Abstract：
:Commissural axons are attracted to the midline intermediate target by chemoattractants, but upon crossing the midline they switch off responsiveness to attractants and switch on responsiveness to midline repellents, which expel the axons from the midline and enable them to move on. Here we show that midline exit also requires the stimulation of axon outgrowth by Stem Cell Factor (SCF, also known as Steel Factor). SCF is expressed by midline floor plate cells, and its receptor Kit, a receptor tyrosine kinase, is expressed by commissural axons. In Steel and Kit mutant mice, the majority of commissural axons line up transiently at the contralateral edge of the floor plate, showing a delay in midline exit. In vitro, SCF selectively promotes outgrowth of postcrossing, but not precrossing, commissural axons. Our findings identify SCF as a guidance cue in the CNS, and provide evidence that exiting intermediate targets requires activation of outgrowth-promoting mechanisms.
journal_name
Neuronjournal_title
Neuronauthors
Gore BB,Wong KG,Tessier-Lavigne Mdoi
10.1016/j.neuron.2008.01.006subject
Has Abstractpub_date
2008-02-28 00:00:00pages
501-10issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(08)00037-8journal_volume
57pub_type
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