Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice.

Abstract:

:Mutations in the retinal degeneration, retinal degeneration slow(/peripherin) and rhodopsin genes cause photoreceptor degeneration in humans and mice. Although the phenotypes arising from these mutations are different, suggesting different mechanisms of pathogenesis, we present evidence that apoptosis may be the final common pathway of the disease process linking genotype to phenotype. We observed internucleosomal cleavage of retinal DNA by gel electrophoresis and fragmented DNA at the single cell level by labeling the nicked DNA ends with biotinylated poly(dU). In retinal degeneration mice, DNA fragmentation occurred during the period of photoreceptor degeneration. In retinal degeneration slow mice and in transgenic mice expressing a mutant (Pro347Ser) rhodopsin gene, DNA fragmentation occurred after normal histogenetic cell death (also apoptosis) had ceased. Since DNA fragmentation by internucleosomal cleavage is a cardinal feature of apoptosis, our data suggest that all three of these genetic mutations lead to apoptosis.

journal_name

Neuron

journal_title

Neuron

authors

Chang GQ,Hao Y,Wong F

doi

10.1016/0896-6273(93)90072-y

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

595-605

issue

4

eissn

0896-6273

issn

1097-4199

pii

0896-6273(93)90072-Y

journal_volume

11

pub_type

杂志文章

相关文献

NEURON文献大全
  • Hidden Figures: A Non-translated RNA Regulates Axonal Neurotrophin Signaling.

    abstract::In this issue of Neuron, Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3' UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2019.04.019

    authors: Panayotis N,Fainzilber M

    更新日期:2019-05-08 00:00:00

  • Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.

    abstract::We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR5(2b,) GluR5(2c), and GluR6. Of these, we show that both GRIP and PICK1 interactions are required to maintain KAR-mediated synaptic function at mossy fiber-CA3 synapses. In a...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(02)01191-1

    authors: Hirbec H,Francis JC,Lauri SE,Braithwaite SP,Coussen F,Mulle C,Dev KK,Coutinho V,Meyer G,Isaac JT,Collingridge GL,Henley JM

    更新日期:2003-02-20 00:00:00

  • Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo.

    abstract::Dopamine neurons in the ventral tegmental area (VTA) play an important role in the motivational systems underlying drug addiction, and recent work has suggested that they also release the excitatory neurotransmitter glutamate. To assess a physiological role for glutamate corelease, we disrupted the expression of vesic...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2010.02.012

    authors: Hnasko TS,Chuhma N,Zhang H,Goh GY,Sulzer D,Palmiter RD,Rayport S,Edwards RH

    更新日期:2010-03-11 00:00:00

  • The Biology of Huntingtin.

    abstract::Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative disorder Huntington's disease (HD). The gene encoding huntingtin, HTT, and its dominantly inherited mutation were identified more than 20 years ago...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2016.02.003

    authors: Saudou F,Humbert S

    更新日期:2016-03-02 00:00:00

  • Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

    abstract::Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental question in addiction biology is why exogenous opiate drugs have a high liability for inducing tolerance and addiction while native ligands do not. Studies indicate that highly addictive opiate d...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(01)80032-5

    authors: Whistler JL,Chuang HH,Chu P,Jan LY,von Zastrow M

    更新日期:1999-08-01 00:00:00

  • Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).

    abstract::GABA(B) (gamma-aminobutyric acid type B) receptors are important for keeping neuronal excitability under control. Cloned GABA(B) receptors do not show the expected pharmacological diversity of native receptors and it is unknown whether they contribute to pre- as well as postsynaptic functions. Here, we demonstrate tha...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(01)00345-2

    authors: Schuler V,Lüscher C,Blanchet C,Klix N,Sansig G,Klebs K,Schmutz M,Heid J,Gentry C,Urban L,Fox A,Spooren W,Jaton AL,Vigouret J,Pozza M,Kelly PH,Mosbacher J,Froestl W,Käslin E,Korn R,Bischoff S,Kaupmann K,van der

    更新日期:2001-07-19 00:00:00

  • Neurocognitive phenotypes and genetic dissection of disorders of brain and behavior.

    abstract::Elucidating the molecular mechanisms underlying quantitative neurocognitive phenotypes will further our understanding of the brain's structural and functional architecture and advance the diagnosis and treatment of the psychiatric disorders that these traits underlie. Although many neurocognitive traits are highly her...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2010.10.007

    authors: Congdon E,Poldrack RA,Freimer NB

    更新日期:2010-10-21 00:00:00

  • AMPA receptor subunits expressed by single Purkinje cells.

    abstract::Several subunits of the glutamate receptor of the AMPA subtype have been cloned recently. These subunits, named GluR1, GluR2, GluR3, and GluR4, exist as two splicing variants (flip and flop). We have determined the subset of AMPA receptor subunits expressed by single cerebellar Purkinje cells in culture. This was achi...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(92)90164-9

    authors: Lambolez B,Audinat E,Bochet P,Crépel F,Rossier J

    更新日期:1992-08-01 00:00:00

  • Video game for monkeys.

    abstract::Recent progress in neurophysiological recording has developed in two directions. One relies on multimicroelectrodes to study correlations in neuron firing. The other relies on sophisticated tasks to distinguish successive stages of neuronal processing. In this issue of Neuron, Shichinohe et al. take this second approa...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2009.05.018

    authors: Schlag JD,Schlag-Rey M

    更新日期:2009-06-11 00:00:00

  • A chemical-genetic approach to studying neurotrophin signaling.

    abstract::Trk tyrosine kinases are receptors for members of the neurotrophin family and are crucial for growth and survival of specific populations of neurons. Yet, the functions of neurotrophin-Trk signaling in postnatal development as well as maintenance and plasticity of the adult nervous system are less clear. We report her...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.03.009

    authors: Chen X,Ye H,Kuruvilla R,Ramanan N,Scangos KW,Zhang C,Johnson NM,England PM,Shokat KM,Ginty DD

    更新日期:2005-04-07 00:00:00

  • Robust microcircuit synchronization by inhibitory connections.

    abstract::Microcircuits in different brain areas share similar architectural and biophysical properties with compact motor networks known as central pattern generators (CPGs). Consequently, CPGs have been suggested as valuable biological models for understanding of microcircuit dynamics and particularly, their synchronization. ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.12.032

    authors: Szücs A,Huerta R,Rabinovich MI,Selverston AI

    更新日期:2009-02-12 00:00:00

  • Altering cortical connectivity: remediation-induced changes in the white matter of poor readers.

    abstract::Neuroimaging studies using diffusion tensor imaging (DTI) have revealed regions of cerebral white matter with decreased microstructural organization (lowerfractional anisotropy or FA) among poor readers. We examined whether 100 hr of intensive remedial instruction affected the white matter of 8- to 10-year-old poor re...

    journal_title:Neuron

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.neuron.2009.10.018

    authors: Keller TA,Just MA

    更新日期:2009-12-10 00:00:00

  • MCH Neurons Regulate Permeability of the Median Eminence Barrier.

    abstract::Melanin-concentrating hormone (MCH)-expressing neurons are key regulators of energy and glucose homeostasis. Here, we demonstrate that they provide dense projections to the median eminence (ME) in close proximity to tanycytes and fenestrated vessels. Chemogenetic activation of MCH neurons as well as optogenetic stimul...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2020.04.020

    authors: Jiang H,Gallet S,Klemm P,Scholl P,Folz-Donahue K,Altmüller J,Alber J,Heilinger C,Kukat C,Loyens A,Müller-Fielitz H,Sundaram S,Schwaninger M,Prevot V,Brüning JC

    更新日期:2020-07-22 00:00:00

  • A p75(NTR) pivoting paradigm propels perspicacity.

    abstract::The p75 neurotrophin receptor (p75(NTR)) is involved in numerous neuronal signaling paths but its fundamental signaling mechanisms are unknown. In this issue of Neuron, Vilar et al. show that p75NTR functions as a covalently crosslinked dimer to transduce NGF-induced signaling events. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2009.04.005

    authors: Barker PA

    更新日期:2009-04-16 00:00:00

  • NCAM 180 acting via a conserved C-terminal domain and MLCK is essential for effective transmission with repetitive stimulation.

    abstract::NCAM 180 isoform null neuromuscular junctions are unable to effectively mobilize and exocytose synaptic vesicles and thus exhibit periods of total transmission failure during high-frequency repetitive stimulation. We have identified a highly conserved C-terminal (KENESKA) domain on NCAM that is required to maintain ef...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.05.018

    authors: Polo-Parada L,Plattner F,Bose C,Landmesser LT

    更新日期:2005-06-16 00:00:00

  • Hooked on the D3 receptor: CaMKII's new addiction.

    abstract::The dopaminergic D3 receptor (D3R) is emerging as an antagonist of sensitized behavior induced by addictive drugs such as cocaine. New work by Wang and coworkers in this issue of Neuron now identifies CaMKII as an important negative regulator of the D3R. CaMKII relieves the D3R-mediated inhibition on sensitized behavi...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2009.01.025

    authors: Hell JW

    更新日期:2009-02-12 00:00:00

  • TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons.

    abstract::The vertebrate ventral midbrain contains 3-4 x 10(4) dopaminergic neurons that influence motor activity, emotional behavior, and cognition. Recently, glial cell line-derived neurotrophic factor (GDNF) was shown to be a potent survival factor for these dopaminergic neurons in culture. However, many midbrain dopaminergi...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(94)90062-0

    authors: Poulsen KT,Armanini MP,Klein RD,Hynes MA,Phillips HS,Rosenthal A

    更新日期:1994-11-01 00:00:00

  • Pten-less dentate granule cells make fits.

    abstract::Hippocampal dentate granule cell abnormalities are thought to play a causative role in temporal lobe epilepsy, but their precise contribution has not been dissociated from coexisting pathological changes. In this issue of Neuron, Pun et al. (2012) show, for the first time, that inducing proexcitatory changes in a subs...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2012.09.008

    authors: Althaus AL,Parent JM

    更新日期:2012-09-20 00:00:00

  • Feedforward to the past: the relation between neuronal connectivity, amplification, and short-term memory.

    abstract::Two studies in this issue of Neuron challenge widely held assumptions about the role of positive feedback in recurrent neuronal networks. Goldman shows that such feedback is not necessary for memory maintenance in a neural integrator, and Murphy and Miller show that it is not necessary for amplification of orientation...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2009.02.006

    authors: Ganguli S,Latham P

    更新日期:2009-02-26 00:00:00

  • Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments.

    abstract::Both the sec6/8 complex and septin filaments have been implicated in directing vesicles and proteins to sites of active membrane addition in yeast. The rat brain sec6/8 complex coimmunoprecipitates with a filament composed of four mammalian septins, suggesting an interaction between these complexes. One of the septins...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80493-6

    authors: Hsu SC,Hazuka CD,Roth R,Foletti DL,Heuser J,Scheller RH

    更新日期:1998-06-01 00:00:00

  • Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3.

    abstract::The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of b...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(03)00368-4

    authors: Meng Y,Zhang Y,Jia Z

    更新日期:2003-07-03 00:00:00

  • Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex.

    abstract::I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybd...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(03)00570-1

    authors: Chen H,Kim LA,Rajan S,Xu S,Goldstein SA

    更新日期:2003-09-25 00:00:00

  • Formal learning theory dissociates brain regions with different temporal integration.

    abstract::Learning can be characterized as the extraction of reliable predictions about stimulus occurrences from past experience. In two experiments, we investigated the interval of temporal integration of previous learning trials in different brain regions using implicit and explicit Pavlovian fear conditioning with a dynamic...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.06.008

    authors: Gläscher J,Büchel C

    更新日期:2005-07-21 00:00:00

  • Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors.

    abstract::Subiculum, the primary efferent pathway of hippocampus, participates in memory for spatial tasks, relapse to drug abuse, and temporal lobe seizures. Subicular pyramidal neurons exhibit low-threshold burst firing driven by a spike afterdepolarization. Here we report that burst firing can be regulated by stimulation of ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.12.013

    authors: Moore SJ,Cooper DC,Spruston N

    更新日期:2009-01-29 00:00:00

  • AMPA receptor tetramerization is mediated by Q/R editing.

    abstract::AMPA-type glutamate receptors (AMPARs) play a major role in excitatory synaptic transmission and plasticity. Channel properties are largely dictated by their composition of the four subunits, GluR1-4 (or A-D). Here we show that AMPAR assembly and subunit stoichiometry are determined by RNA editing in the pore loop. We...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(03)00668-8

    authors: Greger IH,Khatri L,Kong X,Ziff EB

    更新日期:2003-11-13 00:00:00

  • Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.

    abstract::In neurons, posttranslational modification by palmitate regulates the trafficking and function of signaling molecules, neurotransmitter receptors, and associated synaptic scaffolding proteins. However, the enzymatic machinery involved in protein palmitoylation has remained elusive. Here, using biochemical assays, we s...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2004.11.027

    authors: Huang K,Yanai A,Kang R,Arstikaitis P,Singaraja RR,Metzler M,Mullard A,Haigh B,Gauthier-Campbell C,Gutekunst CA,Hayden MR,El-Husseini A

    更新日期:2004-12-16 00:00:00

  • Synchronization of olfactory bulb mitral cells by precisely timed inhibitory inputs.

    abstract::Synchronized oscillatory activity at the gamma frequency (30-70 Hz) is thought to be important for information processing in many sensory systems. Here, I used patch-clamp recordings in neuron pairs in rat olfactory bulb slices to assess the mechanisms underlying such "gamma" activity in the olfactory system. Patterne...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.11.038

    authors: Schoppa NE

    更新日期:2006-01-19 00:00:00

  • Targeted disruption of Ca(2+)-calmodulin signaling in Drosophila growth cones leads to stalls in axon extension and errors in axon guidance.

    abstract::Ca(2+)-calmodulin (CaM) function was selectively disrupted in a specific subset of growth cones in transgenic Drosophila embryos in which a specific enhancer element drives the expression of the kinesin motor domain fused to a CaM antagonist peptide (kinesin-antagonist or KA, which blocks CaM binding to target protein...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(95)90239-2

    authors: VanBerkum MF,Goodman CS

    更新日期:1995-01-01 00:00:00

  • Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity.

    abstract::To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the brain reward system, we undertook a phenotype-driven approach using genome-wide microarray profiling of striatal transcripts from three genetic and one pharmacological mouse models of psychostimulant or dopamine supersensitivity...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(04)00048-0

    authors: Yao WD,Gainetdinov RR,Arbuckle MI,Sotnikova TD,Cyr M,Beaulieu JM,Torres GE,Grant SG,Caron MG

    更新日期:2004-02-19 00:00:00

  • Two-back makes step forward in brain imaging genomics.

    abstract::The combination of brain imaging and genetics promises to identify neural mechanisms underlying complex traits such as cognition and psychiatric disorder. The study by Heck et al. (2014) in this issue of Neuron highlights voltage-gated cation channel activity as a likely link and culprit. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2014.02.023

    authors: McIntosh A,Deary I,Porteous DJ

    更新日期:2014-03-05 00:00:00