A Self-Regulating Gap Junction Network of Amacrine Cells Controls Nitric Oxide Release in the Retina.

Abstract:

:Neuromodulators regulate circuits throughout the nervous system, and revealing the cell types and stimulus conditions controlling their release is vital to understanding their function. The effects of the neuromodulator nitric oxide (NO) have been studied in many circuits, including in the vertebrate retina, where it regulates synaptic release, gap junction coupling, and blood vessel dilation, but little is known about the cells that release NO. We show that a single type of amacrine cell (AC) controls NO release in the inner retina, and we report its light responses, electrical properties, and calcium dynamics. We discover that this AC forms a dense gap junction network and that the strength of electrical coupling in the network is regulated by light through NO. A model of the network offers insights into the biophysical specializations leading to auto-regulation of NO release within the network.

journal_name

Neuron

journal_title

Neuron

authors

Jacoby J,Nath A,Jessen ZF,Schwartz GW

doi

10.1016/j.neuron.2018.09.047

subject

Has Abstract

pub_date

2018-12-05 00:00:00

pages

1149-1162.e5

issue

5

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(18)30849-3

journal_volume

100

pub_type

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