Abstract:
:Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays of neuronal survival and growth cone chemotropism. Mutational analysis indicates that coactivation of phospholipase C-gamma (PLC-gamma) and phosphoinositide 3-kinase (PI3-kinase) by specific cytoplasmic domains of TrkA is essential for triggering chemoattraction of the growth cone in an NGF gradient. Uniform exposure of TrkA-expressing neurons to NGF resulted in a cross-desensitization of turning responses induced by a gradient of netrin-1, brain-derived neurotrophic factor (BDNF), or myelin-associated glycoprotein (MAG) but not by a gradient of collapsin-1/semaphorin III/D or neurotrophin-3 (NT-3). These results, together with the effects of pharmacological inhibitors, support the notion that there are common cytosolic signaling pathways for two separate groups of guidance cues, one of which requires coactivation of PLC-gamma and PI3-kinase pathways.
journal_name
Neuronjournal_title
Neuronauthors
Ming G,Song H,Berninger B,Inagaki N,Tessier-Lavigne M,Poo Mdoi
10.1016/s0896-6273(00)80760-6subject
Has Abstractpub_date
1999-05-01 00:00:00pages
139-48issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80760-6journal_volume
23pub_type
杂志文章相关文献
NEURON文献大全abstract::In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.03.001
更新日期:2010-03-25 00:00:00
abstract::In mammals, the osmolality of the extracellular fluid (ECF) is highly stable despite radical changes in salt/water intake and excretion. Afferent systems are required to detect hypo- or hyperosmotic shifts in the ECF to trigger homeostatic control of osmolality. In humans, a pressor reflex is triggered by simply drink...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.12.028
更新日期:2011-01-27 00:00:00
abstract::A circadian clock governs most aspects of mammalian behavior. Although its properties are in part genetically determined, altered light-dark environment can change circadian period length through a mechanism requiring de novo DNA methylation. We show here that this mechanism is mediated not via cell-autonomous clock p...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.12.022
更新日期:2017-01-18 00:00:00
abstract::Spine morphology is regulated by intracellular signals, like PKC, that affect cytoskeletal and membrane dynamics. We investigated the role of MARCKS (myristoylated, alanine-rich C-kinase substrate) in dendrites of 3-week-old hippocampal cultures. MARCKS associates with membranes via the combined action of myristoylati...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.08.027
更新日期:2005-10-06 00:00:00
abstract::Advances in defining mechanisms of cortical development have been paralleled in recent years by an intense interest in translating these findings into greater insight of both childhood- and adult-onset cognitive and mental health disorders of developmental etiology. Successful integration of basic and clinical finding...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.04.015
更新日期:2005-05-05 00:00:00
abstract::People are embedded in social interaction that shapes their brains throughout lifetime. Instead of emerging from lower-level cognitive functions, social interaction could be the default mode via which humans communicate with their environment. Should this hypothesis be true, it would have profound implications on how ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2015.09.022
更新日期:2015-10-07 00:00:00
abstract::Long-term memory and synaptic plasticity are thought to require the synthesis of new proteins at activated synapses. The CPEB family of RNA binding proteins, including Drosophila Orb2, has been implicated in this process. The precise mechanism by which these molecules regulate memory formation is however poorly unders...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.08.028
更新日期:2012-10-18 00:00:00
abstract::Previous studies of the ferret visual cortex indicate that the development of direction selectivity requires visual experience. Here, we used two-photon calcium imaging to study the development of direction selectivity in layer 2/3 neurons of the mouse visual cortex in vivo. Surprisingly, just after eye opening nearly...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.06.013
更新日期:2011-08-11 00:00:00
abstract::Conditioned place preference (CPP) is a widely used model of addiction-related behavior whose underlying mechanisms are not understood. In this study, we used dual site silicon probe recordings in freely moving mice to examine interactions between the hippocampus and nucleus accumbens in cocaine CPP. We found that CPP...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.04.015
更新日期:2018-06-06 00:00:00
abstract::Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.06.004
更新日期:2014-06-18 00:00:00
abstract::In this issue of Neuron, Stepanyants et al. embark on quantitative analyses of the axonal and dendritic arbors of cortical neurons. They test whether the paths taken by axons actually bring them closer to their true synaptic partners than they would have gotten by chance encounters based on the same axon trajectories....
journal_title:Neuron
pub_type: 评论
doi:10.1016/j.neuron.2004.07.006
更新日期:2004-07-22 00:00:00
abstract::Autism spectrum disorder (ASD) may arise from increased ratio of excitatory to inhibitory neurotransmission in the brain. Many pharmacological treatments have been tested in ASD, but only limited success has been achieved. Here we report that BTBR T(+)Itpr3(tf)/J (BTBR) mice, a model of idiopathic autism, have reduced...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.01.016
更新日期:2014-03-19 00:00:00
abstract::Each residue in and flanking the M2 membrane-spanning segment of the alpha subunit, from Glu-241 to Glu-262, was mutated to cysteine, and the mutant subunits were expressed together with wild-type beta, gamma, and delta subunits in Xenopus oocytes. Cysteines substituted for Glu-262, Leu-258, Val-255, Ser-252, Leu-251,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90257-7
更新日期:1994-10-01 00:00:00
abstract::Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and climbing fiber EPSCs for tens of seconds. This depolarization-induced suppression of excitation (DSE) is accompanied by altered paired-pulse plasticity, suggesting a presynaptic locus. Fluorometric imaging revealed that postsynap...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00246-x
更新日期:2001-03-01 00:00:00
abstract::For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ...
journal_title:Neuron
pub_type:
doi:10.1016/j.neuron.2009.09.038
更新日期:2009-10-15 00:00:00
abstract::The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RI...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2005.06.002
更新日期:2005-06-16 00:00:00
abstract::In this issue of Neuron, Fossati et al. (2016) report that through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory and inhibitory synapse development, offering a putative evolutionary genetic mechanism for preserving excitatory/inhibitory balance during speciation. ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2016.07.008
更新日期:2016-07-20 00:00:00
abstract::Targeted therapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal pathways. Receptors relevant to CNS disorders typically have associated proteins discretely expressed in specific neuronal pathways; these accessory proteins provide a new dimension for drug discovery. Recent studie...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.10.001
更新日期:2017-12-06 00:00:00
abstract::The hippocampal CA2 subregion has a different anatomical connectivity pattern within the entorhino-hippocampal circuit than either the CA1 or CA3 subregion. Yet major differences in the neuronal activity patterns of CA2 compared with the other CA subregions have not been reported. We show that standard spatial and tem...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.12.001
更新日期:2015-01-07 00:00:00
abstract::Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...
journal_title:Neuron
pub_type: 临床试验,杂志文章
doi:10.1016/s0896-6273(01)00199-4
更新日期:2001-01-01 00:00:00
abstract::Two critical amino acids in the visual pigment rhodopsin are Lys-296, the site of attachment of retinal to the protein through a protonated Schiff base linkage, and Glu-113, the Schiff base counterion. Mutation of Lys-296 or Glu-113 results in constitutive activation of opsin, as assayed by its ability to activate tra...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90034-b
更新日期:1992-10-01 00:00:00
abstract::Olfactory receptor neurons (ORNs) are replaced and differentiate in adult animals, but differentiation in dissociated cell culture has not been demonstrated. To test whether contact with the CNS regulates maturation, neonatal rat olfactory cells were grown on a culture substrate or on CNS astrocytes. Mature ORNs, immu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90139-5
更新日期:1992-06-01 00:00:00
abstract::The slow (<1 Hz) rhythm is a defining feature of the electroencephalogram during sleep. Since cortical circuits can generate this rhythm in isolation, it is assumed that the accompanying slow oscillation in thalamocortical (TC) neurons is largely a passive reflection of neocortical activity. Here we show, however, tha...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00623-2
更新日期:2002-03-14 00:00:00
abstract::We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90152-x
更新日期:1994-01-01 00:00:00
abstract::LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and abnormalities in hippocampal dendritic spine structure. The findings ar...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(02)00759-6
更新日期:2002-07-03 00:00:00
abstract::Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00200-9
更新日期:2003-05-08 00:00:00
abstract::Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.09.029
更新日期:2006-11-22 00:00:00
abstract::Recent studies have shown that hippocampal "time cells" code for sequential moments in temporally organized experiences. However, it is currently unknown whether these temporal firing patterns critically rely on upstream cortical input. Here we employ an optogenetic approach to explore the effect of large-scale inacti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.04.003
更新日期:2017-05-03 00:00:00
abstract::A neural network can sustain and switch between different activity patterns to execute multiple behaviors. By monitoring the decision making for directional locomotion through motor circuit calcium imaging in behaving Caenorhabditis elegans (C. elegans), we reveal that C. elegans determines the directionality of movem...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.09.005
更新日期:2011-11-17 00:00:00
abstract::How does the noradrenergic nucleus locus coeruleus act on target networks to regulate behavior? In this issue of Neuron, Zerbi et al. (2019) combine functional neuroimaging and pharmacogenetics in mice to tackle that question, uncovering a network action underlying stress. And providing insight for cognition? ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.07.033
更新日期:2019-08-21 00:00:00