Abstract：
:Glutamate receptors mediate the majority of rapid excitatory synaptic transmission in the central nervous system (CNS) and play important roles in synaptic plasticity and neuronal development. Recently, protein-protein interactions with the C-terminal domain of glutamate receptor subunits have been shown to be involved in the modulation of receptor function and clustering at excitatory synapses. In this paper, we have found that the N-ethylmaleimide-sensitive factor (NSF), a protein involved in membrane fusion events, specifically interacts with the C terminus of the GluR2 and GluR4c subunits of AMPA receptors in vitro and in vivo. Moreover, intracellular perfusion of neurons with a synthetic peptide that competes with the interaction of NSF and AMPA receptor subunits rapidly decreases the amplitude of miniature excitatory postsynaptic currents (mEPSCs), suggesting that NSF regulates AMPA receptor function.
journal_name
Neuronjournal_title
Neuronauthors
Song I,Kamboj S,Xia J,Dong H,Liao D,Huganir RLdoi
10.1016/s0896-6273(00)80548-6subject
Has Abstractpub_date
1998-08-01 00:00:00pages
393-400issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80548-6journal_volume
21pub_type
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