Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness.

Abstract:

:The panoply of cognitive, affective, motivational, and social functions that underpin everyday human experience requires precisely choreographed patterns of interaction between networked brain regions. Perhaps not surprisingly, diverse forms of psychopathology are characterized by breakdowns in these interregional relationships. Here, we discuss how functional brain imaging has provided insights into the nature of brain dysconnectivity in mental illness. Synthesizing work to date, we propose that genetic and environmental risk factors impinge upon systems-level circuits for several core dimensions of cognition, producing transdiagnostic symptoms. We argue that risk-associated disruption of these circuits mediates susceptibility to broad domains of psychopathology rather than discrete disorders.

journal_name

Neuron

journal_title

Neuron

authors

Buckholtz JW,Meyer-Lindenberg A

doi

10.1016/j.neuron.2012.06.002

subject

Has Abstract

pub_date

2012-06-21 00:00:00

pages

990-1004

issue

6

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(12)00514-4

journal_volume

74

pub_type

杂志文章,评审

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