Abstract:
:Prime diagnostic criteria for drug addiction include uncontrollable urges to obtain drugs and reduced behavioral responding for natural rewards. Cellular adaptations in the glutamate projection from the prefrontal cortex (PFC) to the nucleus accumbens have been discovered in rats withdrawn from cocaine that may underlie these cardinal features of addiction. A hypothesis is articulated that altered G protein signaling in the PFC focuses behavior on drug-associated stimuli, while dysregulated PFC-accumbens synaptic glutamate transmission underlies the unmanageable motivation to seek drugs.
journal_name
Neuronjournal_title
Neuronauthors
Kalivas PW,Volkow N,Seamans Jdoi
10.1016/j.neuron.2005.02.005subject
Has Abstractpub_date
2005-03-03 00:00:00pages
647-50issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(05)00121-2journal_volume
45pub_type
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