018
更新日期：2010-07-29 00:00:00
abstract：:Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excito...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(02)00631-1
更新日期：2002-03-14 00:00:00
abstract：:NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor-expressing cells, and the majority of native receptors are triheteromers containing two GluN1 and two different GluN2. In contrast to diheterome...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.01.035
更新日期：2014-03-05 00:00:00
abstract：:Rodents begin to use bilaterally coordinated, rhythmic sweeping of their vibrissae ("whisking") for environmental exploration around 2 weeks after birth. Whether (and how) the vibrissal control circuitry changes after birth is unknown, and the relevant premotor circuitry remains poorly characterized. Using a modified ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.11.010
更新日期：2013-01-23 00:00:00
abstract：:Neuropathic pain is caused by long-term modifications of neuronal function in the peripheral nervous system, the spinal cord, and supraspinal areas. Although functional changes in the forebrain are thought to contribute to the development of persistent pain, their significance and precise subcellular nature remain une...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.03.003
更新日期：2015-04-08 00:00:00
abstract：:Recent progress in neurophysiological recording has developed in two directions. One relies on multimicroelectrodes to study correlations in neuron firing. The other relies on sophisticated tasks to distinguish successive stages of neuronal processing. In this issue of Neuron, Shichinohe et al. take this second approa...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2009.05.018
更新日期：2009-06-11 00:00:00
abstract：:To characterize the role of rare complete human knockouts in autism spectrum disorders (ASDs), we identify genes with homozygous or compound heterozygous loss-of-function (LoF) variants (defined as nonsense and essential splice sites) from exome sequencing of 933 cases and 869 controls. We identify a 2-fold increase i...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.12.029
更新日期：2013-01-23 00:00:00
abstract：:Abnormally phosphorylated tau proteins (A68) are the building blocks of Alzheimer's disease (AD) paired helical filaments. The biological consequences of the conversion of normal adult tau to A68 remain unknown. Here we demonstrate that native A68 does not bind to microtubules (MTs), yet dephosphorylated A68 regains t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90057-x
更新日期：1993-06-01 00:00:00
abstract：:Recent binding studies in the central nervous system and other tissues provide evidence that the mammalian bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin-B (NMB), exert their numerous physiological effects through at least two different receptors. We describe the structure and expression of a c...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(91)90250-4
更新日期：1991-03-01 00:00:00
abstract：:Despite the best available medical treatments, many patients continue to be disabled by neurologic and psychiatric disorders, resulting in a large unmet need. Advances in imaging and neurophysiology over the last two decades have led to a reinterpretation of some neurologic and psychiatric conditions as primarily diso...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2013.01.020
更新日期：2013-02-06 00:00:00
abstract：:Terminal Schwann cells overlying the neuromuscular junction sprout elaborate processes upon muscle denervation. We show here that motor axons use these processes as guides/substrates during regeneration; in so doing, they escape the confines of endplates and grow between endplates to generate polyneuronal innervation....
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90246-5
更新日期：1995-01-01 00:00:00
abstract：:GABA(B) (gamma-aminobutyric acid type B) receptors are important for keeping neuronal excitability under control. Cloned GABA(B) receptors do not show the expected pharmacological diversity of native receptors and it is unknown whether they contribute to pre- as well as postsynaptic functions. Here, we demonstrate tha...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00345-2
更新日期：2001-07-19 00:00:00
abstract：:Movements are universally, sometimes frustratingly, variable. When such variability causes error, we typically assume that something went wrong during the movement. The same assumption is made by recent and influential models of motor control. These posit that the principal limit on repeatable performance is neuromusc...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.10.034
更新日期：2006-12-21 00:00:00
abstract：:The mesolimbic system is known to play a role in self-administration of opioids and psychostimulants. Although morphine and cocaine act by separate cellular mechanisms initially, the present study describes a common change in synaptic regulation of dopamine cells in the ventral tegmental area 1 week after termination ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80082-3
更新日期：1996-03-01 00:00:00
abstract：:During synaptic development, proteins aggregate at specialized pre- and postsynaptic structures. Mechanisms that mediate protein clustering at these sites remain unknown. To investigate this process, we analyzed synaptic targeting of a postsynaptic density protein, PSD-95, by expressing green fluorescent protein- (GFP...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80705-9
更新日期：1999-03-01 00:00:00
abstract：:A critical feature of neural networks is that they balance excitation and inhibition to prevent pathological dysfunction. How this is achieved is largely unknown, although deficits in the balance contribute to many neurological disorders. We show here that a microRNA (miR-101) is a key orchestrator of this essential f...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.11.017
更新日期：2016-12-21 00:00:00
abstract：:Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data f...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(03)00681-0
更新日期：2003-10-30 00:00:00
abstract：:Recent evidence has challenged the view that memories are made permanent by a consolidation process that happens just once and instead have suggested that memories are "re-consolidated" after reminders. The current findings of Morris et al. in this issue of Neuron suggest that reconsolidation may involve a complex int...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2006.04.017
更新日期：2006-05-04 00:00:00
abstract：:Ca(2+)-calmodulin (CaM) function was selectively disrupted in a specific subset of growth cones in transgenic Drosophila embryos in which a specific enhancer element drives the expression of the kinesin motor domain fused to a CaM antagonist peptide (kinesin-antagonist or KA, which blocks CaM binding to target protein...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90239-2
更新日期：1995-01-01 00:00:00
abstract：:Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGluR-dependent LTD. The increase in Arc/Arg3.1 translation requires e...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.05.023
更新日期：2008-07-10 00:00:00
abstract：:Visinin is a retinal cone cell-specific protein (molecular weight 24,000, pI 5.1). To investigate its function, visinin cDNA was isolated from a chick retinal lambda gt11 cDNA library, using anti-visinin serum. The beta-galactosidase-visinin fusion protein was used for purifying epitope-selected antibody. The purified...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90059-o
更新日期：1990-03-01 00:00:00
abstract：:Promises are one of the oldest human-specific psychological mechanisms fostering cooperation and trust. Here, we study the neural underpinnings of promise keeping and promise breaking. Subjects first make a promise decision (promise stage), then they anticipate whether the promise affects the interaction partner's dec...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.11.017
更新日期：2009-12-10 00:00:00
abstract：VIDEO ABSTRACT:The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.02.009
更新日期：2012-03-22 00:00:00
abstract：:Neuromodulators regulate circuits throughout the nervous system, and revealing the cell types and stimulus conditions controlling their release is vital to understanding their function. The effects of the neuromodulator nitric oxide (NO) have been studied in many circuits, including in the vertebrate retina, where it ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.09.047
更新日期：2018-12-05 00:00:00
abstract：:Both human speech and animal vocal signals contain frequency-modulated (FM) sounds. Although central auditory neurons that selectively respond to the direction of frequency modulation are known, the synaptic mechanisms underlying the generation of direction selectivity (DS) remain elusive. Here we show the emergence o...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.11.035
更新日期：2012-03-08 00:00:00
abstract：:The function of the CB2 cannabinoid receptor in the brain has long been a matter of debate. In this issue of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a cell-intrinsic hyperpolarization that controls self activity. ...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2016.05.012
更新日期：2016-05-18 00:00:00
abstract：:A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.09.027
更新日期：2008-10-09 00:00:00
abstract：:Visual information reaches the brain by way of a fine cable, the optic nerve. The million or so axons in the optic nerve represent an information bottleneck in the visual pathway-where the fewest number of neurons convey the visual scene. It has long been thought that to make the most of the optic nerve's limited capa...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2005.04.018
更新日期：2005-05-05 00:00:00
abstract：:Although nitric oxide (NO) is produced by discrete groups of neurons in the brain, participation of NO in premotor structures directly involved in reflexively evoked, sensory-motor functions has not been demonstrated so far. We now show that NO is a physiological mediator in the generation of a specific motor response...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80205-6
更新日期：1996-10-01 00:00:00
