Abstract:
:The slow (<1 Hz) rhythm is a defining feature of the electroencephalogram during sleep. Since cortical circuits can generate this rhythm in isolation, it is assumed that the accompanying slow oscillation in thalamocortical (TC) neurons is largely a passive reflection of neocortical activity. Here we show, however, that by activating the metabotropic glutamate receptor (mGluR), mGluR1a, cortical inputs can recruit intricate cellular mechanisms that enable the generation of an intrinsic slow oscillation in TC neurons in vitro with identical properties to those observed in vivo. These mechanisms rely on the "window" component of the T-type Ca(2+) current and a Ca(2+)-activated, nonselective cation current. These results suggest an active role for the thalamus in shaping the slow (<1 Hz) sleep rhythm.
journal_name
Neuronjournal_title
Neuronauthors
Hughes SW,Cope DW,Blethyn KL,Crunelli Vdoi
10.1016/s0896-6273(02)00623-2subject
Has Abstractpub_date
2002-03-14 00:00:00pages
947-58issue
6eissn
0896-6273issn
1097-4199pii
S0896627302006232journal_volume
33pub_type
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