Abstract:
:Nicotinic acetylcholine receptors (AChRs) immunoaffinity-purified from brains are composed of only two kinds of subunits rather than the four kinds present in muscle-type AChRs. Here we report the N-terminal protein sequences of the structural subunits of AChRs from rat and chicken brains and the cloning of full-length cDNAs for the chicken brain AChR structural subunit. Previously, the N-terminal amino acid sequence of the ACh-binding subunit of AChR immunoaffinity-purified from rat brain was shown to correspond to the cDNA alpha 4. Thus, cDNA sequences are now known for both of the subunits that form one AChR subtype in vivo.
journal_name
Neuronjournal_title
Neuronauthors
Schoepfer R,Whiting P,Esch F,Blacher R,Shimasaki S,Lindstrom Jdoi
10.1016/0896-6273(88)90145-6subject
Has Abstractpub_date
1988-05-01 00:00:00pages
241-8issue
3eissn
0896-6273issn
1097-4199pii
0896-6273(88)90145-6journal_volume
1pub_type
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