Abstract:
:Elevation of cerebral Mg2+ with a novel orally delivered ionophore, magnesium threonate, enhances cognition in young and old rats over a 12-24 day treatment interval, as outlined in a paper by Slutsky et al. in this issue of Neuron. Despite both Mg2+ and Zn2+ blocking the NMDA receptor channel, sustained extracellular Mg2+ elevation mimics sustained synaptic Zn2+ concentrations by increasing hippocampal NR2B expression and bouton density.
journal_name
Neuronjournal_title
Neuronauthors
Bush AIdoi
10.1016/j.neuron.2010.01.015subject
Has Abstractpub_date
2010-01-28 00:00:00pages
143-4issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(10)00034-6journal_volume
65pub_type
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