Caught on film: the secret lives of dendrites in the tadpole optic tectum.

Abstract:

:Much is known about the functions and properties of neuronal dendrites, but rarely has dendritic activation been monitored while the dendrite performs a computational task. In this issue of Neuron, Bollmann and Engert demonstrate that different regions of a dendrite in the tadpole optic tectum are tuned to stimuli in different locations of the visual field. Their study is the first direct demonstration that dendritic regions act as semi-independent functional units during sensory processing in a vertebrate central nervous system.

journal_name

Neuron

journal_title

Neuron

authors

Waters J

doi

10.1016/j.neuron.2009.03.009

subject

Has Abstract

pub_date

2009-03-26 00:00:00

pages

813-4

issue

6

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(09)00208-6

journal_volume

61

pub_type

评论,杂志文章

相关文献

NEURON文献大全
  • Differential distribution of Ca2+-activated K+ channel splice variants among hair cells along the tonotopic axis of the chick cochlea.

    abstract::We have cloned from the receptor epithelium of the chick cochlea a family of alternatively spliced cDNAs derived from cslo, which encodes a Ca2+-activated K+ channel like those shown to help determine the resonant frequency of electrically tuned hair cells. Our results from PCRs using template RNAs from both tonotopic...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80398-0

    authors: Navaratnam DS,Bell TJ,Tu TD,Cohen EL,Oberholtzer JC

    更新日期:1997-11-01 00:00:00

  • Distribution of Na+ channels and ankyrin in neuromuscular junctions is complementary to that of acetylcholine receptors and the 43 kd protein.

    abstract::We have used immunogold electron microscopy to study the organization of the acetylcholine receptor, 43 kd protein, voltage-sensitive Na+ channel, and ankyrin in the postsynaptic membrane of the rat neuromuscular junction. The acetylcholine receptor and the 43 kd protein are concentrated at the crests of the postsynap...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(89)90029-9

    authors: Flucher BE,Daniels MP

    更新日期:1989-08-01 00:00:00

  • Theory of mind: a neural prediction problem.

    abstract::Predictive coding posits that neural systems make forward-looking predictions about incoming information. Neural signals contain information not about the currently perceived stimulus, but about the difference between the observed and the predicted stimulus. We propose to extend the predictive coding framework from hi...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2013.08.020

    authors: Koster-Hale J,Saxe R

    更新日期:2013-09-04 00:00:00

  • An inside look at hippocampal silent cells.

    abstract::Hippocampal pyramidal cells can be divided into place cells, which fire action potentials when an animal is in specific locations, and silent cells, which are not spatially selective. In this issue of Neuron, Epsztein et al. find intracellular differences between place and silent cells by using whole-cell recordings i...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2011.03.015

    authors: Ferguson JE,Jackson JC,Redish AD

    更新日期:2011-04-14 00:00:00

  • Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies.

    abstract::The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Car...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.03.017

    authors: Gai Y,Liu Z,Cervantes-Sandoval I,Davis RL

    更新日期:2016-05-04 00:00:00

  • The maintenance of LTP at hippocampal mossy fiber synapses is independent of sustained presynaptic calcium.

    abstract::We have examined the role of presynaptic residual calcium in maintaining long-term changes in synaptic efficacy observed at mossy fiber synapses between hippocampal dentate granule cells and CA3 pyramidal cells. Calcium concentrations in individual mossy fiber terminals in hippocampal slice were optically measured wit...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(91)90297-d

    authors: Regehr WG,Tank DW

    更新日期:1991-09-01 00:00:00

  • Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance.

    abstract::Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays of neuronal survival and growth cone chemotropism. Mutational analysis indicates that coactivation of phospholipase C-gamma (PLC-gamma) and phosphoinositide 3-kinase (PI3-kinase) by specific ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80760-6

    authors: Ming G,Song H,Berninger B,Inagaki N,Tessier-Lavigne M,Poo M

    更新日期:1999-05-01 00:00:00

  • The Biology of Huntingtin.

    abstract::Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative disorder Huntington's disease (HD). The gene encoding huntingtin, HTT, and its dominantly inherited mutation were identified more than 20 years ago...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2016.02.003

    authors: Saudou F,Humbert S

    更新日期:2016-03-02 00:00:00

  • Developing with BDNF: a moving experience.

    abstract::During development, newly born neurons migrate away from their initial birth sites to their final positions in the mature brain. The neurotrophin BDNF has been shown to regulate the migration of granule cells in the cerebellum. The cellular mechanisms that mediate this chemotactic response have not been resolved. In t...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2007.06.025

    authors: Kaplan DR,Miller FD

    更新日期:2007-07-05 00:00:00

  • Reinforcing rhythms in the sleeping brain with a computerized metronome.

    abstract::Sleep has many inherent benefits, including an important role in memory consolidation. In this issue of Neuron, Ngo et al. (2013b) demonstrate that appropriately timed sounds delivered during sleep can invigorate electrophysiological oscillations conducive to memory stabilization. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2013.04.032

    authors: Oudiette D,Santostasi G,Paller KA

    更新日期:2013-05-08 00:00:00

  • Sex Differences in Susceptibility to Depression: A Role for LncRNAs.

    abstract::In this issue of Neuron, Issler et al. (2020) have identified the neuronal, long intergenic noncoding RNA LINC00473 as a potential molecular risk factor for the increased susceptibility for depression in females. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2020.05.016

    authors: Gururajan A

    更新日期:2020-06-17 00:00:00

  • Cortical maps and white matter tracts following long period of visual deprivation and retinal image restoration.

    abstract::Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2009.12.006

    authors: Levin N,Dumoulin SO,Winawer J,Dougherty RF,Wandell BA

    更新日期:2010-01-14 00:00:00

  • Altering cortical connectivity: remediation-induced changes in the white matter of poor readers.

    abstract::Neuroimaging studies using diffusion tensor imaging (DTI) have revealed regions of cerebral white matter with decreased microstructural organization (lowerfractional anisotropy or FA) among poor readers. We examined whether 100 hr of intensive remedial instruction affected the white matter of 8- to 10-year-old poor re...

    journal_title:Neuron

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.neuron.2009.10.018

    authors: Keller TA,Just MA

    更新日期:2009-12-10 00:00:00

  • Connecting the dots: from actin polymerization to synapse formation.

    abstract::Protrusive behavior of dendritic spines on developing neurons has been previously suggested to mediate the formation of new axodendritic synaptic contacts. A study by Zito et al. in this issue of Neuron links actin polymerization in dendritic spines with the motility that the spines exhibit and the synapses that they ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2004.10.003

    authors: Dunaevsky A

    更新日期:2004-10-14 00:00:00

  • EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.

    abstract::EPAC proteins are the guanine nucleotide exchange factors that act as the intracellular receptors for cyclic AMP. Two variants of EPAC genes including EPAC1 and EPAC2 are cloned and are widely expressed throughout the brain. But, their functions in the brain remain unknown. Here, we genetically delete EPAC1 (EPAC1(-/-...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.02.003

    authors: Yang Y,Shu X,Liu D,Shang Y,Wu Y,Pei L,Xu X,Tian Q,Zhang J,Qian K,Wang YX,Petralia RS,Tu W,Zhu LQ,Wang JZ,Lu Y

    更新日期:2012-02-23 00:00:00

  • Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites.

    abstract::The immediate early gene Arc (also Arg3.1) produces rapid changes in synaptic properties that are linked to de novo translation. Here we develop a novel translation reporter that exploits the rapid maturation and "flash" kinetics of Gaussia luciferase (Gluc) to visualize Arc translation. Following glutamate stimulatio...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.06.017

    authors: Na Y,Park S,Lee C,Kim DK,Park JM,Sockanathan S,Huganir RL,Worley PF

    更新日期:2016-08-03 00:00:00

  • Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions.

    abstract::RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2019.03.014

    authors: Nussbacher JK,Tabet R,Yeo GW,Lagier-Tourenne C

    更新日期:2019-04-17 00:00:00

  • Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons.

    abstract::Synaptotagmin-1 and -2 are known Ca(2+) sensors for fast synchronous neurotransmitter release, but the potential Ca(2+)-sensor functions of other synaptotagmins in release remain uncharacterized. We now show that besides synaptotagmin-1 and -2, only synaptotagmin-9 (also called synaptotagmin-5) mediates fast Ca(2+) tr...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2007.05.004

    authors: Xu J,Mashimo T,Südhof TC

    更新日期:2007-05-24 00:00:00

  • Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes.

    abstract::Blood-feeding mosquitoes survive by feeding on nectar for metabolic energy but require a blood meal to develop eggs. Aedes aegypti females must accurately discriminate blood and nectar because each meal promotes mutually exclusive feeding programs with distinct sensory appendages, meal sizes, digestive tract targets, ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2020.09.019

    authors: Jové V,Gong Z,Hol FJH,Zhao Z,Sorrells TR,Carroll TS,Prakash M,McBride CS,Vosshall LB

    更新日期:2020-12-23 00:00:00

  • Time Warping Reveals Hidden Features of Neuronal Population Responses.

    abstract::Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2019.12.010

    authors: Okun M

    更新日期:2020-01-22 00:00:00

  • An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales.

    abstract::Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2018.03.003

    authors: Octeau JC,Chai H,Jiang R,Bonanno SL,Martin KC,Khakh BS

    更新日期:2018-04-04 00:00:00

  • Bad Ac-etylated Tau.

    abstract::By using a tau construct with two mimicked acetylation sites as identified in AD brains, Tracy et al. (2016) found that acetylated tau promotes synaptic dysfunction through disruption of postsynaptic KIBRA signaling pathways, actin dynamics, and AMPA receptor trafficking. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2016.04.008

    authors: Hettinger JC,Cirrito JR

    更新日期:2016-04-20 00:00:00

  • An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis.

    abstract::Mammalian neurogenesis is determined by an interplay between intrinsic genetic mechanisms and extrinsic cues such as growth factors. Here we have defined a signaling cascade, a MEK-C/EBP pathway, that is essential for cortical progenitor cells to become postmitotic neurons. Inhibition of MEK or of the C/EBP family of ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(02)01026-7

    authors: Ménard C,Hein P,Paquin A,Savelson A,Yang XM,Lederfein D,Barnabé-Heider F,Mir AA,Sterneck E,Peterson AC,Johnson PF,Vinson C,Miller FD

    更新日期:2002-11-14 00:00:00

  • Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body.

    abstract::In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.04.034

    authors: Perisse E,Owald D,Barnstedt O,Talbot CB,Huetteroth W,Waddell S

    更新日期:2016-06-01 00:00:00

  • The Theta Rhythm Mixes and Matches Gamma Oscillations Cycle by Cycle.

    abstract::In the hippocampus, gamma power modulation by the theta rhythm is interpreted as the signature of temporally coordinated inputs that reflect ongoing processing. In this issue of Neuron, Lopes-Dos-Santos et al. (2018) develop a new methodology demonstrating that theta cycles can be viewed as individual computational un...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2018.11.008

    authors: Bagur S,Benchenane K

    更新日期:2018-11-21 00:00:00

  • Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others.

    abstract::At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic nerve to the brain. Available strategies of promoting axon regeneration act on only some of these types. Here we tested the hypothesis that overexpressing developmentally important transcription factors in adult RGCs could repr...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2017.05.035

    authors: Norsworthy MW,Bei F,Kawaguchi R,Wang Q,Tran NM,Li Y,Brommer B,Zhang Y,Wang C,Sanes JR,Coppola G,He Z

    更新日期:2017-06-21 00:00:00

  • Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology.

    abstract::Spinocerebellar ataxia type 1 (SCA1), due to the expansion of a polyglutamine repeat within the ubiquitously expressed Ataxin-1 protein, leads to the premature degeneration of Purkinje cells (PCs), the cause of which is poorly understood. Here, we identified the unique proteomic signature of Sca1(154Q/2Q) PCs at an ea...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2015.11.033

    authors: Ruegsegger C,Stucki DM,Steiner S,Angliker N,Radecke J,Keller E,Zuber B,Rüegg MA,Saxena S

    更新日期:2016-01-06 00:00:00

  • Normal patterns of spontaneous activity are required for correct motor axon guidance and the expression of specific guidance molecules.

    abstract::Rhythmic spontaneous electrical activity occurs in many parts of the developing nervous system, where it plays essential roles in the refinement of neural connections. By blocking or slowing this bursting activity, via in ovo drug applications at precise developmental periods, we show that such activity is also requir...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2004.08.018

    authors: Hanson MG,Landmesser LT

    更新日期:2004-09-02 00:00:00

  • The lh3 Glycosyltransferase Directs Target-Selective Peripheral Nerve Regeneration.

    abstract::Functional PNS regeneration requires injured axons to return to their original synaptic targets, yet the mechanisms underlying target-selective regeneration have remained elusive. Using live-cell imaging in zebrafish we find that regenerating motor axons exhibit a strong preference for their original muscle territory ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2015.10.004

    authors: Isaacman-Beck J,Schneider V,Franzini-Armstrong C,Granato M

    更新日期:2015-11-18 00:00:00

  • Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation.

    abstract::Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamica...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2009.05.008

    authors: Zolles G,Wenzel D,Bildl W,Schulte U,Hofmann A,Müller CS,Thumfart JO,Vlachos A,Deller T,Pfeifer A,Fleischmann BK,Roeper J,Fakler B,Klöcker N

    更新日期:2009-06-25 00:00:00