Structural basis of the different gating kinetics of fetal and adult acetylcholine receptors.

abstract：:We show here that antisense MAP2 oligonucleotides inhibit neurite outgrowth in cultured cerebellar macroneurons. Unlike control neurons, which first extend a lamellipodial veil followed by a consolidation phase during which the cells extend minor neurites, MAP2-suppressed cells persist with lamellipodia and later beco...

journal_title：Neuron

authors： Caceres A,Mautino J,Kosik KS

更新日期：1992-10-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) is a potent regulator of oligodendrocyte development and myelination in vitro, but its effect on myelination in vivo has never been tested directly. Therefore, we examined brain growth and myelination in a transgenic mouse line that overexpresses IGF-I. By postnatal day 55, when br...

journal_title：Neuron

authors： Carson MJ,Behringer RR,Brinster RL,McMorris FA

更新日期：1993-04-01 00:00:00

abstract：:Terminal Schwann cells overlying the neuromuscular junction sprout elaborate processes upon muscle denervation. We show here that motor axons use these processes as guides/substrates during regeneration; in so doing, they escape the confines of endplates and grow between endplates to generate polyneuronal innervation....

journal_title：Neuron

authors： Son YJ,Thompson WJ

更新日期：1995-01-01 00:00:00

abstract：:Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGluR-dependent LTD. The increase in Arc/Arg3.1 translation requires e...

journal_title：Neuron

authors： Park S,Park JM,Kim S,Kim JA,Shepherd JD,Smith-Hicks CL,Chowdhury S,Kaufmann W,Kuhl D,Ryazanov AG,Huganir RL,Linden DJ,Worley PF

更新日期：2008-07-10 00:00:00

abstract：:When faced with a crowded visual scene, observers must selectively attend to behaviorally relevant objects to avoid sensory overload. Often this selection process is guided by prior knowledge of a target-defining feature (e.g., the color red when looking for an apple), which enhances the firing rate of visual neurons ...

journal_title：Neuron

authors： Serences JT,Boynton GM

更新日期：2007-07-19 00:00:00

abstract：:Voluntary spatial attention concentrates neural resources at the attended location. Here, we examined the effects of spatial attention on spatial position selectivity in humans. We measured population receptive fields (pRFs) using high-field functional MRI (fMRI) (7T) while subjects performed an attention-demanding ta...

journal_title：Neuron

authors： Klein BP,Harvey BM,Dumoulin SO

更新日期：2014-10-01 00:00:00

abstract：:Alzheimer's disease is characterized by the deposition of senile plaques and progressive dementia. The molecular mechanisms that couple plaque deposition to neural system failure, however, are unknown. Using transgenic mouse models of AD together with multiphoton imaging, we measured neuronal calcium in individual neu...

journal_title：Neuron

authors： Kuchibhotla KV,Goldman ST,Lattarulo CR,Wu HY,Hyman BT,Bacskai BJ

更新日期：2008-07-31 00:00:00

abstract：:To investigate the role of the pathogenic prion protein (PrP(Sc)) in controlling susceptibility to foreign prions, two Syrian hamster (SHa) prion strains, Sc237 and DY, were transmitted to transgenic mice expressing chimeric SHa/mouse PrP genes, Tg(MH2M). First passage of SHa(Sc237) prions exhibited prolonged incubati...

journal_title：Neuron

authors： Peretz D,Williamson RA,Legname G,Matsunaga Y,Vergara J,Burton DR,DeArmond SJ,Prusiner SB,Scott MR

更新日期：2002-06-13 00:00:00

abstract：:Oscillatory activity in the basolateral amygdala (BLA) is critical for emotional behavior. In this issue of Neuron, Stujenske et al. (2014) describe novel dynamics of BLA theta-gamma-coupled neuronal oscillations associated with conditioned and innate fear. ...

journal_title：Neuron

authors： Bocchio M,Capogna M

更新日期：2014-08-20 00:00:00

abstract：:A key function of the nucleus accumbens is to promote vigorous reward seeking, but the corresponding neural mechanism has not been identified despite many years of research. Here, we study cued flexible approach behavior, a form of reward seeking that strongly depends on the accumbens, and we describe a robust, single...

journal_title：Neuron

authors： McGinty VB,Lardeux S,Taha SA,Kim JJ,Nicola SM

更新日期：2013-06-05 00:00:00

abstract：:Carbon monoxide (CO) induces a long-lasting alteration in cerebellar alpha 3-Na,K-ATPase independent of [Na+] but linked to cGMP synthesis and localized to Purkinje neurons. The action of CO is absent in Purkinje neuron-deficient mice, mimicked by 8-Br-cGMP, and blocked by inhibition of PKG. Glutamate (Glu) and metabo...

journal_title：Neuron

authors： Nathanson JA,Scavone C,Scanlon C,McKee M

更新日期：1995-04-01 00:00:00

abstract：:The dopaminergic D3 receptor (D3R) is emerging as an antagonist of sensitized behavior induced by addictive drugs such as cocaine. New work by Wang and coworkers in this issue of Neuron now identifies CaMKII as an important negative regulator of the D3R. CaMKII relieves the D3R-mediated inhibition on sensitized behavi...

journal_title：Neuron

authors： Hell JW

更新日期：2009-02-12 00:00:00

abstract：:Degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive dysfunction in Alzheimer's disease (AD) and Down's syndrome (DS). We used Ts65Dn and Ts1Cje mouse models of DS to show that the increased dose of the amyloid precursor protein gene, App, acts to markedly decrease NGF retrograde transp...

journal_title：Neuron

authors： Salehi A,Delcroix JD,Belichenko PV,Zhan K,Wu C,Valletta JS,Takimoto-Kimura R,Kleschevnikov AM,Sambamurti K,Chung PP,Xia W,Villar A,Campbell WA,Kulnane LS,Nixon RA,Lamb BT,Epstein CJ,Stokin GB,Goldstein LS,Mobley WC

更新日期：2006-07-06 00:00:00

abstract：:Huntington's disease-like-2 (HDL2) is a phenocopy of Huntington's disease caused by CTG/CAG repeat expansion at the Junctophilin-3 (JPH3) locus. The mechanisms underlying HDL2 pathogenesis remain unclear. Here we developed a BAC transgenic mouse model of HDL2 (BAC-HDL2) that exhibits progressive motor deficits, select...

journal_title：Neuron

authors： Wilburn B,Rudnicki DD,Zhao J,Weitz TM,Cheng Y,Gu X,Greiner E,Park CS,Wang N,Sopher BL,La Spada AR,Osmand A,Margolis RL,Sun YE,Yang XW

更新日期：2011-05-12 00:00:00

abstract：:Glucose-inhibited neurons orchestrate behavior and metabolism according to body energy levels, but how glucose inhibits these cells is unknown. We studied glucose inhibition of orexin/hypocretin neurons, which promote wakefulness (their loss causes narcolepsy) and also regulate metabolism and reward. Here we demonstra...

journal_title：Neuron

authors： Burdakov D,Jensen LT,Alexopoulos H,Williams RH,Fearon IM,O'Kelly I,Gerasimenko O,Fugger L,Verkhratsky A

更新日期：2006-06-01 00:00:00

abstract：:Social group dynamics are highly complex. In this issue of Neuron, Anpilov et al. use a novel wireless optogenetic device to demonstrate that the repeated stimulation of oxytocin neurons modulates pro-social and agonistic behaviors in a time- and context-dependent manner. ...

journal_title：Neuron

authors： Maltese F,Papaleo F

更新日期：2020-08-19 00:00:00

abstract：:RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...

journal_title：Neuron

authors： Nussbacher JK,Tabet R,Yeo GW,Lagier-Tourenne C

更新日期：2019-04-17 00:00:00

abstract：:Accurate perception of the actions and intentions of other people is essential for successful interactions in a social environment. Several cortical areas that support this process respond selectively in fMRI to static and dynamic displays of human bodies and faces. Here we apply pattern-analysis techniques to arrive ...

journal_title：Neuron

authors： Peelen MV,Wiggett AJ,Downing PE

更新日期：2006-03-16 00:00:00

abstract：:Imaging large-scale circuit dynamics is crucial to understanding brain function, but most techniques have a limited depth of field. Here, we describe volumetric functional ultrasound imaging (vfUSI), a platform for brain-wide vfUSI of hemodynamic activity in awake head-fixed mice. We combined a high-frequency 1,024-ch...

journal_title：Neuron

authors： Brunner C,Grillet M,Sans-Dublanc A,Farrow K,Lambert T,Macé E,Montaldo G,Urban A

更新日期：2020-12-09 00:00:00

abstract：:We have devised a simple bioassay for the identification of molecules that inhibit growth cone motility. Chick dorsal root ganglion (DRG) growth cones extending on laminin collapse when exposed to a suspension of embryonic brain membranes. Detergent-solubilized membranes from which the detergent has been removed colla...

journal_title：Neuron

authors： Raper JA,Kapfhammer JP

更新日期：1990-01-01 00:00:00

abstract：:Homomeric assembly of Kir5.1, an inward-rectifying K+ channel subunit, is believed to be nonfunctional, although the subunit exists abundantly in the brain. We show that HEK293T cells cotransfected with Kir5.1 and PSD-95 exhibit a Ba(2+)-sensitive inward-rectifying K+ current. Kir5.1 coexpressed with PSD-95 located on...

journal_title：Neuron

authors： Tanemoto M,Fujita A,Higashi K,Kurachi Y

更新日期：2002-04-25 00:00:00

abstract：:The forebrain is one of most complex cellular structures known. Two phenomena that enable this complexity are tangential migrations that mix neurons from distinct progenitor fields, and axon guidance across intervening, noninnervated fields. A new paper in Cell by López-Bendito et al. has discovered the convergence of...

journal_title：Neuron

authors： Maroof AM,Anderson SA

更新日期：2006-04-20 00:00:00

abstract：:FLRTs are broadly expressed proteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors. How these functions direct cell behavior and the molecular mechanisms involved remain largely unclear. Here we use X-ray crystallography to revea...

journal_title：Neuron

authors： Seiradake E,del Toro D,Nagel D,Cop F,Härtl R,Ruff T,Seyit-Bremer G,Harlos K,Border EC,Acker-Palmer A,Jones EY,Klein R

更新日期：2014-10-22 00:00:00

abstract：:We used fear conditioning, which is known to alter synaptic efficacy in lateral amygdala (LA), to study molecular mechanisms underlying long-term memory. Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated with GRB2 in LA significantly more in conditioned than in control rat...

journal_title：Neuron

authors： Lamprecht R,Farb CR,LeDoux JE

更新日期：2002-11-14 00:00:00

abstract：:Molecular determinants of Ca2+ channel responsiveness to inhibition by receptor-coupled G proteins were investigated in Xenopus oocytes. The inhibitory response of alpha1B (N-type) channels was much larger than alpha1A (P/Q-type) channels, while alpha1C (L-type) channels were unresponsive. Differences in both degree a...

journal_title：Neuron

authors： Zhang JF,Ellinor PT,Aldrich RW,Tsien RW

更新日期：1996-11-01 00:00:00

abstract：:In this issue of Neuron,Lin et al. (2015) report an optical method to precisely manipulate the activity of GABAA receptors by designing a mutant receptor that binds photosensitive compounds. This allows for studying GABAA receptors in situ and represents a valuable tool to investigate how inhibition affects brain phys...

journal_title：Neuron

authors： Mortensen M,Smart TG

更新日期：2015-12-02 00:00:00

abstract：:We recently reported that homozygous Presenilin-1 (Psen1) knockin (KI) mice carrying the familial Alzheimer's disease (FAD) mutation L435F or C410Y recapitulate the phenotypes of Psen1(-/-) mice. Production and steady-state levels of Aβ40 and Aβ42 are undetectable in KI/KI brains and reduced in KI/+ brains, though the...

journal_title：Neuron

authors： Xia D,Kelleher RJ 3rd,Shen J

更新日期：2016-04-20 00:00:00

abstract：:Perceptual inference is biased by foreknowledge about what is probable or possible. How prior expectations are neurally represented during visual perception, however, remains unknown. We used functional magnetic resonance imaging to measure brain activity in humans judging simple visual stimuli. Perceptual decisions w...

journal_title：Neuron

authors： Summerfield C,Koechlin E

更新日期：2008-07-31 00:00:00

abstract：:It is widely believed that the brain performs approximate probabilistic inference to estimate causal variables in the world from ambiguous sensory data. To understand these computations, we need to analyze how information is represented and transformed by the actions of nonlinear recurrent neural networks. We propose ...

journal_title：Neuron

authors： Pitkow X,Angelaki DE

更新日期：2017-06-07 00:00:00

abstract：:In the brain, enormous numbers of neurons have functional individuality and distinct circuit specificities. Clustered Protocadherins (Pcdhs), diversified cell-surface proteins, are stochastically expressed by alternative promoter choice and affect dendritic arborization in individual neurons. Here we found that the Pc...

journal_title：Neuron

authors： Toyoda S,Kawaguchi M,Kobayashi T,Tarusawa E,Toyama T,Okano M,Oda M,Nakauchi H,Yoshimura Y,Sanbo M,Hirabayashi M,Hirayama T,Hirabayashi T,Yagi T

更新日期：2014-04-02 00:00:00