Abstract:
:The function of the CB2 cannabinoid receptor in the brain has long been a matter of debate. In this issue of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a cell-intrinsic hyperpolarization that controls self activity.
journal_name
Neuronjournal_title
Neuronauthors
Quraishi SA,Paladini CAdoi
10.1016/j.neuron.2016.05.012subject
Has Abstractpub_date
2016-05-18 00:00:00pages
670-1issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(16)30172-6journal_volume
90pub_type
评论,杂志文章,评审相关文献
NEURON文献大全abstract::The mammalian genome has hundreds of nuclear-encoded tRNAs, but the contribution of individual tRNA genes to cellular and organismal function remains unknown. Here, we demonstrate that mutations in a neuronally enriched arginine tRNA, n-Tr20, increased seizure threshold and altered synaptic transmission. n-Tr20 expres...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.07.023
更新日期:2020-10-14 00:00:00
abstract::To investigate the structural determinants underlying transport by the glutamate transporter EAAT1, we mutated each of 24 highly conserved residues (P392 to Q415) to cysteine. A majority of these substituted cysteines react with the sulfhydryl-modifying reagent MTSEA, suggesting that they reside in an aqueous environm...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80666-2
更新日期:1998-12-01 00:00:00
abstract::The enteric nervous system (ENS) in vertebrates is derived mainly from vagal neural crest cells that enter the foregut and colonize the entire wall of the gastrointestinal tract. Failure to completely colonize the gut results in the absence of enteric ganglia (Hirschsprung's disease). Two signaling systems mediated by...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00730-x
更新日期:2003-12-04 00:00:00
abstract::Neural processing at most stages of the primate visual system is modulated by selective attention, such that behaviorally relevant information is emphasized at the expenses of irrelevant, potentially distracting information. The form of attention best understood at the cellular level is when stimuli at a given locatio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.04.007
更新日期:2007-04-19 00:00:00
abstract::The chemokine Cxcl12 binds Cxcr4 and Cxcr7 receptors to control cell migration in multiple biological contexts, including brain development, leukocyte trafficking, and tumorigenesis. Both receptors are expressed in the CNS, but how they cooperate during migration has not been elucidated. Here, we used the migration of...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.12.006
更新日期:2011-01-13 00:00:00
abstract::Hundreds of G protein-coupled receptors (GPCRs) and at least six GPCR kinases have been identified, but the only GPCR phosphatase that has been definitively demonstrated is the rhodopsin phosphatase encoded by the rdgC locus of Drosophila. Mutations in rdgC result in defects in termination of the light response and ca...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00538-4
更新日期:2001-12-20 00:00:00
abstract::It has been hypothesized that the direction of synaptic weight change elicited by synaptic activity depends on the magnitude of the activity-dependent rise in intracellular Ca2+ concentration. Several aspects of this hypothesis were examined at the Schaffer collateral CA1 synapse, where both long-term depression (LTD)...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80102-6
更新日期:1996-04-01 00:00:00
abstract::Microcircuits in different brain areas share similar architectural and biophysical properties with compact motor networks known as central pattern generators (CPGs). Consequently, CPGs have been suggested as valuable biological models for understanding of microcircuit dynamics and particularly, their synchronization. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.12.032
更新日期:2009-02-12 00:00:00
abstract::The ability to classify visual objects into discrete categories ("friend" versus "foe"; "edible" versus "poisonous") is essential for survival and is a fundamental cognitive function. The cortical substrates that mediate this function, however, have not been identified in humans. To identify brain regions involved in ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.01.032
更新日期:2006-03-02 00:00:00
abstract::Brain function is mediated by neural circuit connectivity, and elucidating the role of connections is aided by techniques to block their output. We developed cell-type-selective, reversible synaptic inhibition tools for mammalian neural circuits by leveraging G protein signaling pathways to suppress synaptic vesicle r...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.04.008
更新日期:2014-05-21 00:00:00
abstract::In neurons, posttranslational modification by palmitate regulates the trafficking and function of signaling molecules, neurotransmitter receptors, and associated synaptic scaffolding proteins. However, the enzymatic machinery involved in protein palmitoylation has remained elusive. Here, using biochemical assays, we s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.11.027
更新日期:2004-12-16 00:00:00
abstract::To survive, humans must estimate their own ability and the abilities of others. We found that, although people estimated their abilities on the basis of their own performance in a rational manner, their estimates of themselves were partly merged with the performance of others. Reciprocally, their ability estimates for...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.06.022
更新日期:2016-07-20 00:00:00
abstract::Careful functional dissection of mouse neuromuscular junctions (NMJs) formed in the absence of NCAM reveal that in spite of relatively normal morphology and ultrastructure, the presynaptic terminals have profound alterations in the mechanisms of recycling of synaptic vesicles. These alterations, including the appearan...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(01)00527-x
更新日期:2001-12-06 00:00:00
abstract::Cortical synaptic circuitry develops rapidly in the second postnatal week, simultaneous with experience-dependent turnover of dendritic spines. To relate the emergence of sensory maps to synaptogenesis, we recorded synaptic potentials evoked by whisker deflection in layer 2/3 neurons from postnatal day (P) 12 to 20. A...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00360-9
更新日期:2001-08-02 00:00:00
abstract::Promises are one of the oldest human-specific psychological mechanisms fostering cooperation and trust. Here, we study the neural underpinnings of promise keeping and promise breaking. Subjects first make a promise decision (promise stage), then they anticipate whether the promise affects the interaction partner's dec...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.11.017
更新日期:2009-12-10 00:00:00
abstract::It is widely believed that the brain performs approximate probabilistic inference to estimate causal variables in the world from ambiguous sensory data. To understand these computations, we need to analyze how information is represented and transformed by the actions of nonlinear recurrent neural networks. We propose ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.05.028
更新日期:2017-06-07 00:00:00
abstract::Forming long-term memory (LTM) often requires repetitive experience spread over time. Studies in Drosophila suggest aversive olfactory LTM is optimal after spaced training, multiple trials of differential odor conditioning with rest intervals. Memory after spaced training is frequently compared to that after the same ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.03.013
更新日期:2020-06-17 00:00:00
abstract::Bcl-2 is a major regulator of programmed cell death, a critical process in shaping the developing nervous system. To assess whether Bcl-2 is involved in regulating neuronal survival and in mediating the neuroprotective action of neurotrophic factors, we generated Bcl-2-deficient mice. At birth, the number of facial mo...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80282-2
更新日期:1996-07-01 00:00:00
abstract::The auditory cortex encodes information about sounds through the combined activity of large numbers of neurons, but the way this population activity is organized has not been clear. In this issue of Neuron, Bathellier et al. (2012) show that firing in the superficial layers of auditory cortex is organized into a small...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2012.10.007
更新日期:2012-10-18 00:00:00
abstract::Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excito...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/s0896-6273(02)00631-1
更新日期:2002-03-14 00:00:00
abstract::Depending on the arousal state, neuronal networks display discrete activity patterns that profoundly affect information processing in the brain. In this issue of Neuron, Kurotani et al. report bidirectional modification of inhibition by oscillatory patterns in the neocortex; a mechanism likely to control the impact of...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2008.03.010
更新日期:2008-03-27 00:00:00
abstract::Binocular vision relies upon the existence of contralateral and ispilateral projections from retinal ganglion cells. Contacts between visual axons and optic chiasm cells are critical for the sorting of crossed and uncrossed projections during development. In this issue of Neuron, a study by Williams et al. shows that ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2006.05.002
更新日期:2006-05-18 00:00:00
abstract::Astrocytes release glutamate, which can modulate nearby synapses, but how this release is accomplished remains debated. In this issue of Neuron, Yang et al. (2019) show that the volume-regulated anion channel Swell1 in astrocytes mediates the release of glutamate and impacts synaptic transmission, learning and memory,...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.05.005
更新日期:2019-05-22 00:00:00
abstract::In this issue of Neuron, Ambrozkiewicz et al. (2018) define a new molecular circuit controlling neuronal polarization and migration through the transcription factor SOX9 to coordinate the production of regulators of both protein synthesis and degradation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.11.022
更新日期:2018-12-05 00:00:00
abstract::Injured peripheral neurons successfully activate a proregenerative transcriptional program to enable axon regeneration and functional recovery. How transcriptional regulators coordinate the expression of such program remains unclear. Here we show that hypoxia-inducible factor 1α (HIF-1α) controls multiple injury-induc...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.09.050
更新日期:2015-11-18 00:00:00
abstract::Trk tyrosine kinases are receptors for members of the neurotrophin family and are crucial for growth and survival of specific populations of neurons. Yet, the functions of neurotrophin-Trk signaling in postnatal development as well as maintenance and plasticity of the adult nervous system are less clear. We report her...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.03.009
更新日期:2005-04-07 00:00:00
abstract::To investigate the role of the pathogenic prion protein (PrP(Sc)) in controlling susceptibility to foreign prions, two Syrian hamster (SHa) prion strains, Sc237 and DY, were transmitted to transgenic mice expressing chimeric SHa/mouse PrP genes, Tg(MH2M). First passage of SHa(Sc237) prions exhibited prolonged incubati...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00726-2
更新日期:2002-06-13 00:00:00
abstract::Type IIA rat brain Na+ channel alpha subunits were expressed in CHO cells by nuclear microinjection or by transfection using a vector containing both metallothionein and bacteriophage SP6 promoters. Stable cell lines expressing Na+ channels were isolated, and whole-cell Na+ currents of 0.9-14 nA were recorded. The mea...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90108-p
更新日期:1992-01-01 00:00:00
abstract::Traditional studies of neuroanatomical connections require injection of tracer compounds into living brains, then histology of the postmortem tissue. Here, we describe and validate a compound that reveals neuronal connections in vivo, using MRI. The classic anatomical tracer CTB (cholera-toxin subunit-B) was conjugate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.03.010
更新日期:2011-04-28 00:00:00
abstract::Commissural axons are attracted to the midline intermediate target by chemoattractants, but upon crossing the midline they switch off responsiveness to attractants and switch on responsiveness to midline repellents, which expel the axons from the midline and enable them to move on. Here we show that midline exit also ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.01.006
更新日期:2008-02-28 00:00:00