Abstract：
:Homeostatic regulation of energy balance in rodents changes dramatically during the first 3 postnatal weeks. Neuropeptide Y (NPY) and melanocortin neurons in the arcuate nucleus, a primary energy homeostatic center in adults, do not fully innervate the paraventricular nucleus (PVN) until the third postnatal week. We have identified two classes of PVN neurons responsive to these neuropeptides, tonically firing neurosecretory (NS) and burst-firing preautonomic (PA) cells. In neonates, NPY could inhibit GABAergic inputs to nearly all NS and PA neurons, while melanocortin regulation was minimal. However, there was a dramatic, age-dependent decrease in NPY responses specifically in the PA neurons, and a 3-fold increase in melanocortin responses in NS cells. These age-dependent changes were accompanied by changes in spontaneous GABAergic currents onto these neurons. This primarily NPYergic regulation in the neonates likely promotes the positive energy balance necessary for growth, while the developmental switch correlates with maturation of homeostatic regulation of energy balance.
journal_name
Neuronjournal_title
Neuronauthors
Melnick I,Pronchuk N,Cowley MA,Grove KL,Colmers WFdoi
10.1016/j.neuron.2007.10.034subject
Has Abstractpub_date
2007-12-20 00:00:00pages
1103-15issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(07)00830-6journal_volume
56pub_type
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