Abstract：
:The Drosophila Dscams are immunoglobulin superfamily members produced from a single gene that is diversified by alternative splicing to produce a family of cell-surface proteins with over 19,000 different ectodomain isoforms. Dscams are critical for neuronal wiring, and mounting evidence suggests that they play a key role in self-avoidance between sister branches from neurons, which depends on homophilic self-recognition by Dscams. Two recent papers shed new light on Dscam recognition: first by showing that the vast majority of Dscam isoforms mediate specific homophilic binding and second by revealing the essence of the molecular basis of homophilic recognition by Dscams through high-resolution structural studies.
journal_name
Neuronjournal_title
Neuronauthors
Shapiro Ldoi
10.1016/j.neuron.2007.09.024subject
Has Abstractpub_date
2007-10-04 00:00:00pages
10-3issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(07)00722-2journal_volume
56pub_type
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