Abstract:
:We show that serotonin inhibits synaptic transmission at C. elegans neuromuscular junctions, and we describe a signaling pathway that mediates this effect. Release of acetylcholine from motor neurons was assayed by measuring the sensitivity of intact animals to the acetylcholinesterase inhibitor aldicarb. By this assay, exogenous serotonin inhibited acetylcholine release, whereas serotonin antagonists stimulated release. The effects of serotonin on synaptic transmission were mediated by GOA-1 (a Galpha0 subunit) and DGK-1 (a diacylglycerol [DAG] kinase), both of which act in the ventral cord motor neurons. Mutants lacking goa-1 G(alpha)0 accumulated abnormally high levels of the DAG-binding protein UNC-13 at motor neuron nerve terminals, suggesting that serotonin inhibits synaptic transmission by decreasing the abundance of UNC-13 at release sites.
journal_name
Neuronjournal_title
Neuronauthors
Nurrish S,Ségalat L,Kaplan JMdoi
10.1016/s0896-6273(00)80835-1subject
Has Abstractpub_date
1999-09-01 00:00:00pages
231-42issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80835-1journal_volume
24pub_type
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