A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission.

abstract：:Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...

journal_title：Neuron

authors： Okun M

更新日期：2020-01-22 00:00:00

abstract：:The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate ...

journal_title：Neuron

authors： Pearson RA,Dale N,Llaudet E,Mobbs P

更新日期：2005-06-02 00:00:00

abstract：:The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autis...

journal_title：Neuron

authors： Samuels IS,Saitta SC,Landreth GE

更新日期：2009-01-29 00:00:00

abstract：:Hundreds of G protein-coupled receptors (GPCRs) and at least six GPCR kinases have been identified, but the only GPCR phosphatase that has been definitively demonstrated is the rhodopsin phosphatase encoded by the rdgC locus of Drosophila. Mutations in rdgC result in defects in termination of the light response and ca...

journal_title：Neuron

authors： Lee SJ,Montell C

更新日期：2001-12-20 00:00:00

abstract：:The mechanisms generating precise connections between specific thalamic nuclei and cortical areas remain poorly understood. Using axon tracing analysis of ephrin/Eph mutant mice, we provide in vivo evidence that Eph receptors in the thalamus and ephrins in the cortex control intra-areal topographic mapping of thalamoc...

journal_title：Neuron

authors： Dufour A,Seibt J,Passante L,Depaepe V,Ciossek T,Frisén J,Kullander K,Flanagan JG,Polleux F,Vanderhaeghen P

更新日期：2003-07-31 00:00:00

abstract：:Fear is a graded central motive state ranging from mild to intense. As threat intensity increases, fear transitions from discriminative to generalized. The circuit mechanisms that process threats of different intensity are not well resolved. Here, we isolate a unique population of locally projecting neurons in the cen...

journal_title：Neuron

authors： Sanford CA,Soden ME,Baird MA,Miller SM,Schulkin J,Palmiter RD,Clark M,Zweifel LS

更新日期：2017-01-04 00:00:00

abstract：:A fundamental question in developmental neuroscience is how a collection of progenitor cells proliferates and differentiates to create a brain of the appropriate size and cellular composition. To address this issue, we devised lineage-tracing assays in developing zebrafish embryos to reconstruct entire retinal lineage...

journal_title：Neuron

authors： He J,Zhang G,Almeida AD,Cayouette M,Simons BD,Harris WA

更新日期：2012-09-06 00:00:00

abstract：:Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presy...

journal_title：Neuron

authors： Varoqueaux F,Aramuni G,Rawson RL,Mohrmann R,Missler M,Gottmann K,Zhang W,Südhof TC,Brose N

更新日期：2006-09-21 00:00:00

abstract：:Propagation in higher animals requires the efficient and accurate display of innate mating behaviors. In Drosophila melanogaster, male courtship consists of a stereotypic sequence of behaviors involving multiple sensory modalities, such as vision, audition, and chemosensation. For example, taste bristles located in th...

journal_title：Neuron

authors： Bray S,Amrein H

更新日期：2003-09-11 00:00:00

abstract：:Apart from being a common feature of mental illness, auditory hallucinations provide an intriguing model for the study of internally generated sensory perceptions that are attributed to external sources. Until now, the knowledge about the cortical network that supports such hallucinations has been restricted by method...

journal_title：Neuron

authors： Dierks T,Linden DE,Jandl M,Formisano E,Goebel R,Lanfermann H,Singer W

更新日期：1999-03-01 00:00:00

abstract：:Nearly 25 years ago, the shared interests of psychologists and biologists in understanding the neural basis of social behavior led to the inception of social neuroscience. In the past decade, this field has exploded, in large part due to the infusion of studies that use fMRI. At the same time, tensions have arisen abo...

journal_title：Neuron

authors： Stanley DA,Adolphs R

更新日期：2013-10-30 00:00:00

abstract：:In this issue of Neuron, Costa et al. (2017) introduce a theoretical framework that predicts the ratio of presynaptic and postsynaptic changes taking place during LTP and LTD and show that these processes co-operate so as to optimize the postsynaptic response statistics. ...

journal_title：Neuron

authors： Poirazi P,Kastellakis G

更新日期：2017-09-27 00:00:00

abstract：:The immediate early gene Arc (also Arg3.1) produces rapid changes in synaptic properties that are linked to de novo translation. Here we develop a novel translation reporter that exploits the rapid maturation and "flash" kinetics of Gaussia luciferase (Gluc) to visualize Arc translation. Following glutamate stimulatio...

journal_title：Neuron

authors： Na Y,Park S,Lee C,Kim DK,Park JM,Sockanathan S,Huganir RL,Worley PF

更新日期：2016-08-03 00:00:00

abstract：:Grid cells, border cells, head-directions cells, and conjunctive correlates found in the Medial Entorhinal Cortex (MEC) indicate the presence of highly specialized neural circuits that process allocentric space. New technical advancements, as described by Tang et al. (2014) in this issue, offer an integrated approach ...

journal_title：Neuron

authors： Savelli F,Knierim JJ

更新日期：2014-12-17 00:00:00

abstract：:Cortical development depends on the active integration of cell-autonomous and extrinsic cues, but the coordination of these processes is poorly understood. Here, we show that the apical complex protein Pals1 and Pten have opposing roles in localizing the Igf1R to the apical, ventricular domain of cerebral cortical pro...

journal_title：Neuron

authors： Lehtinen MK,Zappaterra MW,Chen X,Yang YJ,Hill AD,Lun M,Maynard T,Gonzalez D,Kim S,Ye P,D'Ercole AJ,Wong ET,LaMantia AS,Walsh CA

更新日期：2011-03-10 00:00:00

abstract：:Modulation of evoked quantal transmitter release by protein kinase C (PKC) was investigated at an identified cholinergic neuro-neuronal synapse of the Aplysia buccal ganglion. Evoked acetylcholine release was increased by a diacylglycerol analog that activates PKC and was decreased by H-7, a blocker of PKC. FLRFamide ...

journal_title：Neuron

authors： Fossier P,Baux G,Tauc L

更新日期：1990-10-01 00:00:00

abstract：:Since the early days of research into language and the brain, word meaning was assumed to be processed in specific brain regions, which most modern neuroscientists localize to the left temporal lobe. Here we use event-related fMRI to show that action words referring to face, arm, or leg actions (e.g., to lick, pick, o...

journal_title：Neuron

authors： Hauk O,Johnsrude I,Pulvermüller F

更新日期：2004-01-22 00:00:00

abstract：:Using exome sequencing, we identified a p.R191Q amino acid change in the valosin-containing protein (VCP) gene in an Italian family with autosomal dominantly inherited amyotrophic lateral sclerosis (ALS). Mutations in VCP have previously been identified in families with Inclusion Body Myopathy, Paget disease, and Fron...

journal_title：Neuron

authors： Johnson JO,Mandrioli J,Benatar M,Abramzon Y,Van Deerlin VM,Trojanowski JQ,Gibbs JR,Brunetti M,Gronka S,Wuu J,Ding J,McCluskey L,Martinez-Lage M,Falcone D,Hernandez DG,Arepalli S,Chong S,Schymick JC,Rothstein J,Landi

更新日期：2010-12-09 00:00:00

abstract：:The development and homeostasis of neurons relies heavily on the selective targeting of vesicles into axon and dendrites. Microtubule-based motor proteins play an important role in polarized transport; however, the sorting mechanism to exclude dendritic cargo from the axon is unclear. We show that the dynein regulator...

journal_title：Neuron

authors： Kuijpers M,van de Willige D,Freal A,Chazeau A,Franker MA,Hofenk J,Rodrigues RJ,Kapitein LC,Akhmanova A,Jaarsma D,Hoogenraad CC

更新日期：2016-02-03 00:00:00

abstract：:The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates many fundamental brain functions. Studies in humans have suggested that strong LC activation might shift network connectivity to favor salience processing. To causally test this hypothesis, we use a mouse model to study the eff...

journal_title：Neuron

authors： Zerbi V,Floriou-Servou A,Markicevic M,Vermeiren Y,Sturman O,Privitera M,von Ziegler L,Ferrari KD,Weber B,De Deyn PP,Wenderoth N,Bohacek J

更新日期：2019-08-21 00:00:00

abstract：:Excessive grooming behaviors, cleansing rituals, and self-mutilation are important features of a range of neuropsychiatric diseases including obsessive compulsive (OC)-spectrum disorders. In this issue of Neuron, Greer and Capecchi (2002) report that Hoxb8 mutant mice exhibit this behavioral phenotype. These Hoxb8 mut...

journal_title：Neuron

authors： Graybiel AM,Saka E

更新日期：2002-01-03 00:00:00

abstract：:RNA transport is an important and fundamental event for local protein synthesis, especially in neurons. RNA is transported as large granules, but little is known about them. Here, we isolated a large RNase-sensitive granule (size: 1000S approximately) as a binding partner of conventional kinesin (KIF5). We identified ...

journal_title：Neuron

authors： Kanai Y,Dohmae N,Hirokawa N

更新日期：2004-08-19 00:00:00

abstract：:Inhibition of granule cells plays a key role in gating the flow of signals into the cerebellum, and it is thought that Golgi cells are the only interneurons that inhibit granule cells. Here we show that Purkinje cells, the sole output neurons of the cerebellar cortex, also directly inhibit granule cells via their axon...

journal_title：Neuron

authors： Guo C,Witter L,Rudolph S,Elliott HL,Ennis KA,Regehr WG

更新日期：2016-09-21 00:00:00

abstract：:The development of GABAergic inhibitory circuits is shaped by neural activity, but the underlying mechanisms are unclear. Here, we demonstrate a novel function of GABA in regulating GABAergic innervation in the adolescent brain, when GABA is mainly known as an inhibitory transmitter. Conditional knockdown of the rate-...

journal_title：Neuron

authors： Chattopadhyaya B,Di Cristo G,Wu CZ,Knott G,Kuhlman S,Fu Y,Palmiter RD,Huang ZJ

更新日期：2007-06-21 00:00:00

abstract：:Much evidence indicates that prefrontal cortex plays an important role in long-term recognition memory processes. Here, we report primate prefrontal neuronal responses carrying information necessary for long-term visual recognition memory. The responses of many neurons signaled stimulus familiarity even when the perio...

journal_title：Neuron

authors： Xiang JZ,Brown MW

更新日期：2004-06-10 00:00:00

abstract：:In this issue of Neuron, Katsuki and colleagues show that cell-autonomous mechanisms divide Drosophila axons into proximal and distal compartments. Axon guidance receptors selectively localize to one compartment. A diffusion barrier exists near the compartment boundary, suggesting that it may have properties like thos...

journal_title：Neuron

authors： Wright AP,Zinn K

更新日期：2009-10-29 00:00:00

abstract：:The distribution of the synaptic vesicle-associated phosphoprotein synapsin I after electrical stimulation of the frog neuromuscular junction was investigated by immunogold labeling and compared with the distribution of the integral synaptic vesicle protein synaptophysin. In resting terminals both proteins were locali...

journal_title：Neuron

authors： Torri Tarelli F,Bossi M,Fesce R,Greengard P,Valtorta F

更新日期：1992-12-01 00:00:00

abstract：:The adipocyte-derived hormone leptin decreases body weight in part by activating the sympathetic nervous system, resulting in increased thermogenesis and energy expenditure. We investigated hypothalamic pathways underlying leptin's effects on stimulating the sympathetic nervous system. We found that leptin activates n...

journal_title：Neuron

authors： Elias CF,Lee C,Kelly J,Aschkenasi C,Ahima RS,Couceyro PR,Kuhar MJ,Saper CB,Elmquist JK

更新日期：1998-12-01 00:00:00

abstract：:Presynaptic neurexins (Nrxs) and type IIa receptor-type protein tyrosine phosphatases (RPTPs) organize synapses through a network of postsynaptic ligands. We show that leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) differentially engage the protein domains of Nrx but require its heparan sulfate (HS) modi...

journal_title：Neuron

authors： Roppongi RT,Dhume SH,Padmanabhan N,Silwal P,Zahra N,Karimi B,Bomkamp C,Patil CS,Champagne-Jorgensen K,Twilley RE,Zhang P,Jackson MF,Siddiqui TJ

更新日期：2020-04-08 00:00:00

abstract：:I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybd...

journal_title：Neuron

authors： Chen H,Kim LA,Rajan S,Xu S,Goldstein SA

更新日期：2003-09-25 00:00:00