Abstract：
:Neuromodulators regulate circuits throughout the nervous system, and revealing the cell types and stimulus conditions controlling their release is vital to understanding their function. The effects of the neuromodulator nitric oxide (NO) have been studied in many circuits, including in the vertebrate retina, where it regulates synaptic release, gap junction coupling, and blood vessel dilation, but little is known about the cells that release NO. We show that a single type of amacrine cell (AC) controls NO release in the inner retina, and we report its light responses, electrical properties, and calcium dynamics. We discover that this AC forms a dense gap junction network and that the strength of electrical coupling in the network is regulated by light through NO. A model of the network offers insights into the biophysical specializations leading to auto-regulation of NO release within the network.
journal_name
Neuronjournal_title
Neuronauthors
Jacoby J,Nath A,Jessen ZF,Schwartz GWdoi
10.1016/j.neuron.2018.09.047subject
Has Abstractpub_date
2018-12-05 00:00:00pages
1149-1162.e5issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30849-3journal_volume
100pub_type
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