Abstract：
:Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, responses observed in hippocampus and striatum were linearly related to the gain in performance observed overnight, but not over the day. Responses in both structures were significantly larger at 24 hr than at 30 min or 5 hr. Additionally, the competitive interaction observed between these structures during training became cooperative overnight. These results stress the importance of both hippocampus and striatum in procedural memory consolidation. Responses in these areas during training seem to condition the overnight memory processing that is associated with a change in their functional interactions. These results show that both structures interact during motor sequence consolidation to optimize subsequent behavior.
journal_name
Neuronjournal_title
Neuronauthors
Albouy G,Sterpenich V,Balteau E,Vandewalle G,Desseilles M,Dang-Vu T,Darsaud A,Ruby P,Luppi PH,Degueldre C,Peigneux P,Luxen A,Maquet Pdoi
10.1016/j.neuron.2008.02.008subject
Has Abstractpub_date
2008-04-24 00:00:00pages
261-72issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(08)00130-Xjournal_volume
58pub_type
杂志文章相关文献
NEURON文献大全abstract：:We induced and characterized a recessive lethal mutation, nic-1, in zebrafish that blocks the function of muscle acetylcholine (ACh) receptors. Homozygous nic-1 embryos are nonmotile and fail to respond to exogenous application of cholinergic agonists, although their muscles contract in response to direct electrical s...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90139-7
更新日期：1990-06-01 00:00:00
abstract：:It has been unclear whether the hippocampus is uniquely important for episodic memory (memory for events that are specific to time and place) or whether the hippocampus is also important for learning and remembering facts (semantic memory). In two studies, we assessed the capacity for semantic memory in patients with ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00146-6
更新日期：2003-04-10 00:00:00
abstract：:Synaptotagmin-1 and -2 are known Ca(2+) sensors for fast synchronous neurotransmitter release, but the potential Ca(2+)-sensor functions of other synaptotagmins in release remain uncharacterized. We now show that besides synaptotagmin-1 and -2, only synaptotagmin-9 (also called synaptotagmin-5) mediates fast Ca(2+) tr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.05.004
更新日期：2007-05-24 00:00:00
abstract：:In the mammalian olfactory bulb, signal processing is mediated by synaptic interactions between dendrites. Glutamate released from mitral cell dendrites excites dendritic spines of granule cells, which in turn release GABA back onto the mitral cell dendrites, forming a reciprocal synaptic pair. This feedback synaptic ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81065-x
更新日期：2000-03-01 00:00:00
abstract：UNLABELLED:Human induced pluripotent stem cells (iPSCs) from a healthy 86-year-old male were differentiated into neural stem cells and grafted into adult immunodeficient rats after spinal cord injury. Three months after C5 lateral hemisections, iPSCs survived and differentiated into neurons and glia and extended tens o...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.07.014
更新日期：2014-08-20 00:00:00
abstract：:Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presy...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.09.003
更新日期：2006-09-21 00:00:00
abstract：:We have investigated the specification of noradrenergic neurotransmitter identity in neural crest stem cells (NCSCs). Retroviral expression of both wild-type and dominant-negative forms of the paired homeodomain transcription factor Phox2a indicates a crucial and direct role for this protein (and/or the closely relate...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80729-1
更新日期：1999-04-01 00:00:00
abstract：:In this issue of Neuron, Ambrozkiewicz et al. (2018) define a new molecular circuit controlling neuronal polarization and migration through the transcription factor SOX9 to coordinate the production of regulators of both protein synthesis and degradation. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.11.022
更新日期：2018-12-05 00:00:00
abstract：:Molecular determinants of threshold sensitivity of mammalian mechanoreceptors are unknown. Here, we identify a mechanosensitive (MS) K(+) current (IKmech) that governs mechanical threshold and adaptation of distinct populations of mechanoreceptors. Toxin profiling and transgenic mouse studies indicate that IKmech is c...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.12.035
更新日期：2013-03-06 00:00:00
abstract：:Here we define activities of RIM-binding protein (RBP) that are essential for baseline neurotransmission and presynaptic homeostatic plasticity. At baseline, rbp mutants have a ∼10-fold decrease in the apparent Ca(2+) sensitivity of release that we attribute to (1) impaired presynaptic Ca(2+) influx, (2) looser coupli...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.01.024
更新日期：2015-03-04 00:00:00
abstract：:Currents mediated by a glutamate transporter cloned from human motor cortex were measured in Xenopus oocytes. In the absence of glutamate, voltage jumps induced Na(+)-dependent capacitive currents that were blocked by kainate, a competitive transport antagonist. The pre-steady-state currents can be described by an ord...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90340-2
更新日期：1995-05-01 00:00:00
abstract：:DNA methylation is a covalent chemical modification of DNA catalyzed by DNA methyltransferases (DNMTs). DNA methylation is associated with transcriptional silencing and has been studied extensively as a lifelong molecular information storage mechanism put in place during development. Here we report that DNMT gene expr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.02.022
更新日期：2007-03-15 00:00:00
abstract：:We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90152-x
更新日期：1994-01-01 00:00:00
abstract：:In the brain, enormous numbers of neurons have functional individuality and distinct circuit specificities. Clustered Protocadherins (Pcdhs), diversified cell-surface proteins, are stochastically expressed by alternative promoter choice and affect dendritic arborization in individual neurons. Here we found that the Pc...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.02.005
更新日期：2014-04-02 00:00:00
abstract：:To survive, humans must estimate their own ability and the abilities of others. We found that, although people estimated their abilities on the basis of their own performance in a rational manner, their estimates of themselves were partly merged with the performance of others. Reciprocally, their ability estimates for...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.06.022
更新日期：2016-07-20 00:00:00
abstract：:Changes in the response to release of a single synaptic vesicle have generally been attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now demonstrates that alterations in vesicle filling also contribute to changes in quantal size. Receptors are not saturated at many synapses, a...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2007.09.001
更新日期：2007-09-20 00:00:00
abstract：:The ability of vertebrates to detect and avoid damaging extremes of temperature depends on activation of ion channels belonging to the thermo-TRP family. Injury or inflammation causes the release of inflammatory mediators which lower the threshold for detection of painful levels of heat, a process known as heat hypera...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.05.015
更新日期：2008-08-14 00:00:00
abstract：:Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced. Here we asked if cortical stimulation could provide artificial feedback during operant conditioning of cortical neurons. Simultaneous two-photon imaging and real-t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.01.023
更新日期：2017-02-22 00:00:00
abstract：:Synaptic scaling is a key homeostatic plasticity mechanism and is thought to be involved in the regulation of cortical activity levels. Here we investigated the spatial scale of homeostatic changes in spine size following sensory deprivation in a subset of inhibitory (layer 2/3 GAD65-positive) and excitatory (layer 5 ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.09.052
更新日期：2017-11-15 00:00:00
abstract：:Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holorece...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.10.029
更新日期：2017-12-06 00:00:00
abstract：:How a single fertilized cell generates diverse neuronal populations has been a fundamental biological problem since the 19(th) century. Classical histological methods revealed that postmitotic neurons are produced in a precise temporal and spatial order from germinal cells lining the cerebral ventricles. In the 20(th)...
journal_title：Neuron
pub_type： 历史文章,杂志文章
doi：10.1016/j.neuron.2011.05.005
更新日期：2011-05-26 00:00:00
abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) has been described as a biochemical switch that is turned on by increases in intracellular calcium to mediate synaptic plasticity. Here, we show that reductions in CaMKII activity trigger persistent increases in intrinsic excitability. In spontaneously firing ves...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.04.009
更新日期：2005-05-19 00:00:00
abstract：:Calcium-activated potassium channels were expressed in Xenopus oocytes by injection of RNA transcribed in vitro from complementary DNAs derived from the slo locus of Drosophila melanogaster. Many cDNAs were found that encode closely related proteins of about 1200 aa. The predicted sequences of these proteins differ by...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90160-f
更新日期：1992-08-01 00:00:00
abstract：:A multitude of synaptic proteins interact at the active zones of nerve terminals to achieve the high temporal precision of neurotransmitter release in synchrony with action potentials. Though synaptotagmin has been recognized as the Ca2+ sensor for synchronous release, it may have additional roles of action. We addres...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.07.028
更新日期：2009-08-27 00:00:00
abstract：:Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiolog...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.07.019
更新日期：2018-07-25 00:00:00
abstract：:Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) report in Nature that primates evolved novel transcriptional responses to neuronal activity, including induction of musclin/osteocrin (OSTN), which may regulate specialized aspects of prim...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.11.024
更新日期：2016-11-23 00:00:00
abstract：:Visinin is a retinal cone cell-specific protein (molecular weight 24,000, pI 5.1). To investigate its function, visinin cDNA was isolated from a chick retinal lambda gt11 cDNA library, using anti-visinin serum. The beta-galactosidase-visinin fusion protein was used for purifying epitope-selected antibody. The purified...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90059-o
更新日期：1990-03-01 00:00:00
abstract：:Critical periods are developmental time windows during which neuronal connections are shaped by experience. In this issue of Neuron, Davis et al. (2015) show that transplantation of embryonic inhibitory interneurons can reactivate critical period plasticity and reverse amblyopia in the visual cortex of adult mice. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2015.05.003
更新日期：2015-05-20 00:00:00
abstract：:Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical gl...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2009.02.015
更新日期：2009-03-12 00:00:00
abstract：:M-current is widespread in the nervous system. It stabilizes cell excitability, and its suppression by muscarinic receptor activation underlies slow synaptic transmission in sympathetic neurons. Suppression of M-current was one of the first examples of neuromodulation of a potassium current, but the mechanism is not u...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90272-s
更新日期：1993-07-01 00:00:00
