Abstract：
:Declarative memories are thought to be stored within anatomically distributed neuronal networks requiring the hippocampus; however, it is unclear how neocortical areas participate in memory at the time of encoding. Here, we use a c-fos-based genetic tagging system to selectively express the channelrhodopsin variant, ChEF, and optogenetically reactivate a specific neural ensemble in retrosplenial cortex (RSC) engaged by context fear conditioning. Artificial stimulation of RSC was sufficient to produce both context-specific behavior and downstream cellular activity commensurate with natural experience. Moreover, optogenetically but not contextually elicited responses were insensitive to hippocampal inactivation, suggesting that although the hippocampus is needed to coordinate activation by sensory cues, a higher-order cortical framework can independently subserve learned behavior, even shortly after learning.
journal_name
Neuronjournal_title
Neuronauthors
Cowansage KK,Shuman T,Dillingham BC,Chang A,Golshani P,Mayford Mdoi
10.1016/j.neuron.2014.09.022subject
Has Abstractpub_date
2014-10-22 00:00:00pages
432-41issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(14)00842-3journal_volume
84pub_type
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