Disruption of dopamine neuron activity pattern regulation through selective expression of a human KCNN3 mutation.

abstract：:We investigated the contribution of the inferior temporal (IT) cortical neurons to the active maintenance of internal representations. The activity of single neurons in the IT cortex was recorded while the monkeys performed a sequential-type associative memory task in which distractor stimuli interrupted the delay epo...

journal_title：Neuron

authors： Takeda M,Naya Y,Fujimichi R,Takeuchi D,Miyashita Y

更新日期：2005-12-08 00:00:00

abstract：:NMDA receptor subunit composition varies throughout the brain, providing molecular diversity in NMDA receptor function. The NR2 subunits (NR2A-D) in large part dictate the distinct functional properties of NMDA receptors and differentially regulate receptor trafficking. Although the NR2C subunit is highly enriched in ...

journal_title：Neuron

authors： Chen BS,Roche KW

更新日期：2009-05-28 00:00:00

abstract：:During normal vision, the focus of gaze continually jumps from one important image feature to the next. In this issue of Neuron, Mazer and Gallant analyze neural activity in higher-level visual cortex during this kind of active visual exploration, and they demonstrate a localized enhancement of visual responses that p...

journal_title：Neuron

authors： Connor CE

更新日期：2003-12-18 00:00:00

abstract：:To investigate the role of the entorhinal cortex in memory at a molecular level, we developed transgenic mice in which transgene expression was inducible and limited to the superficial layers of the medial entorhinal cortex, pre- and parasubiculum. We found that expression of a constitutively active mutant form of CaM...

journal_title：Neuron

authors： Yasuda M,Mayford MR

更新日期：2006-04-20 00:00:00

abstract：:Here we describe the properties of a synapse in the Drosophila antennal lobe and show how they can explain certain sensory computations in this brain region. The synapse between olfactory receptor neurons (ORNs) and projection neurons (PNs) is very strong, reflecting a large number of release sites and high release pr...

journal_title：Neuron

authors： Kazama H,Wilson RI

更新日期：2008-05-08 00:00:00

abstract：:A study by Zhang et al. in this issue of Neuron reveals a novel mechanism of control of vestibular motor functions by the orexin (hypocretin) system in the perifornical/LH area through the lateral vestibular nucleus in the brainstem. This knowledge provides new insights into the understanding of brain circuitry that c...

journal_title：Neuron

authors： Gao XB,Horvath TL

更新日期：2011-02-24 00:00:00

abstract：:To investigate the role of the pathogenic prion protein (PrP(Sc)) in controlling susceptibility to foreign prions, two Syrian hamster (SHa) prion strains, Sc237 and DY, were transmitted to transgenic mice expressing chimeric SHa/mouse PrP genes, Tg(MH2M). First passage of SHa(Sc237) prions exhibited prolonged incubati...

journal_title：Neuron

authors： Peretz D,Williamson RA,Legname G,Matsunaga Y,Vergara J,Burton DR,DeArmond SJ,Prusiner SB,Scott MR

更新日期：2002-06-13 00:00:00

abstract：:Immunophilins, including FK506-binding proteins (FKBPs), are protein chaperones with peptidyl-prolyl isomerase (PPIase) activity. Initially identified as pharmacological receptors for immunosuppressants to regulate immune responses via isomerase-independent mechanisms, FKBPs are most highly expressed in the nervous sy...

journal_title：Neuron

authors： Shim S,Yuan JP,Kim JY,Zeng W,Huang G,Milshteyn A,Kern D,Muallem S,Ming GL,Worley PF

更新日期：2009-11-25 00:00:00

abstract：:Brain function relies on specificity of synaptic connectivity patterns among different classes of neurons. Yet, the substrates of specificity in complex neuropil remain largely unknown. We search for imprints of specificity in the layout of axonal and dendritic arbors from the rat neocortex. An analysis of 3D reconstr...

journal_title：Neuron

authors： Stepanyants A,Tamás G,Chklovskii DB

更新日期：2004-07-22 00:00:00

abstract：:Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct G(beta)gamma modulation of Ca2+ channels, a slower Galpha(q/11)-mediated mechanism has remaine...

journal_title：Neuron

authors： Delmas P,Coste B,Gamper N,Shapiro MS

更新日期：2005-07-21 00:00:00

abstract：:We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...

journal_title：Neuron

authors： Maconochie DJ,Zempel JM,Steinbach JH

更新日期：1994-01-01 00:00:00

abstract：:Sonic hedgehog (Shh) is a putative morphogen secreted by the floor plate and notochord, which specifies the fate of multiple cell types in the ventral aspect of the vertebrate nervous system. Since in Drosophila the actions of Hh have been shown to be transduced by Cubitus interruptus (Ci), a zinc finger transcription...

journal_title：Neuron

authors： Hynes M,Stone DM,Dowd M,Pitts-Meek S,Goddard A,Gurney A,Rosenthal A

更新日期：1997-07-01 00:00:00

abstract：:GABAergic, somatostatin-containing bitufted interneurons in layer 2/3 of rat neocortex are excited via glutamatergic excitatory postsynaptic potentials (EPSPs) by pyramidal neurons located in the same cortical layer. Pair recordings showed that short bursts of backpropagating dendritic action potentials (APs) reduced ...

journal_title：Neuron

authors： Zilberter Y,Kaiser KM,Sakmann B

更新日期：1999-12-01 00:00:00

abstract：:cGMP has long been suspected to play a role in synaptic plasticity, but the inaccessibility of nerve terminals to electrical recording has impeded tests of this hypothesis. In posterior pituitary nerve terminals, nitric oxide enhanced Ca(2+)-activated K+ channel activity by activating guanylate cyclase and PKG. This e...

journal_title：Neuron

authors： Klyachko VA,Ahern GP,Jackson MB

更新日期：2001-09-27 00:00:00

abstract：:Although substantial advances have been made in behavioral and pharmacological treatments for addictions, moving treatment development to the next stage may require novel ways of approaching addictions, particularly ways based on new findings regarding the neurobiological underpinnings of addictions that also assimila...

journal_title：Neuron

authors： Potenza MN,Sofuoglu M,Carroll KM,Rounsaville BJ

更新日期：2011-02-24 00:00:00

abstract：:Accurate motion detection requires neural circuitry that compensates for global visual field motion. Select subtypes of retinal ganglion cells perceive image motion and connect to the accessory optic system (AOS) in the brain, which generates compensatory eye movements that stabilize images during slow visual field mo...

journal_title：Neuron

authors： Sun LO,Brady CM,Cahill H,Al-Khindi T,Sakuta H,Dhande OS,Noda M,Huberman AD,Nathans J,Kolodkin AL

更新日期：2015-05-20 00:00:00

abstract：:Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) report in Nature that primates evolved novel transcriptional responses to neuronal activity, including induction of musclin/osteocrin (OSTN), which may regulate specialized aspects of prim...

journal_title：Neuron

authors： Pollen AA,Kriegstein AR

更新日期：2016-11-23 00:00:00

abstract：:Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holorece...

journal_title：Neuron

authors： Wang Q,Chiu SL,Koropouli E,Hong I,Mitchell S,Easwaran TP,Hamilton NR,Gustina AS,Zhu Q,Ginty DD,Huganir RL,Kolodkin AL

更新日期：2017-12-06 00:00:00

abstract：:Autism spectrum disorder (ASD) may arise from increased ratio of excitatory to inhibitory neurotransmission in the brain. Many pharmacological treatments have been tested in ASD, but only limited success has been achieved. Here we report that BTBR T(+)Itpr3(tf)/J (BTBR) mice, a model of idiopathic autism, have reduced...

journal_title：Neuron

authors： Han S,Tai C,Jones CJ,Scheuer T,Catterall WA

更新日期：2014-03-19 00:00:00

abstract：:In this issue of Neuron, Vyazovskiy et al. reports on progressive changes in cortical unit activity within extended wakefulness and within extended sleep paralleling changes in EEG slow-wave sleep activity. Sleep debt may be integrated at the level of individual cortical neurons, providing support for the synaptic hom...

journal_title：Neuron

authors： Mignot E,Huguenard JR

更新日期：2009-09-24 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamica...

journal_title：Neuron

authors： Zolles G,Wenzel D,Bildl W,Schulte U,Hofmann A,Müller CS,Thumfart JO,Vlachos A,Deller T,Pfeifer A,Fleischmann BK,Roeper J,Fakler B,Klöcker N

更新日期：2009-06-25 00:00:00

abstract：:Mapping of the chromosomal location of genes essential for sweet and bitter taste and identification of the relevant G protein-coupled receptors reveals unanticipated complexity in taste signaling pathways. The distribution of sweet and bitter receptors suggests complete cellular segregation of these taste modalities....

journal_title：Neuron

authors： Lewcock JW,Reed RR

更新日期：2001-08-30 00:00:00

abstract：:A neuron-specific cytoskeletal antigen (5E10), whose expression pattern during initial motoneuron outgrowth into the chick limb suggests that it is playing a role in axon guidance, is described. This antigen, which was shown to be a phosphorylated epitope, probably of the intermediate weight neurofilament protein (NF-...

journal_title：Neuron

authors： Landmesser L,Swain S

更新日期：1992-02-01 00:00:00

abstract：:Action potentials initiate in the axon initial segment (AIS), a specialized compartment enriched with Na(+) and K(+) channels. Recently, we found that T- and R-type Ca(2+) channels are concentrated in the AIS, where they contribute to local subthreshold membrane depolarization and thereby influence action potential in...

journal_title：Neuron

authors： Bender KJ,Ford CP,Trussell LO

更新日期：2010-11-04 00:00:00

abstract：:The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studies attempting to elucidate the underlying mechanism for this increased risk, how apoE4 influences AD onset and progression has yet to be proven. However, prevailing evide...

journal_title：Neuron

authors： Kim J,Basak JM,Holtzman DM

更新日期：2009-08-13 00:00:00

abstract：:The activation of light-dependent K+ channels in ciliary photoreceptors from Pecten was investigated using intracellular dialysis of putative messengers and modulators. Neither elevated [Ca2+] nor BAPTA changed the membrane current in the dark or the light response. IP3 and the antagonists heparin and decavanadate wer...

journal_title：Neuron

authors： del Pilar Gomez M,Nasi E

更新日期：1995-09-01 00:00:00

abstract：:By using a tau construct with two mimicked acetylation sites as identified in AD brains, Tracy et al. (2016) found that acetylated tau promotes synaptic dysfunction through disruption of postsynaptic KIBRA signaling pathways, actin dynamics, and AMPA receptor trafficking. ...

journal_title：Neuron

authors： Hettinger JC,Cirrito JR

更新日期：2016-04-20 00:00:00

abstract：:Activity is known to be important for the refinement of neural connections in the developing brain. In this issue of Neuron, Hanson and Landmesser provide evidence that GABA-dependent spontaneous bursting of motor neurons in the embryonic spinal cord is required for the correct execution of an early axon pathfinding d...

journal_title：Neuron

authors： Goulding M

更新日期：2004-09-02 00:00:00

abstract：:Precise apposition of presynaptic and postsynaptic domains is a fundamental property of all neuronal circuits. Experiments in vitro suggest that Neuroligins and Neurexins function as key regulatory proteins in this process. In a genetic screen, we recovered several mutant alleles of Drosophila neuroligin 1 (dnlg1) tha...

journal_title：Neuron

authors： Banovic D,Khorramshahi O,Owald D,Wichmann C,Riedt T,Fouquet W,Tian R,Sigrist SJ,Aberle H

更新日期：2010-06-10 00:00:00

abstract：:The neocortex of mammals is composed of cortical fields that have a unique organization associated with the animal's ecological niche and lifestyle. Each cortical field has a specific pattern of connections with other cortical fields and brain structures, and together they comprise a neocortical network that generates...

journal_title：Neuron

authors： Krubitzer L

更新日期：2007-10-25 00:00:00