Abstract:
:Accurate motion detection requires neural circuitry that compensates for global visual field motion. Select subtypes of retinal ganglion cells perceive image motion and connect to the accessory optic system (AOS) in the brain, which generates compensatory eye movements that stabilize images during slow visual field motion. Here, we show that the murine transmembrane semaphorin 6A (Sema6A) is expressed in a subset of On direction-selective ganglion cells (On DSGCs) and is required for retinorecipient axonal targeting to the medial terminal nucleus (MTN) of the AOS. Plexin A2 and A4, two Sema6A binding partners, are expressed in MTN cells, attract Sema6A(+) On DSGC axons, and mediate MTN targeting of Sema6A(+) RGC projections. Furthermore, Sema6A/Plexin-A2/A4 signaling is required for the functional output of the AOS. These data reveal molecular mechanisms underlying the assembly of AOS circuits critical for moving image perception.
journal_name
Neuronjournal_title
Neuronauthors
Sun LO,Brady CM,Cahill H,Al-Khindi T,Sakuta H,Dhande OS,Noda M,Huberman AD,Nathans J,Kolodkin ALdoi
10.1016/j.neuron.2015.03.064subject
Has Abstractpub_date
2015-05-20 00:00:00pages
971-984issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00288-3journal_volume
86pub_type
杂志文章相关文献
NEURON文献大全abstract::Two studies in this issue of Neuron challenge widely held assumptions about the role of positive feedback in recurrent neuronal networks. Goldman shows that such feedback is not necessary for memory maintenance in a neural integrator, and Murphy and Miller show that it is not necessary for amplification of orientation...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.02.006
更新日期:2009-02-26 00:00:00
abstract::Calcium current types expressed in vertebrate spinal motoneurons have not been previously resolved. We have resolved three types in chick limb motoneurons identified by retrograde labeling and report that dramatic changes in their expression take place during development in vivo. T-, N-, and L-type calcium currents we...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90052-4
更新日期:1989-06-01 00:00:00
abstract::Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.12.012
更新日期:2008-02-07 00:00:00
abstract::Although pain is defined as a sensory and emotional experience, it is traditionally researched and clinically treated separately from emotion. Conceptual and mechanistic relationships between these constructs highlight the need for better understanding of their bi-directional influences and the value of bridging the p...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2020.05.024
更新日期:2020-07-08 00:00:00
abstract::The molecular specification of central circuits that coordinate expression of innate behaviors in response to specific sensory cues from the environment remains a puzzle. In this issue of Neuron, Choi, Dong, and colleagues used expression profiling and genetic axonal tracing to visualize a hypothalamic point of conver...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2005.05.001
更新日期:2005-05-19 00:00:00
abstract::Predictive coding posits that neural systems make forward-looking predictions about incoming information. Neural signals contain information not about the currently perceived stimulus, but about the difference between the observed and the predicted stimulus. We propose to extend the predictive coding framework from hi...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2013.08.020
更新日期:2013-09-04 00:00:00
abstract::Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limit...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80254-8
更新日期:1996-12-01 00:00:00
abstract::Dopamine (DA) transmission mediates numerous aspects of behavior. Although DA release is strongly linked to firing of DA neurons, recent developments indicate the importance of presynaptic modulation at striatal dopaminergic terminals. The endocannabinoid (eCB) system regulates DA release and is a canonical gatekeeper...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.11.012
更新日期:2017-12-06 00:00:00
abstract::Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...
journal_title:Neuron
pub_type: 临床试验,杂志文章
doi:10.1016/s0896-6273(01)00199-4
更新日期:2001-01-01 00:00:00
abstract::Long-term memory and synaptic plasticity are thought to require the synthesis of new proteins at activated synapses. The CPEB family of RNA binding proteins, including Drosophila Orb2, has been implicated in this process. The precise mechanism by which these molecules regulate memory formation is however poorly unders...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.08.028
更新日期:2012-10-18 00:00:00
abstract::Neurotrophins and tyrosine receptor kinase (Trk) receptors are expressed in skeletal muscle, but it is unclear what functional role Trk-mediated signaling plays during postnatal life. Full-length TrkB (trkB.FL) as well as truncated TrkB (trkB.t1) were found to be localized primarily to the postsynaptic acetylcholine r...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81113-7
更新日期:1999-11-01 00:00:00
abstract::Excessive grooming behaviors, cleansing rituals, and self-mutilation are important features of a range of neuropsychiatric diseases including obsessive compulsive (OC)-spectrum disorders. In this issue of Neuron, Greer and Capecchi (2002) report that Hoxb8 mutant mice exhibit this behavioral phenotype. These Hoxb8 mut...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(01)00575-x
更新日期:2002-01-03 00:00:00
abstract::Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. We examined the effects of cadherin blockage on synaptogenesis in cultured hippocampal neurons. This blockade resulted in alterations of dendritic spin...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00748-1
更新日期:2002-07-03 00:00:00
abstract::Spontaneous fMRI fluctuations are organized in large-scale spatiotemporal structures, or resting-state networks (RSN). However, it is unknown how task performance affects RSN dynamics. We use MEG to measure slow (∼0.1 Hz) coherent fluctuations of band-limited power (BLP), a robust correlate of RSN, during rest and mov...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.06.022
更新日期:2013-08-21 00:00:00
abstract::We describe the genetic and kinetic defects in a congenital myasthenic syndrome caused by heteroallelic mutations of the acetylcholine receptor (AChR) epsilon subunit gene. The mutations are an in-frame duplication of six residues in the long cytoplasmic loop (epsilon1254ins18) and a cysteine-loop null mutation (epsil...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80996-4
更新日期:1998-03-01 00:00:00
abstract::Historical milestones in neuroscience have come in diverse forms, ranging from the resolution of specific biological mysteries via creative experimentation to broad technological advances allowing neuroscientists to ask new kinds of questions. The continuous development of tools is driven with a special necessity by t...
journal_title:Neuron
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neuron.2013.10.032
更新日期:2013-10-30 00:00:00
abstract::Sustained rate-coded signals encode many types of sensory modalities. Some sensory synapses possess specialized ribbon structures, which tether vesicles, to enable high-frequency signaling. However, central synapses lack these structures, yet some can maintain signaling over a wide bandwidth. To analyze the underlying...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.10.026
更新日期:2010-11-18 00:00:00
abstract::The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00236-7
更新日期:2001-03-01 00:00:00
abstract::Protrusive behavior of dendritic spines on developing neurons has been previously suggested to mediate the formation of new axodendritic synaptic contacts. A study by Zito et al. in this issue of Neuron links actin polymerization in dendritic spines with the motility that the spines exhibit and the synapses that they ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2004.10.003
更新日期:2004-10-14 00:00:00
abstract::N-type calcium channels play a dominant role in controlling synaptic transmission in many peripheral neurons. Transmitter release from mammalian central nerve terminals, however, is relatively resistant to the N channel antagonist omega-conotoxin GVIA. We studied the sensitivity of glutamatergic synaptic transmission ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90119-c
更新日期:1993-11-01 00:00:00
abstract::Neurons compensate their synaptic strengths to global changes in network activity. In this issue of Neuron, Lee et al. (2013) provide evidence in mature hippocampal networks that this homeostatic plasticity is achieved uniquely at the mossy fiber synapses on CA3 neurons. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2012.12.024
更新日期:2013-01-09 00:00:00
abstract::The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the medial ganglionic eminence, the NKX2-1 transcription factor controls regional id...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.08.020
更新日期:2016-09-21 00:00:00
abstract::Accumulation of beta-amyloid protein (Abeta) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue of Neuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Abeta levels are directly modulated by neurona...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2005.12.005
更新日期:2005-12-22 00:00:00
abstract::Intracortical somatosensory interfaces have now entered the clinical domain. Darie et al. explore the implications of research published in Science Translational Medicine by Flesher et al. (2016), discuss how to design such a system given current technology, and question how to effectively communicate with users about...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.02.008
更新日期:2017-02-22 00:00:00
abstract::GABAergic, somatostatin-containing bitufted interneurons in layer 2/3 of rat neocortex are excited via glutamatergic excitatory postsynaptic potentials (EPSPs) by pyramidal neurons located in the same cortical layer. Pair recordings showed that short bursts of backpropagating dendritic action potentials (APs) reduced ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81044-2
更新日期:1999-12-01 00:00:00
abstract::The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types remains unclear. Here we performed cellular-resolution microendoscopic Ca(2+) imaging from genetica...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.06.021
更新日期:2015-07-15 00:00:00
abstract::It has recently been found that caspases not only function in apoptosis, but are also crucial for nonapoptotic processes such as NMDA receptor-dependent long-term depression (LTD) of synaptic transmission. It remains unknown, however, how caspases are activated and how neurons escape death in LTD. Here we show that ca...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.04.004
更新日期:2011-05-26 00:00:00
abstract::The TRPN1 ion channel has a role in both hearing and bristle mechanosensation in fruit flies and in proprioception in nematodes. In this issue of Neuron, two papers present evidence that TRPN1 is also required for proprioception in fruit fly larvae and that it is a bona fide mechanoreceptor channel for nematode feedin...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2010.07.022
更新日期:2010-08-12 00:00:00
abstract::Charybdotoxin (CTX) blocks high conductance Ca(2+)-activated K+ channels by binding to a receptor site in the externally facing "mouth." Toxin bound to the channel can be destabilized from its site by K+ entering the channel from the opposite, internal, solution. By analyzing point mutants of CTX expressed in E. coli,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90169-e
更新日期:1992-08-01 00:00:00
abstract::We describe the isolation and characterization of a cDNA encoding the alpha subunit of a new voltage-sensitive sodium channel, microI, from rat skeletal muscle. The 1840 amino acid microI peptide is homologous to alpha subunits from rat brain, but, like the protein from eel electroplax, lacks an extended (approximatel...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90113-x
更新日期:1989-07-01 00:00:00