Abstract:
:Evolutionary conservation of members of the NGF family in vertebrates was studied by DNA sequence analysis of PCR fragments for NGF, BDNF, and NT-3 from human, rat, chicken, viper, Xenopus, salmon, and ray. The results showed that the three factors are highly conserved from fishes to mammals. Phylogenetic trees reflecting the evolution and speciation of the members of the NGF family were constructed. In addition, the gene for a fourth member of the family, neurotrophin-4 (NT-4), was isolated from Xenopus and viper. The NT-4 gene encodes a precursor protein of 236 amino acids, which is processed into a 123 amino acid mature NT-4 protein with 50%-60% amino acid identity to NGF, BDNF, and NT-3. The NT-4 protein was shown to interact with the low affinity NGF receptor and elicited neurite outgrowth from explanted dorsal root ganglia with no and lower activity in sympathetic and nodose ganglia, respectively. Northern blot analysis of different tissues from Xenopus showed NT-4 mRNA only in ovary, where it was present at levels over 100-fold higher than those of NGF mRNA in heart.
journal_name
Neuronjournal_title
Neuronauthors
Hallböök F,Ibáñez CF,Persson Hdoi
10.1016/0896-6273(91)90180-8subject
Has Abstractpub_date
1991-05-01 00:00:00pages
845-58issue
5eissn
0896-6273issn
1097-4199pii
0896-6273(91)90180-8journal_volume
6pub_type
杂志文章相关文献
NEURON文献大全abstract::Several subunits of the glutamate receptor of the AMPA subtype have been cloned recently. These subunits, named GluR1, GluR2, GluR3, and GluR4, exist as two splicing variants (flip and flop). We have determined the subset of AMPA receptor subunits expressed by single cerebellar Purkinje cells in culture. This was achi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90164-9
更新日期:1992-08-01 00:00:00
abstract::Statistical regularities in the environment create prior beliefs that we rely on to optimize our behavior when sensory information is uncertain. Bayesian theory formalizes how prior beliefs can be leveraged and has had a major impact on models of perception, sensorimotor function, and cognition. However, it is not kno...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.06.012
更新日期:2019-09-04 00:00:00
abstract::Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders, but its role in normal neuronal function is largely unknown. Here we show that GSK3beta mediates an interaction between two major forms of synaptic plasticity in the brain, N-methyl-D-aspartate (NMDA) receptor-dependent long-term po...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.01.029
更新日期:2007-03-01 00:00:00
abstract::The brain mechanisms underlying visual object categorization remain unclear. In this issue of Neuron, Minamimoto and colleagues introduce a novel task that associates each category with a different incentive value, and they demonstrate that it can be learned within a single session even after ablation of the lateral p...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2010.05.012
更新日期:2010-05-27 00:00:00
abstract::To investigate the role of intracellular Ca2+ in the survival of developing neurons before they become neurotrophic factor dependent, we have studied chick embryo nodose neurons, which have a particularly protracted period of neuorophic factor independence. Pharmacological reduction of intracellular free Ca2+ or deple...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90193-h
更新日期:1992-09-01 00:00:00
abstract::We used fear conditioning, which is known to alter synaptic efficacy in lateral amygdala (LA), to study molecular mechanisms underlying long-term memory. Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated with GRB2 in LA significantly more in conditioned than in control rat...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)01047-4
更新日期:2002-11-14 00:00:00
abstract::Olfactory receptor neurons (ORNs) transform scant chemical inputs into significant neural signals. This transformation requires signal amplification. In this issue of Neuron, Ng et al. (2019) identified a mechanism by which the signals evoked by pheromones are amplified in the ORNs that selectively promote courtship b...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.11.021
更新日期:2019-12-04 00:00:00
abstract::A neural network can sustain and switch between different activity patterns to execute multiple behaviors. By monitoring the decision making for directional locomotion through motor circuit calcium imaging in behaving Caenorhabditis elegans (C. elegans), we reveal that C. elegans determines the directionality of movem...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.09.005
更新日期:2011-11-17 00:00:00
abstract::We have examined the role of presynaptic residual calcium in maintaining long-term changes in synaptic efficacy observed at mossy fiber synapses between hippocampal dentate granule cells and CA3 pyramidal cells. Calcium concentrations in individual mossy fiber terminals in hippocampal slice were optically measured wit...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90297-d
更新日期:1991-09-01 00:00:00
abstract::beta-Adrenergic receptor activation has a central role in the enhancement of memory formation that occurs during heightened states of emotional arousal. Although beta-adrenergic receptor activation may enhance memory formation by modulating long-term potentiation (LTP), a candidate synaptic mechanism involved in memor...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80179-8
更新日期:1996-09-01 00:00:00
abstract::Our tactile perception of external objects depends on skin-object interactions. The mechanics of contact dictates the existence of fundamental spatiotemporal input features-contact initiation and cessation, slip, and rolling contact-that originate from the fact that solid objects do not interpenetrate. However, it is ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.07.038
更新日期:2014-09-17 00:00:00
abstract::To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00682-2
更新日期:2003-10-30 00:00:00
abstract::How a single fertilized cell generates diverse neuronal populations has been a fundamental biological problem since the 19(th) century. Classical histological methods revealed that postmitotic neurons are produced in a precise temporal and spatial order from germinal cells lining the cerebral ventricles. In the 20(th)...
journal_title:Neuron
pub_type: 历史文章,杂志文章
doi:10.1016/j.neuron.2011.05.005
更新日期:2011-05-26 00:00:00
abstract::Immunophilins, including FK506-binding proteins (FKBPs), are protein chaperones with peptidyl-prolyl isomerase (PPIase) activity. Initially identified as pharmacological receptors for immunosuppressants to regulate immune responses via isomerase-independent mechanisms, FKBPs are most highly expressed in the nervous sy...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.09.025
更新日期:2009-11-25 00:00:00
abstract::We have made little recent progress developing effective new treatments for neuropsychiatric and neurodevelopmental disorders. Novel molecular mechanisms have been identified, but have not translated into the clinic. We suggest an alternative: combinations of treatments targeting different aspects of final common path...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.10.006
更新日期:2014-11-05 00:00:00
abstract::The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor is important for synaptic plasticity and nervous system development and function. We have used genetic and electrophysiological methods to demonstrate that NMR-1, a Caenorhabditis elegans NMDA-type ionotropic glutamate receptor subunit, plays a role in the ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00394-4
更新日期:2001-08-30 00:00:00
abstract::In mammals, the osmolality of the extracellular fluid (ECF) is highly stable despite radical changes in salt/water intake and excretion. Afferent systems are required to detect hypo- or hyperosmotic shifts in the ECF to trigger homeostatic control of osmolality. In humans, a pressor reflex is triggered by simply drink...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.12.028
更新日期:2011-01-27 00:00:00
abstract::How do neurons develop, control, and maintain their electrical signaling properties in spite of ongoing protein turnover and perturbations to activity? From generic assumptions about the molecular biology underlying channel expression, we derive a simple model and show how it encodes an "activity set point" in single ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.04.002
更新日期:2014-05-21 00:00:00
abstract::We investigated the contribution of the inferior temporal (IT) cortical neurons to the active maintenance of internal representations. The activity of single neurons in the IT cortex was recorded while the monkeys performed a sequential-type associative memory task in which distractor stimuli interrupted the delay epo...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.09.028
更新日期:2005-12-08 00:00:00
abstract::In the developing mammalian visual system, retinal fibers grow through the optic chiasm, where one population crosses to the opposite side of the brain and the other does not. Evidence from labeling growing retinal axons with the carbocyanine dye Dil in mouse embryos indicates that the two subpopulations diverge at a ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90307-2
更新日期:1990-08-01 00:00:00
abstract::Homeostatic mechanisms stabilize neuronal activity in vivo, but whether this process gives rise to balanced network dynamics is unknown. Here, we continuously monitored the statistics of network spiking in visual cortical circuits in freely behaving rats for 9 days. Under control conditions in light and dark, networks...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.08.031
更新日期:2019-11-20 00:00:00
abstract::Currents mediated by a glutamate transporter cloned from human motor cortex were measured in Xenopus oocytes. In the absence of glutamate, voltage jumps induced Na(+)-dependent capacitive currents that were blocked by kainate, a competitive transport antagonist. The pre-steady-state currents can be described by an ord...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90340-2
更新日期:1995-05-01 00:00:00
abstract::Memory distortions and illusions have been thoroughly documented in psychological studies, but little is known about the neuroanatomical correlates of true and false memories. Vivid but illusory memories can be induced by asking people whether they recall or recognize words that were not previously presented, but are ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80158-0
更新日期:1996-08-01 00:00:00
abstract::Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.03.025
更新日期:2011-06-09 00:00:00
abstract::Measuring electrical activity in large numbers of cells with high spatial and temporal resolution is a fundamental problem for the study of neural development and information processing. To address this problem, we have constructed a novel, genetically encoded probe that can be used to measure transmembrane voltage in...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80955-1
更新日期:1997-10-01 00:00:00
abstract::Axon pruning by degeneration remodels exuberant axonal connections and is widely required for the development of proper circuitry in the nervous system from insects to mammals. Developmental axon degeneration morphologically resembles injury-induced Wallerian degeneration, suggesting similar underlying mechanisms. As ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.05.013
更新日期:2006-06-15 00:00:00
abstract::The intraparietal cortex is involved in the control of visually guided actions, like reach-to-grasp movements, which require extracting the 3D shape and position of objects from 2D retinal images. Using fMRI in behaving monkeys, we investigated the role of the intraparietal cortex in processing stereoscopic informatio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.06.040
更新日期:2007-08-02 00:00:00
abstract::We present evidence that synapse retraction occurs during normal synaptic growth at the Drosophila neuromuscular junction (NMJ). An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex. Arp-1 dsRNA enhances synapse retrac...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00721-3
更新日期:2002-05-30 00:00:00
abstract::The sympathetic innervation of rat sweat glands undergoes a target-induced switch from a noradrenergic to a cholinergic and peptidergic phenotype during development. Treatment of cultured sympathetic neurons with sweat gland extracts mimics many of the changes seen in vivo. Extracts induce choline acetyltransferase ac...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90350-o
更新日期:1990-12-01 00:00:00
abstract::Neurodegenerative diseases have been intensively studied, but a comprehensive understanding of their pathogenesis remains elusive. An increasing body of evidence suggests that non-cell-autonomous processes play critical roles during the initiation and spatiotemporal progression or propagation of the dominant pathology...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2012.02.017
更新日期:2012-03-08 00:00:00