Abstract:
:The presynaptic function of myosin II was studied at cholinergic synapses formed between rat superior cervical ganglion neurons in culture. Immunofluorescent staining showed that myosin II was colocalized with synaptophysin at the presynaptic nerve terminals. Antimyosin II antibody introduced into presynaptic neurons inhibited synaptic transmission. Transmission was also inhibited in a dose-dependent manner by two inhibitors of myosin light chain kinase: a peptide, SM-1, and an organic inhibitor, wortmannin. The inhibition produced by these agents was dependent on presynaptic activity. Extracellularly applied wortmannin also blocked synaptic transmission, but its effects were slower in onset. Wortmannin also decreased postsynaptic potentials and post-tetanic potentiation in intact superior cervical ganglia. These results suggest a model in which myosin light chain kinase phosphorylates myosin, and the resultant change in actin-myosin interactions is involved in neurotransmitter release.
journal_name
Neuronjournal_title
Neuronauthors
Mochida S,Kobayashi H,Matsuda Y,Yuda Y,Muramoto K,Nonomura Ydoi
10.1016/0896-6273(94)90051-5subject
Has Abstractpub_date
1994-11-01 00:00:00pages
1131-42issue
5eissn
0896-6273issn
1097-4199pii
0896-6273(94)90051-5journal_volume
13pub_type
杂志文章相关文献
NEURON文献大全abstract::Brain function relies on specificity of synaptic connectivity patterns among different classes of neurons. Yet, the substrates of specificity in complex neuropil remain largely unknown. We search for imprints of specificity in the layout of axonal and dendritic arbors from the rat neocortex. An analysis of 3D reconstr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.06.013
更新日期:2004-07-22 00:00:00
abstract::The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for information processing in neural circuits. However, little is known about the spatial principles of E and I synaptic organization across the entire dendritic tree of mammalian neurons. We developed a new open-source reconstr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.02.015
更新日期:2020-05-20 00:00:00
abstract::Propagation in higher animals requires the efficient and accurate display of innate mating behaviors. In Drosophila melanogaster, male courtship consists of a stereotypic sequence of behaviors involving multiple sensory modalities, such as vision, audition, and chemosensation. For example, taste bristles located in th...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00542-7
更新日期:2003-09-11 00:00:00
abstract::Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion i...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2011.10.001
更新日期:2011-10-20 00:00:00
abstract::In this issue of Neuron, Ambrozkiewicz et al. (2018) define a new molecular circuit controlling neuronal polarization and migration through the transcription factor SOX9 to coordinate the production of regulators of both protein synthesis and degradation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.11.022
更新日期:2018-12-05 00:00:00
abstract::Perceptual decisions require the transformation of raw sensory inputs into cortical representations suitable for stimulus discrimination. One of the best-known examples of this transformation involves the middle temporal area (MT) of the primate visual cortex. Area MT provides a robust representation of stimulus motio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.06.024
更新日期:2017-07-19 00:00:00
abstract::Painful mechanical stimuli activate multiple peripheral sensory afferent subtypes simultaneously, including nociceptors and low-threshold mechanoreceptors (LTMRs). Using an optogenetic approach, we demonstrate that LTMRs do not solely serve as touch receptors but also play an important role in acute pain signaling. We...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.11.027
更新日期:2017-01-04 00:00:00
abstract::The calcium-activated small conductance potassium channel SK3 plays an essential role in the regulation of dopamine neuron activity patterns. Here we demonstrate that expression of a human disease-related SK3 mutation (hSK3Δ) in dopamine neurons of mice disrupts the balance between tonic and phasic dopamine neuron act...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.07.044
更新日期:2013-11-20 00:00:00
abstract::In this issue of Neuron, Katsuki and colleagues show that cell-autonomous mechanisms divide Drosophila axons into proximal and distal compartments. Axon guidance receptors selectively localize to one compartment. A diffusion barrier exists near the compartment boundary, suggesting that it may have properties like thos...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.10.011
更新日期:2009-10-29 00:00:00
abstract::A multitude of synaptic proteins interact at the active zones of nerve terminals to achieve the high temporal precision of neurotransmitter release in synchrony with action potentials. Though synaptotagmin has been recognized as the Ca2+ sensor for synchronous release, it may have additional roles of action. We addres...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.07.028
更新日期:2009-08-27 00:00:00
abstract::NMDA receptor subunit composition varies throughout the brain, providing molecular diversity in NMDA receptor function. The NR2 subunits (NR2A-D) in large part dictate the distinct functional properties of NMDA receptors and differentially regulate receptor trafficking. Although the NR2C subunit is highly enriched in ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.04.015
更新日期:2009-05-28 00:00:00
abstract::Brandon et al. (2014) show that the formation of place cell representations in new environments is preserved under septal inactivation, and is thus likely independent of the hippocampal theta rhythm and, by implication, the firing of entorhinal grid cells and the process of path integration. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.05.011
更新日期:2014-05-21 00:00:00
abstract::Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal networks. This dysfunction emerges during early development, before a detectable behavioral readout, yet the cellular elements controlling the abnormal maturation are still unknown. Here, we address this open question by...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.09.042
更新日期:2020-01-08 00:00:00
abstract::As different classes of sensory neurons project into the CNS, their axons segregate and establish distinct trajectories and target zones. One striking instance of axonal segregation is the projection of sensory neurons into the spinal cord, where proprioceptive axons avoid the superficial dorsal horn-the target zone o...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.10.032
更新日期:2006-12-07 00:00:00
abstract::S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group on the target protein. Under physiological conditions, S-nitrosylation can be an important modulator of signal transduction pathways,...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2013.05.005
更新日期:2013-05-22 00:00:00
abstract::Does our understanding of the human brain remain incomplete without a proper understanding of how the brain processes music? Here, the author makes a passionate plea for the use of music in the investigation of human emotion and its brain correlates, arguing that music can change activity in all brain structures assoc...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.04.029
更新日期:2018-06-27 00:00:00
abstract::Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knockout shows a neocortica...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.04.036
更新日期:2014-06-18 00:00:00
abstract::Reversible silencing of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal excitation, for which the majority of studies have used a limited number of optogenetic and chemogenetic tools, the number of genetically...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.06.050
更新日期:2017-08-02 00:00:00
abstract::mRNA coding for brain-derived neurotrophic factor (BDNF) has been detected in cultured L929 fibroblasts, rat dermal fibroblasts, and sciatic nerve Schwann cells, as well as in rat skin. Medium conditioned by cultured fibroblasts and Schwann cells also stimulates neurite growth from retinal explants and promotes the su...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90265-2
更新日期:1991-08-01 00:00:00
abstract::Synaptic plasticity during critical periods of development requires intact inhibitory circuitry. We report that subplate neurons are needed both for maturation of inhibition and for the proper sign of ocular dominance (OD) plasticity. Removal of subplate neurons prevents the developmental upregulation of genes involve...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.07.008
更新日期:2006-09-07 00:00:00
abstract::The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked m...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(02)00910-8
更新日期:2002-09-12 00:00:00
abstract::The amplitudes and kinetics of miniature excitatory synaptic currents (MESCs) in mammalian central neurons vary widely. It is unclear whether this variability occurs at each synapse or arises from differences among a heterogeneous population of synapses. Furthermore, it is not known how variability in these currents w...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90073-x
更新日期:1995-07-01 00:00:00
abstract::To investigate the role of the pathogenic prion protein (PrP(Sc)) in controlling susceptibility to foreign prions, two Syrian hamster (SHa) prion strains, Sc237 and DY, were transmitted to transgenic mice expressing chimeric SHa/mouse PrP genes, Tg(MH2M). First passage of SHa(Sc237) prions exhibited prolonged incubati...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00726-2
更新日期:2002-06-13 00:00:00
abstract::Spontaneous fMRI fluctuations are organized in large-scale spatiotemporal structures, or resting-state networks (RSN). However, it is unknown how task performance affects RSN dynamics. We use MEG to measure slow (∼0.1 Hz) coherent fluctuations of band-limited power (BLP), a robust correlate of RSN, during rest and mov...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.06.022
更新日期:2013-08-21 00:00:00
abstract::Two studies in this issue of Neuron challenge widely held assumptions about the role of positive feedback in recurrent neuronal networks. Goldman shows that such feedback is not necessary for memory maintenance in a neural integrator, and Murphy and Miller show that it is not necessary for amplification of orientation...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.02.006
更新日期:2009-02-26 00:00:00
abstract::Dopamine (DA) transmission mediates numerous aspects of behavior. Although DA release is strongly linked to firing of DA neurons, recent developments indicate the importance of presynaptic modulation at striatal dopaminergic terminals. The endocannabinoid (eCB) system regulates DA release and is a canonical gatekeeper...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.11.012
更新日期:2017-12-06 00:00:00
abstract::We show that serotonin inhibits synaptic transmission at C. elegans neuromuscular junctions, and we describe a signaling pathway that mediates this effect. Release of acetylcholine from motor neurons was assayed by measuring the sensitivity of intact animals to the acetylcholinesterase inhibitor aldicarb. By this assa...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80835-1
更新日期:1999-09-01 00:00:00
abstract::The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hip...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.02.028
更新日期:2005-04-07 00:00:00
abstract::As a means to automate the three-dimensional histological analysis of brain tissue, we demonstrate the use of femtosecond laser pulses to iteratively cut and image fixed as well as fresh tissue. Cuts are accomplished with 1 to 10 microJ pulses to ablate tissue with micron precision. We show that the permeability, immu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00370-2
更新日期:2003-07-03 00:00:00
abstract::Based on extrapolation from excitatory synapses, it is often assumed that depletion of the releasable pool of synaptic vesicles is the main factor underlying depression at inhibitory synapses. In this issue of Neuron, using subcellular patch-clamp recording from inhibitory presynaptic terminals, Kawaguchi and Sakaba (...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.03.006
更新日期:2015-03-18 00:00:00