Abstract：
:Cortical development depends on the active integration of cell-autonomous and extrinsic cues, but the coordination of these processes is poorly understood. Here, we show that the apical complex protein Pals1 and Pten have opposing roles in localizing the Igf1R to the apical, ventricular domain of cerebral cortical progenitor cells. We found that the cerebrospinal fluid (CSF), which contacts this apical domain, has an age-dependent effect on proliferation, much of which is attributable to Igf2, but that CSF contains other signaling activities as well. CSF samples from patients with glioblastoma multiforme show elevated Igf2 and stimulate stem cell proliferation in an Igf2-dependent manner. Together, our findings demonstrate that the apical complex couples intrinsic and extrinsic signaling, enabling progenitors to sense and respond appropriately to diffusible CSF-borne signals distributed widely throughout the brain. The temporal control of CSF composition may have critical relevance to normal development and neuropathological conditions.
journal_name
Neuronjournal_title
Neuronauthors
Lehtinen MK,Zappaterra MW,Chen X,Yang YJ,Hill AD,Lun M,Maynard T,Gonzalez D,Kim S,Ye P,D'Ercole AJ,Wong ET,LaMantia AS,Walsh CAdoi
10.1016/j.neuron.2011.01.023subject
Has Abstractpub_date
2011-03-10 00:00:00pages
893-905issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(11)00071-7journal_volume
69pub_type
杂志文章相关文献
NEURON文献大全abstract：:Human vision adapts to the contrast of patterns by changing its sensitivity, but the origins of this perceptual adaptation have been disputed. In this issue of Neuron, Solomon et al. show that contrast adaptation in the primate arises mostly in the retina for the magnocellular pathway and mostly in the cortex for the ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(04)00187-4
更新日期：2004-04-08 00:00:00
abstract：:How primates perceive objects along with their detailed features remains a mystery. This ability to make fine visual discriminations depends upon a high-acuity analysis of spatial frequency (SF) along the visual hierarchy from V1 to inferotemporal cortex. By studying the transformation of SF across macaque parafoveal ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.03.009
更新日期：2018-04-18 00:00:00
abstract：:The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a network structure composed of multiple types of neurons. Here, we report that mice with a Bmal1 deletion specific to arginine vasopressin (AVP)-producing neurons showed marked lengthening in the free-running period and activity time of...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.02.005
更新日期：2015-03-04 00:00:00
abstract：:The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Car...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.03.017
更新日期：2016-05-04 00:00:00
abstract：:Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter mi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.03.026
更新日期：2009-05-14 00:00:00
abstract：:Following alpha-latrotoxin application to cerebellar slices, bursts of miniature IPSCs (mIPSCs) were observed in interneurons of the molecular layer. Within bursts, mIPSCs had homogeneous amplitudes with a narrow Gaussian distribution. Analysis of successive event amplitudes revealed an interaction between consecutive...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80354-2
更新日期：1997-07-01 00:00:00
abstract：:Opioid neuropeptides and their receptors are evolutionarily conserved neuromodulatory systems that profoundly influence behavior. In dorsal striatum, which expresses the endogenous opioid enkephalin, patches (or striosomes) are limbic-associated subcompartments enriched in mu opioid receptors. The functional implicati...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.11.010
更新日期：2015-12-16 00:00:00
abstract：:mRNAs for AMPA- and kainate-preferring glutamate receptor subunits are expressed abundantly in the CNS, yet functional studies of neurons and glia from brain suggest selective expression of AMPA receptors. We now show that glial cells of the O-2A lineage express rapidly desensitizing responses to kainate, mRNAs for Gl...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90277-1
更新日期：1994-02-01 00:00:00
abstract：:The forebrain is one of most complex cellular structures known. Two phenomena that enable this complexity are tangential migrations that mix neurons from distinct progenitor fields, and axon guidance across intervening, noninnervated fields. A new paper in Cell by López-Bendito et al. has discovered the convergence of...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2006.04.001
更新日期：2006-04-20 00:00:00
abstract：:A series of recent papers highlight a prominent role for ubiquitin in the formation and function of neural circuits. These new results focus attention on the molecular remodeling that occurs at various decision points in the life of growth cones and synapses. ...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(02)00943-1
更新日期：2002-09-26 00:00:00
abstract：:The Drosophila circadian oscillator consists of interlocked period (per)/timeless (tim) and Clock (Clk) transcriptional/translational feedback loops. Within these feedback loops, CLK and CYCLE (CYC) activate per and tim transcription at the same time as they repress Clk transcription, thus controlling the opposite cyc...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00002-3
更新日期：2003-01-23 00:00:00
abstract：:Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and expli...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.08.024
更新日期：2006-11-09 00:00:00
abstract：:Which neurons in the brain "decide" to initiate particular behaviors in response to sensory information? In this issue of Neuron, two papers (Kohatsu et al. and von Philipsborn et al.) identify candidates in the courtship circuitry of Drosophila. The activity of these neurons is both regulated by sex pheromones and ne...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2011.01.021
更新日期：2011-02-10 00:00:00
abstract：:Acquisition of new learning is challenged by the phenomenon of proactive interference (PI), which occurs when previous learning disrupts later learning. Whereas human neuroimaging studies have focused on the cortical contributions to interference resolution, animal studies demonstrate that efficient resolution of PI d...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(04)00080-7
更新日期：2004-03-04 00:00:00
abstract：:Argiotoxin, a component of the spider venom from Argiope lobata, blocks AMPA receptor channels expressed in homomeric and heteromeric configuration in Xenopus oocytes. Argiotoxin acts as an open channel blocker in a voltage-dependent manner and discriminates between the functionally diverse AMPA receptors. Importantly...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90061-u
更新日期：1993-06-01 00:00:00
abstract：:Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose and many neuropsychiatric comorbidities. Uncovering the mechanisms responsible for pain-induced negative affect is critical in addressing these comorbid outcomes...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.02.029
更新日期：2019-05-08 00:00:00
abstract：:Glutamate receptors mediate the majority of rapid excitatory synaptic transmission in the central nervous system (CNS) and play important roles in synaptic plasticity and neuronal development. Recently, protein-protein interactions with the C-terminal domain of glutamate receptor subunits have been shown to be involve...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80548-6
更新日期：1998-08-01 00:00:00
abstract：:Sympathetic neurons in culture die by apoptosis when deprived of nerve growth factor (NGF). We used this model of programmed cell death to study the mechanisms that mediate neuronal apoptosis. Cultured sympathetic neurons were injected with copper/zinc superoxide dismutase protein (SOD) or with an expression vector co...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90287-2
更新日期：1995-02-01 00:00:00
abstract：:Presynaptic neurexins (Nrxs) and type IIa receptor-type protein tyrosine phosphatases (RPTPs) organize synapses through a network of postsynaptic ligands. We show that leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) differentially engage the protein domains of Nrx but require its heparan sulfate (HS) modi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.01.003
更新日期：2020-04-08 00:00:00
abstract：:The nicotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the free energy of binding of the neurotransmitter acetylcholine into opening of its central pore. Here we present the first high-resolution structure of the receptor type found in muscle-endplate membrane and in the muscle-derived e...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.03.012
更新日期：2020-06-17 00:00:00
abstract：:The relative timing of presynaptic and postsynaptic spikes plays a critical role in activity-induced synaptic modification. Here we examined whether plasticity of orientation selectivity in the visual cortex depends on stimulus timing. Repetitive pairing of visual stimuli at two orientations induced a shift in orienta...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00460-3
更新日期：2001-10-25 00:00:00
abstract：:We describe the isolation and characterization of a cDNA encoding the alpha subunit of a new voltage-sensitive sodium channel, microI, from rat skeletal muscle. The 1840 amino acid microI peptide is homologous to alpha subunits from rat brain, but, like the protein from eel electroplax, lacks an extended (approximatel...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(89)90113-x
更新日期：1989-07-01 00:00:00
abstract：:The visual cortex has the capacity for experience-dependent change, or cortical plasticity, that is retained throughout life. Plasticity is invoked for encoding information during perceptual learning, by internally representing the regularities of the visual environment, which is useful for facilitating intermediate-l...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.06.030
更新日期：2012-07-26 00:00:00
abstract：:Cigarette smokers tend to drink more alcohol than their nonsmoking peers. In this issue of Neuron, Doyon et al. (2013) found that nicotine-induced increases in stress hormones can augment ethanol self-administration in rats, suggesting that a drug interaction may contribute to this phenomenon. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2013.07.018
更新日期：2013-08-07 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.02.008
更新日期：2008-04-24 00:00:00
abstract：:Music can be seen as a model system for understanding gene × environment interactions and how these can influence neurocognitive development. The concept of musicality, however, is underspecified and not well understood. Here, I propose a framework for defining musicality to provide a foundation for studying the contr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.01.017
更新日期：2012-02-23 00:00:00
abstract：:Brain nicotinic acetylcholine receptors (nAChRs) are made up of protein subunits that differ from those constituting muscle nAChRs. To characterize the physiological properties of one class of avian brain nicotinic receptor, we injected the nuclei of Xenopus oocytes with full-length cDNAs for the ligand binding (alpha...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90132-8
更新日期：1988-11-01 00:00:00
abstract：:In this issue of Neuron, McGinty et al. (2013) report that the activity of cue-responsive neurons in the rat nucleus accumbens predicts the vigor of the subsequent approach movement. The characterization of this network state between motivation and action lends novel mechanistic insight to a spectrum of cue-elicited b...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2013.05.021
更新日期：2013-06-05 00:00:00
abstract：:During the metamorphosis of the Xenopus laevis retina, thyroid hormone (TH) preferentially induces ventral ciliary marginal zone (CMZ) cells to both increase their proliferation and give rise to ipsilaterally projecting ganglion cells. Here we show that dorsal CMZ cells express type III deiodinase (D3), an enzyme that...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81034-x
更新日期：1999-12-01 00:00:00
abstract：:A recent paper in Nature (Lim et al., 2012) describes the effects of melanocortin receptors in the nucleus accumbens. The studies connect a hypothalamic peptide system with brain reward centers and show effects on specific neuronal populations and behavioral components of mood. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2012.07.018
更新日期：2012-08-09 00:00:00
