Abstract:
:Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a novel protein, GRAB (guanine nucleotide exchange factor for Rab3A), which interacts with both InsP6K1 and Rab3A, a Ras-like GTPase that regulates synaptic vesicle exocytosis. GRAB is a physiologic GEF (guanine nucleotide exchange factor) for Rab3A. Consistent with a role of Rab3A in synaptic vesicle exocytosis, GRAB regulates depolarization-induced release of dopamine from PC12 cells and nicotinic agonist-induced hGH release from bovine adrenal chromaffin cells. The association of InsP6K1 with GRAB fits with a role for InsP7 in vesicle exocytosis.
journal_name
Neuronjournal_title
Neuronauthors
Luo HR,Saiardi A,Nagata E,Ye K,Yu H,Jung TS,Luo X,Jain S,Sawa A,Snyder SHdoi
10.1016/s0896-6273(01)00384-1subject
Has Abstractpub_date
2001-08-16 00:00:00pages
439-51issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(01)00384-1journal_volume
31pub_type
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