cDNA clones coding for the structural subunit of a chicken brain nicotinic acetylcholine receptor.

Abstract:

:Nicotinic acetylcholine receptors (AChRs) immunoaffinity-purified from brains are composed of only two kinds of subunits rather than the four kinds present in muscle-type AChRs. Here we report the N-terminal protein sequences of the structural subunits of AChRs from rat and chicken brains and the cloning of full-length cDNAs for the chicken brain AChR structural subunit. Previously, the N-terminal amino acid sequence of the ACh-binding subunit of AChR immunoaffinity-purified from rat brain was shown to correspond to the cDNA alpha 4. Thus, cDNA sequences are now known for both of the subunits that form one AChR subtype in vivo.

journal_name

Neuron

journal_title

Neuron

authors

Schoepfer R,Whiting P,Esch F,Blacher R,Shimasaki S,Lindstrom J

doi

10.1016/0896-6273(88)90145-6

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

241-8

issue

3

eissn

0896-6273

issn

1097-4199

pii

0896-6273(88)90145-6

journal_volume

1

pub_type

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