Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease.

abstract：:Much evidence indicates that prefrontal cortex plays an important role in long-term recognition memory processes. Here, we report primate prefrontal neuronal responses carrying information necessary for long-term visual recognition memory. The responses of many neurons signaled stimulus familiarity even when the perio...

journal_title：Neuron

authors： Xiang JZ,Brown MW

更新日期：2004-06-10 00:00:00

abstract：:Cognitive control is subjectively costly, suggesting that engagement is modulated in relationship to incentive state. Dopamine appears to play key roles. In particular, dopamine may mediate cognitive effort by two broad classes of functions: (1) modulating the functional parameters of working memory circuits subservin...

journal_title：Neuron

authors： Westbrook A,Braver TS

更新日期：2016-02-17 00:00:00

abstract：:Yoon et al. (2017) uncover a key role for the m6A RNA mark in regulating the timing of cerebral cortex development in mouse and human. This discovery opens new avenues of exploration into how the epitranscriptome helps orchestrate central nervous system formation. ...

journal_title：Neuron

authors： Boles NC,Temple S

更新日期：2017-11-15 00:00:00

abstract：:We report that EphB receptors direct unique axonal behaviors required for mapping the dorsal-ventral (D-V) retinal axis along the lateral-medial (L-M) axis of the superior colliculus (SC). EphBs are expressed in a D-V gradient, ephrin-B1 in a L-M gradient in SC, and ephrin-B3 at its midline. EphBs and ephrin-Bs are ex...

journal_title：Neuron

authors： Hindges R,McLaughlin T,Genoud N,Henkemeyer M,O'Leary D

更新日期：2002-08-01 00:00:00

abstract：:In this issue of Neuron, Wang et al. demonstrate that both cell-intrinsic and -extrinsic factors restrict the myelination of newly regenerated axons. Pharmalogical targeting of GPR17 signaling in oligodendrocyte precursor cells (OPCs) and microglial inhibition of oligodendrocyte maturation together promote robust myel...

journal_title：Neuron

authors： Hilton BJ,Bradke F

更新日期：2020-12-09 00:00:00

abstract：:Small G proteins are an extensive family of proteins that bind and hydrolyze GTP. They are ubiquitous inside cells, regulating a wide range of cellular processes. Recently, many studies have examined the role of small G proteins, particularly the Ras family of G proteins, in memory formation. Once thought to be primar...

journal_title：Neuron

authors： Ye X,Carew TJ

更新日期：2010-11-04 00:00:00

abstract：:The idea that memory is stored in the brain as physical alterations goes back at least as far as Plato, but further conceptualization of this idea had to wait until the 20(th) century when two guiding theories were presented: the "engram theory" of Richard Semon and Donald Hebb's "synaptic plasticity theory." While a ...

journal_title：Neuron

authors： Tonegawa S,Liu X,Ramirez S,Redondo R

更新日期：2015-09-02 00:00:00

abstract：:We have identified factors that control precise motor timing by studying learning in smooth pursuit eye movements. Monkeys tracked a target that moved horizontally for a fixed time interval before changing direction through the addition of a vertical component of motion. After repeated presentations of the same target...

journal_title：Neuron

authors： Medina JF,Carey MR,Lisberger SG

更新日期：2005-01-06 00:00:00

abstract：:Much is known about the functions and properties of neuronal dendrites, but rarely has dendritic activation been monitored while the dendrite performs a computational task. In this issue of Neuron, Bollmann and Engert demonstrate that different regions of a dendrite in the tadpole optic tectum are tuned to stimuli in ...

journal_title：Neuron

authors： Waters J

更新日期：2009-03-26 00:00:00

abstract：:Two mutations in the sodium channel alpha subunit that have been implicated as the cause of periodic paralysis were studied by functional expression in a mammalian cell line. Both mutations disrupted inactivation without affecting the time course of the onset of the sodium current or the single-channel conductance. Th...

journal_title：Neuron

authors： Cannon SC,Strittmatter SM

更新日期：1993-02-01 00:00:00

abstract：:Identifying the spatial organization of tissues at cellular resolution from single-cell gene expression profiles is essential to understanding biological systems. Using an in situ 3D multiplexed imaging method, seqFISH, we identify unique transcriptional states by quantifying and clustering up to 249 genes in 16,958 c...

journal_title：Neuron

authors： Shah S,Lubeck E,Zhou W,Cai L

更新日期：2016-10-19 00:00:00

abstract：:Shaker potassium channels inactivate and recover from inactivation with multiple exponential components, suggesting the presence of multiple inactivation processes. We describe two different types of inactivation in Shaker potassium channels. N-type inactivation can occur as rapidly as a few milliseconds and has been ...

journal_title：Neuron

authors： Hoshi T,Zagotta WN,Aldrich RW

更新日期：1991-10-01 00:00:00

abstract：:Fragile X syndrome is a leading heritable cause of mental retardation that results from the loss of FMR1 gene function. A Drosophila model for Fragile X syndrome, based on the loss of dfmr1 activity, exhibits phenotypes that bear similarity to Fragile X-related symptoms. Herein, we demonstrate that treatment with meta...

journal_title：Neuron

authors： McBride SM,Choi CH,Wang Y,Liebelt D,Braunstein E,Ferreiro D,Sehgal A,Siwicki KK,Dockendorff TC,Nguyen HT,McDonald TV,Jongens TA

更新日期：2005-03-03 00:00:00

abstract：:Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a chang...

journal_title：Neuron

authors： Vinck M,Batista-Brito R,Knoblich U,Cardin JA

更新日期：2015-05-06 00:00:00

abstract：:Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we investigate consequ...

journal_title：Neuron

authors： Judson MC,Wallace ML,Sidorov MS,Burette AC,Gu B,van Woerden GM,King IF,Han JE,Zylka MJ,Elgersma Y,Weinberg RJ,Philpot BD

更新日期：2016-04-06 00:00:00

abstract：:Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced. Here we asked if cortical stimulation could provide artificial feedback during operant conditioning of cortical neurons. Simultaneous two-photon imaging and real-t...

journal_title：Neuron

authors： Prsa M,Galiñanes GL,Huber D

更新日期：2017-02-22 00:00:00

abstract：:Given that cocaine induces neuroadaptations through regulation of gene expression, we investigated whether chromatin remodeling at specific gene promoters may be a key mechanism. We show that cocaine induces specific histone modifications at different gene promoters in striatum, a major neural substrate for cocaine's ...

journal_title：Neuron

authors： Kumar A,Choi KH,Renthal W,Tsankova NM,Theobald DE,Truong HT,Russo SJ,Laplant Q,Sasaki TS,Whistler KN,Neve RL,Self DW,Nestler EJ

更新日期：2005-10-20 00:00:00

abstract：:The discovery of SNCA mutations pathogenic for autosomal-dominant Lewy body Parkinson's disease (PD) in 1997 heralded a revolution in understanding the molecular and genetic basis of PD. Indeed, it now is clear that Lewy body PD is one of many neurodegenerative parkinsonian disorders that result from nigrostriatal deg...

journal_title：Neuron

authors： Forman MS,Lee VM,Trojanowski JQ

更新日期：2005-08-18 00:00:00

abstract：:When learning to achieve a goal through a complex series of actions, humans often group several actions into a subroutine and evaluate whether the subroutine achieved a specific subgoal. A new study reports brain responses consistent with such "hierarchical reinforcement learning." ...

journal_title：Neuron

authors： Behrens TE,Jocham G

更新日期：2011-07-28 00:00:00

abstract：:The trigeminal loop in the brainstem comprises the innermost level of sensorimotor feedback in the rat vibrissa system. Anatomy suggests that this loop relays tactile information from the vibrissae to the motoneurons that control vibrissa movement. We demonstrate, using in vitro and in vivo recordings, that the trigem...

journal_title：Neuron

authors： Nguyen QT,Kleinfeld D

更新日期：2005-02-03 00:00:00

abstract：:Studies on postmortem brains from Parkinson's patients reveal elevated iron in the substantia nigra (SN). Selective cell death in this brain region is associated with oxidative stress, which may be exacerbated by the presence of excess iron. Whether iron plays a causative role in cell death, however, is controversial....

journal_title：Neuron

authors： Kaur D,Yantiri F,Rajagopalan S,Kumar J,Mo JQ,Boonplueang R,Viswanath V,Jacobs R,Yang L,Beal MF,DiMonte D,Volitaskis I,Ellerby L,Cherny RA,Bush AI,Andersen JK

更新日期：2003-03-27 00:00:00

abstract：:We have used immunogold electron microscopy to study the organization of the acetylcholine receptor, 43 kd protein, voltage-sensitive Na+ channel, and ankyrin in the postsynaptic membrane of the rat neuromuscular junction. The acetylcholine receptor and the 43 kd protein are concentrated at the crests of the postsynap...

journal_title：Neuron

authors： Flucher BE,Daniels MP

更新日期：1989-08-01 00:00:00

abstract：:Activity is known to be important for the refinement of neural connections in the developing brain. In this issue of Neuron, Hanson and Landmesser provide evidence that GABA-dependent spontaneous bursting of motor neurons in the embryonic spinal cord is required for the correct execution of an early axon pathfinding d...

journal_title：Neuron

authors： Goulding M

更新日期：2004-09-02 00:00:00

abstract：:Properly functional CNS circuits depend on inhibitory interneurons that in turn rely upon activity-dependent gene expression for morphological development, connectivity, and excitatory-inhibitory coordination. Despite its importance, excitation-transcription coupling in inhibitory interneurons is poorly understood. We...

journal_title：Neuron

authors： Cohen SM,Ma H,Kuchibhotla KV,Watson BO,Buzsáki G,Froemke RC,Tsien RW

更新日期：2016-04-20 00:00:00

abstract：:Among the diverse interneuron subtypes in the neocortex, chandelier cells (ChCs) are the only population that selectively innervate pyramidal neurons (PyNs) at their axon initial segment (AIS), the site of action potential initiation, allowing them to exert powerful control over PyN output. Yet, mechanisms underlying ...

journal_title：Neuron

authors： Tai Y,Gallo NB,Wang M,Yu JR,Van Aelst L

更新日期：2019-04-17 00:00:00

abstract：:Experimental evidence shows that the inability to attribute mental states, such as desires and beliefs, to self and others (mentalizing) explains the social and communication impairments of individuals with autism. Brain imaging studies in normal volunteers highlight a circumscribed network that is active during menta...

journal_title：Neuron

authors： Frith U

更新日期：2001-12-20 00:00:00

abstract：:The mechanism coupling exocytosis and endocytosis remains to be elucidated at central synapses. Here, we show that the mechanism linking these two processes is dependent on microdomain-[Ca2+](i) similar to that which triggers exocytosis, as well as the exocytotic protein synaptobrevin/VAMP. Furthermore, block of endoc...

journal_title：Neuron

authors： Hosoi N,Holt M,Sakaba T

更新日期：2009-07-30 00:00:00

abstract：:The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving ...

journal_title：Neuron

authors： Kim D,Cheong E,Shin HS

更新日期：2018-06-06 00:00:00

abstract：:Glucose-inhibited neurons orchestrate behavior and metabolism according to body energy levels, but how glucose inhibits these cells is unknown. We studied glucose inhibition of orexin/hypocretin neurons, which promote wakefulness (their loss causes narcolepsy) and also regulate metabolism and reward. Here we demonstra...

journal_title：Neuron

authors： Burdakov D,Jensen LT,Alexopoulos H,Williams RH,Fearon IM,O'Kelly I,Gerasimenko O,Fugger L,Verkhratsky A

更新日期：2006-06-01 00:00:00

abstract：:Molecular determinants of threshold sensitivity of mammalian mechanoreceptors are unknown. Here, we identify a mechanosensitive (MS) K(+) current (IKmech) that governs mechanical threshold and adaptation of distinct populations of mechanoreceptors. Toxin profiling and transgenic mouse studies indicate that IKmech is c...

journal_title：Neuron

authors： Hao J,Padilla F,Dandonneau M,Lavebratt C,Lesage F,Noël J,Delmas P

更新日期：2013-03-06 00:00:00