Abstract:
:People are embedded in social interaction that shapes their brains throughout lifetime. Instead of emerging from lower-level cognitive functions, social interaction could be the default mode via which humans communicate with their environment. Should this hypothesis be true, it would have profound implications on how we think about brain functions and how we dissect and simulate them. We suggest that the research on the brain basis of social cognition and interaction should move from passive spectator science to studies including engaged participants and simultaneous recordings from the brains of the interacting persons.
journal_name
Neuronjournal_title
Neuronauthors
Hari R,Henriksson L,Malinen S,Parkkonen Ldoi
10.1016/j.neuron.2015.09.022subject
Has Abstractpub_date
2015-10-07 00:00:00pages
181-93issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00779-5journal_volume
88pub_type
杂志文章,评审相关文献
NEURON文献大全abstract::In rodents, each main olfactory bulb contains two mirror-symmetric glomerular maps, a feature not found in the initial topographic maps of other sensory systems. Targeting tracer injections to identified glomeruli revealed that isofunctional odor columns-translaminar assemblies connected to a given glomerulus-were spe...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00194-6
更新日期:2003-04-24 00:00:00
abstract::Phosphorylation of brain Na+ channels by protein kinase C (PKC) decreases peak Na+ current and slows macroscopic inactivation, but receptor-activated modulation of Na+ currents via the PKC pathway has not been demonstrated. We have examined modulation of Na+ channels by activation of muscarinic receptors in acutely-is...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80125-7
更新日期:1996-05-01 00:00:00
abstract::Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In contrast to these animal models, most human narcolepsy is not familial, is discordant in identical twins, and has not been linked to mutations of the Hcrt system. Thus, the cause of human narc...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00058-1
更新日期:2000-09-01 00:00:00
abstract::GABAergic, somatostatin-containing bitufted interneurons in layer 2/3 of rat neocortex are excited via glutamatergic excitatory postsynaptic potentials (EPSPs) by pyramidal neurons located in the same cortical layer. Pair recordings showed that short bursts of backpropagating dendritic action potentials (APs) reduced ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81044-2
更新日期:1999-12-01 00:00:00
abstract::Spinal cord axons display a rostrocaudal, positional bias in their innervation of sympathetic ganglia and intercostal skeletal muscles. In an effort to examine the molecular basis of this positional specificity, we used the cyclophosphamide immunosuppression method to produce monoclonal antibodies that bind preferenti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90081-p
更新日期:1990-10-01 00:00:00
abstract::Circadian clock proteins are modified in many different ways. The best-studied posttranslational modification is phosphorylation, with well-known kinases and phosphatases regulating the function and stability of clock proteins. Degradation of these proteins usually involves ubiquitylation or sumoylation, and some of t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.12.018
更新日期:2008-01-10 00:00:00
abstract::The brain basis of language, music, and emotion can be studied from the perspective of the psychological and cognitive sciences. Does this approach link to concerns of the humanities meaningfully? We outline prospects of developing a genuine neurohumanities research program. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.10.021
更新日期:2020-11-25 00:00:00
abstract::The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00236-7
更新日期:2001-03-01 00:00:00
abstract::Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.06.004
更新日期:2014-06-18 00:00:00
abstract::Loss-of-function mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are the major cause of early-onset Parkinson's disease (PD). In this issue of Neuron, Kalia et al. show that the bcl-2-associated athanogene 5 (BAG5) enhances dopamine neuron death in an in vivo model of PD through inhibiting the E3 l...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2004.12.007
更新日期:2004-12-16 00:00:00
abstract::Social environment modulates learning through unknown mechanisms. Here, we report that a pheromone mixture that signals overcrowding inhibits C. elegans from learning to avoid pathogenic bacteria. We find that learning depends on the balanced signaling of two insulin-like peptides (ILPs), INS-16 and INS-4, which act r...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.09.006
更新日期:2019-12-18 00:00:00
abstract::Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem ce...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2015.01.026
更新日期:2015-04-22 00:00:00
abstract::Promises are one of the oldest human-specific psychological mechanisms fostering cooperation and trust. Here, we study the neural underpinnings of promise keeping and promise breaking. Subjects first make a promise decision (promise stage), then they anticipate whether the promise affects the interaction partner's dec...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.11.017
更新日期:2009-12-10 00:00:00
abstract::The link between dysregulated serotonergic activity and depression and anxiety disorders is well established, yet the molecular mechanisms underlying these psychopathologies are not fully understood. Here, we explore the role of microRNAs in regulating serotonergic (5HT) neuron activity. To this end, we determined the...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.05.042
更新日期:2014-07-16 00:00:00
abstract::During development, newly born neurons migrate away from their initial birth sites to their final positions in the mature brain. The neurotrophin BDNF has been shown to regulate the migration of granule cells in the cerebellum. The cellular mechanisms that mediate this chemotactic response have not been resolved. In t...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2007.06.025
更新日期:2007-07-05 00:00:00
abstract::The idea that memory is stored in the brain as physical alterations goes back at least as far as Plato, but further conceptualization of this idea had to wait until the 20(th) century when two guiding theories were presented: the "engram theory" of Richard Semon and Donald Hebb's "synaptic plasticity theory." While a ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2015.08.002
更新日期:2015-09-02 00:00:00
abstract::A neural network can sustain and switch between different activity patterns to execute multiple behaviors. By monitoring the decision making for directional locomotion through motor circuit calcium imaging in behaving Caenorhabditis elegans (C. elegans), we reveal that C. elegans determines the directionality of movem...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.09.005
更新日期:2011-11-17 00:00:00
abstract::How a single fertilized cell generates diverse neuronal populations has been a fundamental biological problem since the 19(th) century. Classical histological methods revealed that postmitotic neurons are produced in a precise temporal and spatial order from germinal cells lining the cerebral ventricles. In the 20(th)...
journal_title:Neuron
pub_type: 历史文章,杂志文章
doi:10.1016/j.neuron.2011.05.005
更新日期:2011-05-26 00:00:00
abstract::The subunit stoichiometry of the mammalian K+ channel KV1.1 (RCK1) was examined by linking together the coding sequences of 2-5 K+ channel subunits in a single open reading frame and tagging the expression of individual subunits with a mutation (Y379K or Y379R) that altered the sensitivity of the channel to block by e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90239-a
更新日期:1992-11-01 00:00:00
abstract::Learning can be characterized as the extraction of reliable predictions about stimulus occurrences from past experience. In two experiments, we investigated the interval of temporal integration of previous learning trials in different brain regions using implicit and explicit Pavlovian fear conditioning with a dynamic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.06.008
更新日期:2005-07-21 00:00:00
abstract::While nerve growth factor (NGF) is best known for its trophic functions, recent experiments indicate that it can also cause cell death during development by activating the neurotrophin receptor p75. We now identify microglial cells as the source of NGF as a killing agent in the developing eye. When the retina is separ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80432-8
更新日期:1998-01-01 00:00:00
abstract::G protein-coupled receptors (GPCRs) mediate diverse signaling processes, including olfaction. G protein-coupled receptor kinases (GRKs) are important regulators of G protein signal transduction that specifically phosphorylate activated GPCRs to terminate signaling. Despite previously described roles for GRKs in GPCR s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00252-1
更新日期:2004-05-27 00:00:00
abstract::Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review evidence from mouse knockout studies demonstrating the normal functions of autophagy as a protective factor against neurodegeneration associated with...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.01.022
更新日期:2017-03-08 00:00:00
abstract::Synaptic clustering of neurotransmitter receptors is crucial for efficient signal transduction and integration in neurons. PDZ domain-containing proteins such as PSD-95/SAP90 interact with the intracellular C termini of a variety of receptors and are thought to be important in the targeting and anchoring of receptors ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80689-3
更新日期:1999-01-01 00:00:00
abstract::Cognitive control is subjectively costly, suggesting that engagement is modulated in relationship to incentive state. Dopamine appears to play key roles. In particular, dopamine may mediate cognitive effort by two broad classes of functions: (1) modulating the functional parameters of working memory circuits subservin...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2015.12.029
更新日期:2016-02-17 00:00:00
abstract::Although Caenorhabditis elegans has been utilized extensively to study synapse formation and function, relatively little is known about synaptic plasticity in C. elegans. We show that a brief treatment with the cholinesterase inhibitor aldicarb induces a form of presynaptic potentiation whereby ACh release at neuromus...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.04.021
更新日期:2011-07-14 00:00:00
abstract::Carbon monoxide (CO) induces a long-lasting alteration in cerebellar alpha 3-Na,K-ATPase independent of [Na+] but linked to cGMP synthesis and localized to Purkinje neurons. The action of CO is absent in Purkinje neuron-deficient mice, mimicked by 8-Br-cGMP, and blocked by inhibition of PKG. Glutamate (Glu) and metabo...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90222-8
更新日期:1995-04-01 00:00:00
abstract::Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.07.037
更新日期:2013-09-18 00:00:00
abstract::The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of b...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00368-4
更新日期:2003-07-03 00:00:00
abstract::The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Car...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.03.017
更新日期:2016-05-04 00:00:00