Public-private partnership: a new engine for translational research in neurosciences.

abstract：:Experience is a powerful sculptor of developing neural connections. In the primary visual cortex (V1), cortical connections are particularly susceptible to the effects of sensory manipulation during a postnatal critical period. At the molecular level, this activity-dependent plasticity requires the transformation of s...

journal_title：Neuron

authors： Taha S,Hanover JL,Silva AJ,Stryker MP

更新日期：2002-10-24 00:00:00

abstract：:Zika virus (ZIVK) represents a new threat to global health, with particular relevance to neuroscientists, due to associated newborn and adult neurological disease. Consequences of vertical infection include microcephaly with brain and eye anomalies, and consequences of adult infection include Guillain-Barré syndrome (...

journal_title：Neuron

authors： Li H,Saucedo-Cuevas L,Shresta S,Gleeson JG

更新日期：2016-12-07 00:00:00

abstract：:Although many studies have identified neural correlates of memory, relatively little is known about the circuit properties connecting single-neuron physiology to behavior. Here we developed a modeling framework to bridge this gap and identify circuit interactions capable of maintaining short-term memory. Unlike typica...

journal_title：Neuron

authors： Fisher D,Olasagasti I,Tank DW,Aksay ER,Goldman MS

更新日期：2013-09-04 00:00:00

abstract：:Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells ...

journal_title：Neuron

authors： Eljaschewitsch E,Witting A,Mawrin C,Lee T,Schmidt PM,Wolf S,Hoertnagl H,Raine CS,Schneider-Stock R,Nitsch R,Ullrich O

更新日期：2006-01-05 00:00:00

abstract：:Previous studies of the ferret visual cortex indicate that the development of direction selectivity requires visual experience. Here, we used two-photon calcium imaging to study the development of direction selectivity in layer 2/3 neurons of the mouse visual cortex in vivo. Surprisingly, just after eye opening nearly...

journal_title：Neuron

authors： Rochefort NL,Narushima M,Grienberger C,Marandi N,Hill DN,Konnerth A

更新日期：2011-08-11 00:00:00

abstract：:Direction selectivity (DS) is an important neuronal property in the visual system, but how DS is generated beyond the retina remains controversial. Here, we report a close correspondence between the preferred direction (PD) and the morphology of DS cells in the optic tectum. Ca(2+) imaging in cells expressing the gene...

journal_title：Neuron

authors： Gabriel JP,Trivedi CA,Maurer CM,Ryu S,Bollmann JH

更新日期：2012-12-20 00:00:00

abstract：:Neurotropic viruses that conditionally infect or replicate in molecularly defined neuronal subpopulations, and then spread transsynaptically, are powerful tools for mapping neural pathways. Genetically targetable retrograde transsynaptic tracer viruses are available to map the inputs to specific neuronal subpopulation...

journal_title：Neuron

authors： Lo L,Anderson DJ

更新日期：2011-12-22 00:00:00

abstract：:LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using genetic and biochemical studies involving Lrrk loss-of-function mutants and Parkinson-related LRRK2(G2019S) gain-of-kinase function, we sh...

journal_title：Neuron

authors： Matta S,Van Kolen K,da Cunha R,van den Bogaart G,Mandemakers W,Miskiewicz K,De Bock PJ,Morais VA,Vilain S,Haddad D,Delbroek L,Swerts J,Chávez-Gutiérrez L,Esposito G,Daneels G,Karran E,Holt M,Gevaert K,Moechars DW,De

更新日期：2012-09-20 00:00:00

abstract：:Spike timing-dependent synaptic plasticity (STDP) serves as a key cellular correlate of associative learning, which is facilitated by elevated attentional and emotional states involving activation of adrenergic signaling. At cellular levels, adrenergic signaling increases dendrite excitability, but the underlying mech...

journal_title：Neuron

authors： Liu Y,Cui L,Schwarz MK,Dong Y,Schlüter OM

更新日期：2017-01-18 00:00:00

abstract：:It has been hypothesized that the direction of synaptic weight change elicited by synaptic activity depends on the magnitude of the activity-dependent rise in intracellular Ca2+ concentration. Several aspects of this hypothesis were examined at the Schaffer collateral CA1 synapse, where both long-term depression (LTD)...

journal_title：Neuron

authors： Cummings JA,Mulkey RM,Nicoll RA,Malenka RC

更新日期：1996-04-01 00:00:00

abstract：:In a recent study in the journal Cell, Tervo et al. (2014) show that animals can implement stochastic choice policies in environments unfavorable to predictive strategies. The shift toward stochastic behavior was driven by noradrenergic signaling in the anterior cingulate cortex. ...

journal_title：Neuron

authors： Akam T,Costa RM

更新日期：2014-10-01 00:00:00

abstract：:In the visual cortex of many mammals, orientation preference changes smoothly along the cortical surface, with the exception of singularities such as pinwheels and fractures. The reason for the existence of these singularities has remained elusive, suggesting that they are developmental artifacts. We show that singula...

journal_title：Neuron

authors： Koulakov AA,Chklovskii DB

更新日期：2001-02-01 00:00:00

abstract：:We recently applied multiplexed seqFISH to profile expressions of hundreds of genes at the single-cell level in situ (Shah et al., 2016) and provided a map of spatial heterogeneity within each subregion, reconciling previously contradictory descriptions of CA1 at lower spatial resolutions. The accompanying Matters Ari...

journal_title：Neuron

authors： Shah S,Lubeck E,Zhou W,Cai L

更新日期：2017-05-17 00:00:00

abstract：:Which neurons in the brain "decide" to initiate particular behaviors in response to sensory information? In this issue of Neuron, two papers (Kohatsu et al. and von Philipsborn et al.) identify candidates in the courtship circuitry of Drosophila. The activity of these neurons is both regulated by sex pheromones and ne...

journal_title：Neuron

authors： Benton R

更新日期：2011-02-10 00:00:00

abstract：:The perception of visual motion is critical for animal navigation, and flies are a prominent model system for exploring this neural computation. In Drosophila, the T4 cells of the medulla are directionally selective and necessary for ON motion behavioral responses. To examine the emergence of directional selectivity, ...

journal_title：Neuron

authors： Strother JA,Wu ST,Wong AM,Nern A,Rogers EM,Le JQ,Rubin GM,Reiser MB

更新日期：2017-04-05 00:00:00

abstract：:The apical tuft of layer 5 pyramidal neurons is innervated by a large number of inhibitory inputs with unknown functions. Here, we studied the functional consequences and underlying molecular mechanisms of apical inhibition on dendritic spike activity. Extracellular stimulation of layer 1, during blockade of glutamate...

journal_title：Neuron

authors： Pérez-Garci E,Gassmann M,Bettler B,Larkum ME

更新日期：2006-05-18 00:00:00

abstract：:We have analyzed alternatively spliced beta amyloid protein precursor (beta APP) mRNAs by using the polymerase chain reaction to amplify beta APP cDNAs produced by reverse transcription. With this approach the three previously characterized beta APP mRNAs (beta APP695, beta APP751, and beta APP770) are readily detecte...

journal_title：Neuron

authors： Golde TE,Estus S,Usiak M,Younkin LH,Younkin SG

更新日期：1990-02-01 00:00:00

abstract：:Given that cocaine induces neuroadaptations through regulation of gene expression, we investigated whether chromatin remodeling at specific gene promoters may be a key mechanism. We show that cocaine induces specific histone modifications at different gene promoters in striatum, a major neural substrate for cocaine's ...

journal_title：Neuron

authors： Kumar A,Choi KH,Renthal W,Tsankova NM,Theobald DE,Truong HT,Russo SJ,Laplant Q,Sasaki TS,Whistler KN,Neve RL,Self DW,Nestler EJ

更新日期：2005-10-20 00:00:00

abstract：:Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic ...

journal_title：Neuron

authors： Frank CA,Kennedy MJ,Goold CP,Marek KW,Davis GW

更新日期：2006-11-22 00:00:00

abstract：:Viral tracers are important tools for neuroanatomical mapping and genetic payload delivery. Genetically modified viruses allow for cell-type-specific targeting and overcome many limitations of non-viral tracers. Here, we summarize the viruses that have been developed for neural circuit mapping, and we provide a primer...

journal_title：Neuron

authors： Xu X,Holmes TC,Luo MH,Beier KT,Horwitz GD,Zhao F,Zeng W,Hui M,Semler BL,Sandri-Goldin RM

更新日期：2020-09-23 00:00:00

abstract：:The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcriptio...

journal_title：Neuron

authors： Nicolas CS,Peineau S,Amici M,Csaba Z,Fafouri A,Javalet C,Collett VJ,Hildebrandt L,Seaton G,Choi SL,Sim SE,Bradley C,Lee K,Zhuo M,Kaang BK,Gressens P,Dournaud P,Fitzjohn SM,Bortolotto ZA,Cho K,Collingridge GL

更新日期：2012-01-26 00:00:00

abstract：:Protein scaffolds are essential for specific and efficient downstream signaling at synapses. Though nicotinic receptors are widely expressed in the nervous system and influence numerous cellular events due in part to their calcium permeability, no scaffolds have yet been identified for the receptors in neurons. Here w...

journal_title：Neuron

authors： Conroy WG,Liu Z,Nai Q,Coggan JS,Berg DK

更新日期：2003-06-05 00:00:00

abstract：:The hippocampus is essential for spatiotemporal cognition. Sequences of neuronal activation provide a substrate for this fundamental function. At the behavioral timescale, these sequences have been shown to occur either in the presence of successive external landmarks or through internal mechanisms within an episodic ...

journal_title：Neuron

authors： Villette V,Malvache A,Tressard T,Dupuy N,Cossart R

更新日期：2015-10-21 00:00:00

abstract：:A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3...

journal_title：Neuron

authors： Zhang Y,Narayan S,Geiman E,Lanuza GM,Velasquez T,Shanks B,Akay T,Dyck J,Pearson K,Gosgnach S,Fan CM,Goulding M

更新日期：2008-10-09 00:00:00

abstract：:Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiolog...

journal_title：Neuron

authors： Yoon KJ,Ming GL,Song H

更新日期：2018-07-25 00:00:00

abstract：:Voltage-gated ion channels generate electrical signals in species from bacteria to man. Their voltage-sensing modules are responsible for initiation of action potentials and graded membrane potential changes in response to synaptic input and other physiological stimuli. Extensive structure-function studies, structure ...

journal_title：Neuron

authors： Catterall WA

更新日期：2010-09-23 00:00:00

abstract：:The alpha subunit of a voltage-sensitive sodium channel characteristic of denervated rat skeletal muscle was cloned and characterized. The cDNA encodes a 2018 amino acid protein (SkM2) that is homologous to other recently cloned sodium channels, including a tetrodotoxin (TTX)-sensitive sodium channel from rat skeletal...

journal_title：Neuron

authors： Kallen RG,Sheng ZH,Yang J,Chen LQ,Rogart RB,Barchi RL

更新日期：1990-02-01 00:00:00

abstract：:Brain areas in the frontal lobe have been implicated in behavioral flexibility and control. The study by Johnston et al. in this issue of Neuron provides novel insights into the roles of the prefrontal and anterior cingulate cortices in controlling behavior. ...

journal_title：Neuron

authors： Rainer G

更新日期：2007-02-01 00:00:00

abstract：:The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autis...

journal_title：Neuron

authors： Samuels IS,Saitta SC,Landreth GE

更新日期：2009-01-29 00:00:00

abstract：:Oxygen (O₂) and carbon dioxide (CO₂) levels vary in different environments and locally fluctuate during respiration and photosynthesis. Recent studies in diverse animals have identified sensory neurons that detect these external variations and direct a variety of behaviors. Detection allows animals to stay within a pr...

journal_title：Neuron

authors： Scott K

更新日期：2011-01-27 00:00:00