What Is the Relationship between Pain and Emotion? Bridging Constructs and Communities.

abstract：:cGMP has long been suspected to play a role in synaptic plasticity, but the inaccessibility of nerve terminals to electrical recording has impeded tests of this hypothesis. In posterior pituitary nerve terminals, nitric oxide enhanced Ca(2+)-activated K+ channel activity by activating guanylate cyclase and PKG. This e...

journal_title：Neuron

authors： Klyachko VA,Ahern GP,Jackson MB

更新日期：2001-09-27 00:00:00

abstract：:Sensory systems transform the external world into time-varying spike trains. What features of spiking activity are used to guide behavior? In the mouse olfactory bulb, inhalation of different odors leads to changes in the set of neurons activated, as well as when neurons are activated relative to each other (synchrony...

journal_title：Neuron

authors： Gill JV,Lerman GM,Zhao H,Stetler BJ,Rinberg D,Shoham S

更新日期：2020-10-28 00:00:00

abstract：:The blood-brain barrier (BBB) poses a major challenge for developing effective antibody therapies for neurological diseases. Using transcriptomic and proteomic profiling, we searched for proteins in mouse brain endothelial cells (BECs) that could potentially be exploited to transport antibodies across the BBB. Due to ...

journal_title：Neuron

authors： Zuchero YJ,Chen X,Bien-Ly N,Bumbaca D,Tong RK,Gao X,Zhang S,Hoyte K,Luk W,Huntley MA,Phu L,Tan C,Kallop D,Weimer RM,Lu Y,Kirkpatrick DS,Ernst JA,Chih B,Dennis MS,Watts RJ

更新日期：2016-01-06 00:00:00

abstract：:Using primary cultures and immortalized multipotential stem cell lines derived from wild-type and Mash1 mutant neural crest cells, we have analyzed the cellular function of MASH1 in autonomic neurogenesis. We present evidence for the existence of a precursor expressing MASH1 and neuronal markers such as neurofilament,...

journal_title：Neuron

authors： Sommer L,Shah N,Rao M,Anderson DJ

更新日期：1995-12-01 00:00:00

abstract：:The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates many fundamental brain functions. Studies in humans have suggested that strong LC activation might shift network connectivity to favor salience processing. To causally test this hypothesis, we use a mouse model to study the eff...

journal_title：Neuron

authors： Zerbi V,Floriou-Servou A,Markicevic M,Vermeiren Y,Sturman O,Privitera M,von Ziegler L,Ferrari KD,Weber B,De Deyn PP,Wenderoth N,Bohacek J

更新日期：2019-08-21 00:00:00

abstract：:We generated transgenic mice that specifically express foreign genes in myelinating Schwann cells. A 1.1 kb segment of 5' flanking sequence from the rat P0 gene was used to drive expression of the genes encoding human growth hormone (hGH) and bacterial diphtheria toxin A chain (DT-A). The P0-hGH mice expressed hGH in ...

journal_title：Neuron

authors： Messing A,Behringer RR,Hammang JP,Palmiter RD,Brinster RL,Lemke G

更新日期：1992-03-01 00:00:00

abstract：:Heterotrimeric G proteins mediate a variety of signaling processes by coupling seven-transmembrane receptors to intracellular effector molecules. The Drosophila phototransduction cascade is a G protein-coupled signaling cascade that utilizes a phospholipase C (PLC beta) effector. PLC beta has been shown to be activate...

journal_title：Neuron

authors： Scott K,Becker A,Sun Y,Hardy R,Zuker C

更新日期：1995-10-01 00:00:00

abstract：:AMPA-type glutamate receptors (AMPARs) are responsible for a variety of processes in the mammalian brain including fast excitatory neurotransmission, postsynaptic plasticity, or synapse development. Here, with comprehensive and quantitative proteomic analyses, we demonstrate that native AMPARs are macromolecular compl...

journal_title：Neuron

authors： Schwenk J,Harmel N,Brechet A,Zolles G,Berkefeld H,Müller CS,Bildl W,Baehrens D,Hüber B,Kulik A,Klöcker N,Schulte U,Fakler B

更新日期：2012-05-24 00:00:00

abstract：:The mechanisms through which estrogen regulates gonadotropin-releasing hormone (GnRH) neurons to control mammalian ovulation are unknown. We found that estrogen positive feedback to generate the preovulatory gonadotropin surge was normal in estrogen receptor beta knockout (ERbeta) mutant mice, but absent in ERalpha mu...

journal_title：Neuron

authors： Wintermantel TM,Campbell RE,Porteous R,Bock D,Gröne HJ,Todman MG,Korach KS,Greiner E,Pérez CA,Schütz G,Herbison AE

更新日期：2006-10-19 00:00:00

abstract：:Advancing psychiatry requires understanding brain malfunction at a microscopic scale, where neurons and synapses operate under constraints imposed by behavior, cognition, and neural architecture. Nonhuman primates are unmatched in approximating the structural and computational environment of the human brain. ...

journal_title：Neuron

authors： Heilbronner SR,Chafee MV

更新日期：2019-04-03 00:00:00

abstract：:In the hippocampus, gamma power modulation by the theta rhythm is interpreted as the signature of temporally coordinated inputs that reflect ongoing processing. In this issue of Neuron, Lopes-Dos-Santos et al. (2018) develop a new methodology demonstrating that theta cycles can be viewed as individual computational un...

journal_title：Neuron

authors： Bagur S,Benchenane K

更新日期：2018-11-21 00:00:00

abstract：:The structural basis for the synthesis of specific proteins within distinct intraneuronal compartments is unknown. We studied the distribution of poly(A) mRNA within cultured cerebrocortical neurons using high resolution in situ hybridization to identify cytoskeletal components that may anchor mRNA. After 1 day in cul...

journal_title：Neuron

authors： Bassell GJ,Singer RH,Kosik KS

更新日期：1994-03-01 00:00:00

abstract：:Fragile X syndrome is a leading heritable cause of mental retardation that results from the loss of FMR1 gene function. A Drosophila model for Fragile X syndrome, based on the loss of dfmr1 activity, exhibits phenotypes that bear similarity to Fragile X-related symptoms. Herein, we demonstrate that treatment with meta...

journal_title：Neuron

authors： McBride SM,Choi CH,Wang Y,Liebelt D,Braunstein E,Ferreiro D,Sehgal A,Siwicki KK,Dockendorff TC,Nguyen HT,McDonald TV,Jongens TA

更新日期：2005-03-03 00:00:00

abstract：:NCAM 180 isoform null neuromuscular junctions are unable to effectively mobilize and exocytose synaptic vesicles and thus exhibit periods of total transmission failure during high-frequency repetitive stimulation. We have identified a highly conserved C-terminal (KENESKA) domain on NCAM that is required to maintain ef...

journal_title：Neuron

authors： Polo-Parada L,Plattner F,Bose C,Landmesser LT

更新日期：2005-06-16 00:00:00

abstract：:Learning can be characterized as the extraction of reliable predictions about stimulus occurrences from past experience. In two experiments, we investigated the interval of temporal integration of previous learning trials in different brain regions using implicit and explicit Pavlovian fear conditioning with a dynamic...

journal_title：Neuron

authors： Gläscher J,Büchel C

更新日期：2005-07-21 00:00:00

abstract：:Selective synaptic and axonal degeneration are critical aspects of both brain development and neurodegenerative disease. Inhibition of caspase signaling in neurons is a potential therapeutic strategy for neurodegenerative disease, but no neuron-specific modulators of caspase signaling have been described. Using a mass...

journal_title：Neuron

authors： Hertz NT,Adams EL,Weber RA,Shen RJ,O'Rourke MK,Simon DJ,Zebroski H,Olsen O,Morgan CW,Mileur TR,Hitchcock AM,Sinnott Armstrong NA,Wainberg M,Bassik MC,Molina H,Wells JA,Tessier-Lavigne M

更新日期：2019-08-07 00:00:00

abstract：:Deciding between stimuli requires combining their learned value with one's sensory confidence. We trained mice in a visual task that probes this combination. Mouse choices reflected not only present confidence and past rewards but also past confidence. Their behavior conformed to a model that combines signal detection...

journal_title：Neuron

authors： Lak A,Okun M,Moss MM,Gurnani H,Farrell K,Wells MJ,Reddy CB,Kepecs A,Harris KD,Carandini M

更新日期：2020-02-19 00:00:00

abstract：:Motor behaviors recruit task-specific neuronal ensembles in motor cortices, which are consolidated over subsequent learning. However, little is known about the molecules that can identify the participating neurons and predict the outcomes of the consolidation process. Using a mouse rotarod-learning task, we showed tha...

journal_title：Neuron

authors： Cao VY,Ye Y,Mastwal S,Ren M,Coon M,Liu Q,Costa RM,Wang KH

更新日期：2015-06-17 00:00:00

abstract：:Previous work has hinted that prospective and retrospective coding modes exist in hippocampus. Prospective coding is believed to reflect memory retrieval processes, whereas retrospective coding is thought to be important for memory encoding. Here, we show in rats that separate prospective and retrospective modes exist...

journal_title：Neuron

authors： Bieri KW,Bobbitt KN,Colgin LL

更新日期：2014-05-07 00:00:00

abstract：:Both acute and chronic changes in AMPA receptor (AMPAR) localization are critical for synaptic formation, maturation, and plasticity. Here I report that AMPARs are differentially sorted between recycling and degradative pathways following endocytosis. AMPAR sorting occurs in early endosomes and is regulated by synapti...

journal_title：Neuron

authors： Ehlers MD

更新日期：2000-11-01 00:00:00

abstract：:Local axon degeneration is a common pathological feature of many neurodegenerative diseases and peripheral neuropathies. While it is believed to operate with an apoptosis-independent molecular program, the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons,...

journal_title：Neuron

authors： Zhai Q,Wang J,Kim A,Liu Q,Watts R,Hoopfer E,Mitchison T,Luo L,He Z

更新日期：2003-07-17 00:00:00

abstract：:The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate ...

journal_title：Neuron

authors： Pearson RA,Dale N,Llaudet E,Mobbs P

更新日期：2005-06-02 00:00:00

abstract：:Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields have been combined only recently to facilitate novel experiments and measurements in neuroscience. Since tissue-clearing methods were first combined with modernized light-sheet microscopy a decade ago, the performance of both tec...

journal_title：Neuron

authors： Ueda HR,Dodt HU,Osten P,Economo MN,Chandrashekar J,Keller PJ

更新日期：2020-05-06 00:00:00

abstract：:The functional expression of Ca2+-activated K+ channels (KCa) in developing chick ciliary ganglion (CG) neurons requires interactions with target tissues and preganglionic innervation. Here, we show that the stimulatory effects of target tissues are mediated by an isoform of TGFbeta. Exposure of cultured CG neurons to...

journal_title：Neuron

authors： Cameron JS,Lhuillier L,Subramony P,Dryer SE

更新日期：1998-11-01 00:00:00

abstract：:Signaling classically involves the secretion of diverse molecules that bind specific cell-surface receptors and engage intracellular transduction cascades. Some exceptions-namely, lipophilic agents-can cross plasma membranes to bind intracellular receptors and be carried to the nucleus to regulate transcription. Homeo...

journal_title：Neuron

authors： Prochiantz A,Di Nardo AA

更新日期：2015-03-04 00:00:00

abstract：:Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven ...

journal_title：Neuron

authors： Levin N,Dumoulin SO,Winawer J,Dougherty RF,Wandell BA

更新日期：2010-01-14 00:00:00

abstract：:Dynamic rearrangements of axon terminal arbors may be critical for establishing appropriate connections in the developing nervous system. Here, the changes in complex retinal axon arbors in the tecta of live Xenopus larvae were followed during the formation of the topographic retinotectal projection. Three-dimensional...

journal_title：Neuron

authors： O'Rourke NA,Cline HT,Fraser SE

更新日期：1994-04-01 00:00:00

abstract：:Slob is a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium (K(Ca)) channel. A yeast two-hybrid screen with Slob as bait identifies the zeta isoform of 14-3-3 as a Slob-binding protein. Coimmunoprecipitation experiments from Drosophila heads and trans...

journal_title：Neuron

authors： Zhou Y,Schopperle WM,Murrey H,Jaramillo A,Dagan D,Griffith LC,Levitan IB

更新日期：1999-04-01 00:00:00

abstract：:Neurons adapt their synaptic responses to the activity of the underlying network. In this issue of Neuron, Thiagarajan and colleagues report on specific subcellular mechanisms of homeostasis after prolonged neuronal inactivity. The results have important implications not only for neuronal homeostasis but also for furt...

journal_title：Neuron

authors： Gundlfinger A,Schmitz D

更新日期：2005-09-01 00:00:00

abstract：:Synapse-to-nucleus signaling leading to CREB-mediated transcription is important for neuronal plasticity. Nuclear CREB phosphorylation at Ser133 allows convergence of multiple kinase pathways driven by neuronal activity and links them to transcriptional activation. But, can various pathways share a common effector mec...

journal_title：Neuron

authors： Deisseroth K,Tsien RW

更新日期：2002-04-11 00:00:00