Abstract：
:Loss-of-function mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are the major cause of early-onset Parkinson's disease (PD). In this issue of Neuron, Kalia et al. show that the bcl-2-associated athanogene 5 (BAG5) enhances dopamine neuron death in an in vivo model of PD through inhibiting the E3 ligase activity of parkin and the chaperone activity of Hsp70.
journal_name
Neuronjournal_title
Neuronauthors
Chung KK,Dawson TMdoi
10.1016/j.neuron.2004.12.007subject
Has Abstractpub_date
2004-12-16 00:00:00pages
899-901issue
6eissn
0896-6273issn
1097-4199pii
S0896627304007986journal_volume
44pub_type
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