Abstract:
:The structural basis for the synthesis of specific proteins within distinct intraneuronal compartments is unknown. We studied the distribution of poly(A) mRNA within cultured cerebrocortical neurons using high resolution in situ hybridization to identify cytoskeletal components that may anchor mRNA. After 1 day in culture, poly(A) mRNA was distributed throughout all of the initial neurites, including the axon-like process. At 4 days in culture, poly(A) mRNA was distributed throughout the cell body and dendritic processes, but confined to the proximal segment of the axon. Poly(A) mRNA was bound to the cytoskeleton as demonstrated by resistance to detergent extraction. Perturbation of microtubules with colchicine resulted in a major reduction of dendritic poly(A) mRNA; however, this distribution was unaffected by cytochalasin. Ultrastructural in situ hybridization revealed that poly(A) mRNA and associated ribosomes were excluded from tightly bundled microtubules.
journal_name
Neuronjournal_title
Neuronauthors
Bassell GJ,Singer RH,Kosik KSdoi
10.1016/0896-6273(94)90213-5subject
Has Abstractpub_date
1994-03-01 00:00:00pages
571-82issue
3eissn
0896-6273issn
1097-4199pii
0896-6273(94)90213-5journal_volume
12pub_type
杂志文章相关文献
NEURON文献大全abstract::Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2010.01.016
更新日期:2010-02-25 00:00:00
abstract::Aβ Immunotherapy is a promising therapeutic approach for Alzheimer's disease. Preclinical studies demonstrate that plaque prevention is possible; however, the more relevant therapeutic removal of existing plaque has proven elusive. Monoclonal antibodies in development target both soluble and insoluble Aβ peptide. We h...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.10.029
更新日期:2012-12-06 00:00:00
abstract::Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81007-7
更新日期:1998-04-01 00:00:00
abstract::Microtubules play an important role in neuronal polarity. In this issue of Neuron, Watabe-Uchida et al. link a novel Rac-mediated pathway that regulates microtubule dynamics to axon formation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2006.08.020
更新日期:2006-09-21 00:00:00
abstract::mRNA coding for brain-derived neurotrophic factor (BDNF) has been detected in cultured L929 fibroblasts, rat dermal fibroblasts, and sciatic nerve Schwann cells, as well as in rat skin. Medium conditioned by cultured fibroblasts and Schwann cells also stimulates neurite growth from retinal explants and promotes the su...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90265-2
更新日期:1991-08-01 00:00:00
abstract::The amplitudes and kinetics of miniature excitatory synaptic currents (MESCs) in mammalian central neurons vary widely. It is unclear whether this variability occurs at each synapse or arises from differences among a heterogeneous population of synapses. Furthermore, it is not known how variability in these currents w...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90073-x
更新日期:1995-07-01 00:00:00
abstract::Commissural axons are attracted to the midline intermediate target by chemoattractants, but upon crossing the midline they switch off responsiveness to attractants and switch on responsiveness to midline repellents, which expel the axons from the midline and enable them to move on. Here we show that midline exit also ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.01.006
更新日期:2008-02-28 00:00:00
abstract::During development, newly born neurons migrate away from their initial birth sites to their final positions in the mature brain. The neurotrophin BDNF has been shown to regulate the migration of granule cells in the cerebellum. The cellular mechanisms that mediate this chemotactic response have not been resolved. In t...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2007.06.025
更新日期:2007-07-05 00:00:00
abstract::We have cloned the rat gene encoding peripherin, a neuronal-specific intermediate filament protein that is NGF-regulated. Determination of the complete sequence, including 821 nucleotides of the 5'-flanking region, allows us to make conclusions about the evolutionary origin of the peripherin gene, its homology with ot...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90228-6
更新日期:1989-01-01 00:00:00
abstract::Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct commitment to glia from multipotent progenitors of the central nervous system. Here we present evidence that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00179-9
更新日期:2001-01-01 00:00:00
abstract::When speaking, we dynamically coordinate movements of our jaw, tongue, lips, and larynx. To investigate the neural mechanisms underlying articulation, we used direct cortical recordings from human sensorimotor cortex while participants spoke natural sentences that included sounds spanning the entire English phonetic i...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.04.031
更新日期:2018-06-06 00:00:00
abstract::In this issue of Neuron, Tufail et al. present an underlying mechanism for microglia-mediated elimination of virally transduced cells in the central nervous system. These findings could contribute to the development of improved gene therapies for various neurological disorders by exploring why microglia destroy viable...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.01.025
更新日期:2017-02-08 00:00:00
abstract::Synaptic activity induces changes in the number of dendritic spines. Here, we report a pathway of regulated endocytosis triggered by arcadlin, a protocadherin induced by electroconvulsive and other excitatory stimuli in hippocampal neurons. The homophilic binding of extracellular arcadlin domains activates TAO2beta, a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.08.020
更新日期:2007-11-08 00:00:00
abstract::Effective error-driven learning benefits from scaling of prediction errors to reward variability. Such behavioral adaptation may be facilitated by neurons coding prediction errors relative to the standard deviation (SD) of reward distributions. To investigate this hypothesis, we required participants to predict the ma...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.04.019
更新日期:2016-06-01 00:00:00
abstract::We have investigated the cell cycle-related mechanisms that lead to the emergence of primate areas 17 and 18. These areas are characterized by striking differences in cytoarchitectonics and neuron number. We show in vivo that (1) area 17 precursors of supragranular neurons exhibit a shorter cell cycle duration, a redu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.06.032
更新日期:2005-08-04 00:00:00
abstract::The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.05.032
更新日期:2018-06-06 00:00:00
abstract::Ionic currents were recorded from Xenopus oocytes injected with RNA isolated from chick or mouse brain. Three currents were studied: a rapid tetrodotoxin-sensitive Na+ current (Ina), an early outward K+ current sensitive to 4-aminopyridine (IA), and an inward current activated by the excitatory amino acid receptor ago...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90153-5
更新日期:1988-12-01 00:00:00
abstract::The carboxyl terminus of presenilin 1 and 2 (PS1 and PS2) binds to the neuron-specific cell adhesion molecule telencephalin (TLN) in the brain. PS1 deficiency results in the abnormal accumulation of TLN in a yet unidentified intracellular compartment. The first transmembrane domain and carboxyl terminus of PS1 form a ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00512-8
更新日期:2001-11-20 00:00:00
abstract::Neuromodulators regulate circuits throughout the nervous system, and revealing the cell types and stimulus conditions controlling their release is vital to understanding their function. The effects of the neuromodulator nitric oxide (NO) have been studied in many circuits, including in the vertebrate retina, where it ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.09.047
更新日期:2018-12-05 00:00:00
abstract::Many high threshold, voltage-gated Ca2+ channels, including the dihydropyridine-sensitive class (L-type), inactivate in response not only to voltage, but also to entry of Ca2+. Despite the physiological importance of this Ca(2+)-sensitive inactivation, its molecular mechanism is understood only in broad outline. We no...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90446-4
更新日期:1994-06-01 00:00:00
abstract::Glucose-inhibited neurons orchestrate behavior and metabolism according to body energy levels, but how glucose inhibits these cells is unknown. We studied glucose inhibition of orexin/hypocretin neurons, which promote wakefulness (their loss causes narcolepsy) and also regulate metabolism and reward. Here we demonstra...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.04.032
更新日期:2006-06-01 00:00:00
abstract::Neural ensembles oscillate across a broad range of frequencies and are transiently coupled or "bound" together when people attend to a stimulus, perceive, think, and act. This is a dynamic, self-assembling process, with parts of the brain engaging and disengaging in time. But how is it done? The theory of Coordination...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2013.12.022
更新日期:2014-01-08 00:00:00
abstract::Neuropilins are receptors for class 3 secreted semaphorins, most of which can function as potent repulsive axon guidance cues. We have generated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus. Many Npn-2 mutant mice are viable into adulthood, allowing us to assess the role of Npn-2 in axon guidance ev...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80869-7
更新日期:2000-01-01 00:00:00
abstract::We have made little recent progress developing effective new treatments for neuropsychiatric and neurodevelopmental disorders. Novel molecular mechanisms have been identified, but have not translated into the clinic. We suggest an alternative: combinations of treatments targeting different aspects of final common path...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.10.006
更新日期:2014-11-05 00:00:00
abstract::Deciding when to exploit what is already known and when to explore new possibilities is crucial for adapting to novel and dynamic environments. Using reinforcement-based decision making, Costa et al. (2019) in this issue of Neuron find that neurons in the amygdala and ventral-striatum differentially signal the benefit...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.07.021
更新日期:2019-08-07 00:00:00
abstract::Memory distortions and illusions have been thoroughly documented in psychological studies, but little is known about the neuroanatomical correlates of true and false memories. Vivid but illusory memories can be induced by asking people whether they recall or recognize words that were not previously presented, but are ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80158-0
更新日期:1996-08-01 00:00:00
abstract::Nogo-A, a reticulon protein expressed by oligodendrocytes, contributes to the axonal growth inhibitory action of central myelin in growth cone collapse and neurite outgrowth in vitro assays, and antibody and inhibitor studies have implicated a role for Nogo in regeneration in the adult CNS in vivo. Three independent l...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00233-2
更新日期:2003-04-24 00:00:00
abstract::We describe the extent to which presynaptic structures at the embryonic neuromuscular junction of Drosophila can form in mutants where development of postsynaptic somatic muscles is affected. Although twist mutant embryos lack mesoderm, motor axons still grow out of the CNS and form morphologically normal presynaptic ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80195-6
更新日期:1996-10-01 00:00:00
abstract::We describe recent progress toward defining neuronal cell types in the mouse retina and attempt to extract lessons that may be generally useful in the mammalian brain. Achieving a comprehensive catalog of retinal cell types now appears within reach, because researchers have achieved consensus concerning two fundamenta...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2014.08.054
更新日期:2014-09-17 00:00:00
abstract::The brain mechanisms underlying visual object categorization remain unclear. In this issue of Neuron, Minamimoto and colleagues introduce a novel task that associates each category with a different incentive value, and they demonstrate that it can be learned within a single session even after ablation of the lateral p...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2010.05.012
更新日期:2010-05-27 00:00:00