The neural circuitry of a broken promise.

abstract：:In the mammalian olfactory bulb, signal processing is mediated by synaptic interactions between dendrites. Glutamate released from mitral cell dendrites excites dendritic spines of granule cells, which in turn release GABA back onto the mitral cell dendrites, forming a reciprocal synaptic pair. This feedback synaptic ...

journal_title：Neuron

authors： Chen WR,Xiong W,Shepherd GM

更新日期：2000-03-01 00:00:00

abstract：:Brain functions are based on the dynamic interaction of excitatory and inhibitory inputs. Spillover of glutamate from excitatory synapses may diffuse to and modulate nearby inhibitory synapses. By recording unitary inhibitory postsynaptic currents (uIPSCs) from cell pairs in CA1 of the hippocampus, we demonstrated tha...

journal_title：Neuron

authors： Jiang L,Xu J,Nedergaard M,Kang J

更新日期：2001-05-01 00:00:00

abstract：:The brain is a vulnerable metabolic organ and must adapt to different fuel conditions to sustain function. Nerve terminals are a locus of this vulnerability, but how they regulate ATP synthesis as fuel conditions vary is unknown. We show that synapses can switch from glycolytic to oxidative metabolism, but to do so, t...

journal_title：Neuron

authors： Ashrafi G,de Juan-Sanz J,Farrell RJ,Ryan TA

更新日期：2020-02-19 00:00:00

abstract：:Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative disorder Huntington's disease (HD). The gene encoding huntingtin, HTT, and its dominantly inherited mutation were identified more than 20 years ago...

journal_title：Neuron

authors： Saudou F,Humbert S

更新日期：2016-03-02 00:00:00

abstract：:Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to an increase of clathrin-coated intermediates and of polymerized actin at endocytic zones of nerve terminals. These changes correlate with elevated levels of PI(4,5)P(2) in neurons. We report that phosphatidylinositol ph...

journal_title：Neuron

authors： Wenk MR,Pellegrini L,Klenchin VA,Di Paolo G,Chang S,Daniell L,Arioka M,Martin TF,De Camilli P

更新日期：2001-10-11 00:00:00

abstract：:Innate defense behaviors (IDBs) evoked by threatening sensory stimuli are essential for animal survival. Although subcortical circuits are implicated in IDBs, it remains largely unclear whether sensory cortex modulates IDBs and what the underlying neural pathways are. Here, we show that optogenetic silencing of cortic...

journal_title：Neuron

authors： Liang F,Xiong XR,Zingg B,Ji XY,Zhang LI,Tao HW

更新日期：2015-05-06 00:00:00

abstract：:There has been a surge of interest in how inhibitory neurons influence the output of local circuits in the brain. In this issue of Neuron, Scholl et al. (2015) provide a compelling argument for what one class of inhibitory neurons actually does. ...

journal_title：Neuron

authors： Trachtenberg JT

更新日期：2015-07-15 00:00:00

abstract：:Evolutionary conservation of members of the NGF family in vertebrates was studied by DNA sequence analysis of PCR fragments for NGF, BDNF, and NT-3 from human, rat, chicken, viper, Xenopus, salmon, and ray. The results showed that the three factors are highly conserved from fishes to mammals. Phylogenetic trees reflec...

journal_title：Neuron

authors： Hallböök F,Ibáñez CF,Persson H

更新日期：1991-05-01 00:00:00

abstract：:Prime diagnostic criteria for drug addiction include uncontrollable urges to obtain drugs and reduced behavioral responding for natural rewards. Cellular adaptations in the glutamate projection from the prefrontal cortex (PFC) to the nucleus accumbens have been discovered in rats withdrawn from cocaine that may underl...

journal_title：Neuron

authors： Kalivas PW,Volkow N,Seamans J

更新日期：2005-03-03 00:00:00

abstract：:Short-term augmentation of synaptic transmission at sensory neuron synapses of Aplysia contributes to behavioral sensitization and is one of the current models for a cellular mechanism of learning. This neuromodulatory process, mediated at least in part by the facilitatory neurotransmitter serotonin (5-HT) acting thro...

journal_title：Neuron

authors： Klein M

更新日期：1994-07-01 00:00:00

abstract：:RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...

journal_title：Neuron

authors： Nussbacher JK,Tabet R,Yeo GW,Lagier-Tourenne C

更新日期：2019-04-17 00:00:00

abstract：:It has been postulated that selective temporal coordination between neurons and development of functional neuronal assemblies are fundamental for brain function and behavior. Still, there is little evidence that functionally relevant coordination emerges preferentially in neuronal assemblies directly controlling behav...

journal_title：Neuron

authors： Koralek AC,Costa RM,Carmena JM

更新日期：2013-09-04 00:00:00

abstract：:Mammals are able to navigate to hidden goal locations by direct routes that may traverse previously unvisited terrain. Empirical evidence suggests that this "vector navigation" relies on an internal representation of space provided by the hippocampal formation. The periodic spatial firing patterns of grid cells in the...

journal_title：Neuron

authors： Bush D,Barry C,Manson D,Burgess N

更新日期：2015-08-05 00:00:00

abstract：:Brain areas in the frontal lobe have been implicated in behavioral flexibility and control. The study by Johnston et al. in this issue of Neuron provides novel insights into the roles of the prefrontal and anterior cingulate cortices in controlling behavior. ...

journal_title：Neuron

authors： Rainer G

更新日期：2007-02-01 00:00:00

abstract：:Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...

journal_title：Neuron

authors： Niethammer M,Smith DS,Ayala R,Peng J,Ko J,Lee MS,Morabito M,Tsai LH

更新日期：2000-12-01 00:00:00

abstract：:Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter mi...

journal_title：Neuron

authors： Renthal W,Kumar A,Xiao G,Wilkinson M,Covington HE 3rd,Maze I,Sikder D,Robison AJ,LaPlant Q,Dietz DM,Russo SJ,Vialou V,Chakravarty S,Kodadek TJ,Stack A,Kabbaj M,Nestler EJ

更新日期：2009-05-14 00:00:00

abstract：:Commissural axons are attracted to the midline intermediate target by chemoattractants, but upon crossing the midline they switch off responsiveness to attractants and switch on responsiveness to midline repellents, which expel the axons from the midline and enable them to move on. Here we show that midline exit also ...

journal_title：Neuron

authors： Gore BB,Wong KG,Tessier-Lavigne M

更新日期：2008-02-28 00:00:00

abstract：:Neurodegenerative diseases have been intensively studied, but a comprehensive understanding of their pathogenesis remains elusive. An increasing body of evidence suggests that non-cell-autonomous processes play critical roles during the initiation and spatiotemporal progression or propagation of the dominant pathology...

journal_title：Neuron

authors： Garden GA,La Spada AR

更新日期：2012-03-08 00:00:00

abstract：:Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion i...

journal_title：Neuron

authors： Orr HT

更新日期：2011-10-20 00:00:00

abstract：:How does the noradrenergic nucleus locus coeruleus act on target networks to regulate behavior? In this issue of Neuron, Zerbi et al. (2019) combine functional neuroimaging and pharmacogenetics in mice to tackle that question, uncovering a network action underlying stress. And providing insight for cognition? ...

journal_title：Neuron

authors： Bouret S

更新日期：2019-08-21 00:00:00

abstract：:A critical feature of neural networks is that they balance excitation and inhibition to prevent pathological dysfunction. How this is achieved is largely unknown, although deficits in the balance contribute to many neurological disorders. We show here that a microRNA (miR-101) is a key orchestrator of this essential f...

journal_title：Neuron

authors： Lippi G,Fernandes CC,Ewell LA,John D,Romoli B,Curia G,Taylor SR,Frady EP,Jensen AB,Liu JC,Chaabane MM,Belal C,Nathanson JL,Zoli M,Leutgeb JK,Biagini G,Yeo GW,Berg DK

更新日期：2016-12-21 00:00:00

abstract：:Following alpha-latrotoxin application to cerebellar slices, bursts of miniature IPSCs (mIPSCs) were observed in interneurons of the molecular layer. Within bursts, mIPSCs had homogeneous amplitudes with a narrow Gaussian distribution. Analysis of successive event amplitudes revealed an interaction between consecutive...

journal_title：Neuron

authors： Auger C,Marty A

更新日期：1997-07-01 00:00:00

abstract：:Mutations in the retinal degeneration, retinal degeneration slow(/peripherin) and rhodopsin genes cause photoreceptor degeneration in humans and mice. Although the phenotypes arising from these mutations are different, suggesting different mechanisms of pathogenesis, we present evidence that apoptosis may be the final...

journal_title：Neuron

authors： Chang GQ,Hao Y,Wong F

更新日期：1993-10-01 00:00:00

abstract：:Local axon degeneration is a common pathological feature of many neurodegenerative diseases and peripheral neuropathies. While it is believed to operate with an apoptosis-independent molecular program, the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons,...

journal_title：Neuron

authors： Zhai Q,Wang J,Kim A,Liu Q,Watts R,Hoopfer E,Mitchison T,Luo L,He Z

更新日期：2003-07-17 00:00:00

abstract：:In this issue of Neuron, Espuny-Camacho et al. (2017) generate a humanized Alzheimer's disease (AD) model that reveals species-specific vulnerability of human neurons to AD pathology. This model provides key insights for disease mechanism and therapeutic discovery for AD. ...

journal_title：Neuron

authors： Cahill MK,Huang EJ

更新日期：2017-03-08 00:00:00

abstract：:Persistent neural activity that outlasts an initial stimulus is thought to provide a mechanism for the transient storage of memory. In this issue of Neuron, Fransén et al. identify important principles for a cell-autonomous mechanism of graded persistent firing using an elegant combination of experimental and computat...

journal_title：Neuron

authors： Dudman JT,Siegelbaum SA

更新日期：2006-03-02 00:00:00

abstract：:Does our understanding of the human brain remain incomplete without a proper understanding of how the brain processes music? Here, the author makes a passionate plea for the use of music in the investigation of human emotion and its brain correlates, arguing that music can change activity in all brain structures assoc...

journal_title：Neuron

authors： Koelsch S

更新日期：2018-06-27 00:00:00

abstract：:Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic ...

journal_title：Neuron

authors： Frank CA,Kennedy MJ,Goold CP,Marek KW,Davis GW

更新日期：2006-11-22 00:00:00

abstract：:The visual cortex represents stimuli through the activity of neuronal populations. We measured the evolution of this activity in space and time by imaging voltage-sensitive dyes in cat area V1. Contrast-reversing stimuli elicit responses that oscillate at twice the stimulus frequency, indicating that signals originate...

journal_title：Neuron

authors： Benucci A,Frazor RA,Carandini M

更新日期：2007-07-05 00:00:00

abstract：:Accurate perception of the actions and intentions of other people is essential for successful interactions in a social environment. Several cortical areas that support this process respond selectively in fMRI to static and dynamic displays of human bodies and faces. Here we apply pattern-analysis techniques to arrive ...

journal_title：Neuron

authors： Peelen MV,Wiggett AJ,Downing PE

更新日期：2006-03-16 00:00:00