A Platform for Brain-wide Volumetric Functional Ultrasound Imaging and Analysis of Circuit Dynamics in Awake Mice.

abstract：:Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the...

journal_title：Neuron

authors： Lüscher C,Huber KM

更新日期：2010-02-25 00:00:00

abstract：:Experience is a powerful sculptor of developing neural connections. In the primary visual cortex (V1), cortical connections are particularly susceptible to the effects of sensory manipulation during a postnatal critical period. At the molecular level, this activity-dependent plasticity requires the transformation of s...

journal_title：Neuron

authors： Taha S,Hanover JL,Silva AJ,Stryker MP

更新日期：2002-10-24 00:00:00

abstract：:All sensory information is encoded in neural spike trains. It is unknown how the brain utilizes this neural code to drive behavior. Here, we unravel the decoding rules of the brain at the most elementary level by linking behavioral decisions to retinal output signals in a single-photon detection task. A transgenic mou...

journal_title：Neuron

authors： Smeds L,Takeshita D,Turunen T,Tiihonen J,Westö J,Martyniuk N,Seppänen A,Ala-Laurila P

更新日期：2019-11-06 00:00:00

abstract：:Visual experience before eye-opening is not usually thought to have any developmental significance. Here we show that naturalistic visual stimuli presented through unopened eyelids robustly activate neurons in the ferret dorsal lateral geniculate nucleus. Further, dark-rearing prior to natural eye-opening has striking...

journal_title：Neuron

authors： Akerman CJ,Smyth D,Thompson ID

更新日期：2002-12-05 00:00:00

abstract：:Grid cells, border cells, head-directions cells, and conjunctive correlates found in the Medial Entorhinal Cortex (MEC) indicate the presence of highly specialized neural circuits that process allocentric space. New technical advancements, as described by Tang et al. (2014) in this issue, offer an integrated approach ...

journal_title：Neuron

authors： Savelli F,Knierim JJ

更新日期：2014-12-17 00:00:00

abstract：:Convergent evidence suggests that corticostriatal interactions act as a gate to select the input to working memory (WM). However, not all information in WM is relevant for behavior simultaneously. For this reason, a second "output gate" might advantageously govern which contents of WM influence behavior. Here, we test...

journal_title：Neuron

authors： Chatham CH,Frank MJ,Badre D

更新日期：2014-02-19 00:00:00

abstract：:It is well established that the intraparietal sulcus (IPS) plays an important role in the processing and representation of numerical magnitude. Two recent studies by Piazza et al. and Cohen Kadosh et al. published in this issue of Neuron used fMRI adaptation to explore the extent to which parietal number processing is...

journal_title：Neuron

authors： Ansari D

更新日期：2007-01-18 00:00:00

abstract：:Genomic disorders are a group of human genetic diseases caused by genomic rearrangements resulting in copy-number variation (CNV) affecting a dosage-sensitive gene or genes critical for normal development or maintenance. These disorders represent a wide range of clinically distinct entities but include many diseases a...

journal_title：Neuron

authors： Lee JA,Lupski JR

更新日期：2006-10-05 00:00:00

abstract：:The Abl and Arg tyrosine kinases play fundamental roles in the development and function of the central nervous system. Arg is most abundant in adult mouse brain, especially in synapse-rich regions. arg(-/-) mice develop normally but exhibit multiple behavioral abnormalities, suggesting that arg(-/-) brains suffer from...

journal_title：Neuron

authors： Koleske AJ,Gifford AM,Scott ML,Nee M,Bronson RT,Miczek KA,Baltimore D

更新日期：1998-12-01 00:00:00

abstract：:Memory abilities differ greatly across individuals. To explore a source of these differences, we characterized the varied strategies people adopt during unconstrained encoding. Participants intentionally encoded object pairs during functional MRI. Principal components analysis applied to a strategy questionnaire revea...

journal_title：Neuron

authors： Kirchhoff BA,Buckner RL

更新日期：2006-07-20 00:00:00

abstract：:We developed a large-scale dynamical model of the macaque neocortex, which is based on recently acquired directed- and weighted-connectivity data from tract-tracing experiments, and which incorporates heterogeneity across areas. A hierarchy of timescales naturally emerges from this system: sensory areas show brief, tr...

journal_title：Neuron

authors： Chaudhuri R,Knoblauch K,Gariel MA,Kennedy H,Wang XJ

更新日期：2015-10-21 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor is important for synaptic plasticity and nervous system development and function. We have used genetic and electrophysiological methods to demonstrate that NMR-1, a Caenorhabditis elegans NMDA-type ionotropic glutamate receptor subunit, plays a role in the ...

journal_title：Neuron

authors： Brockie PJ,Mellem JE,Hills T,Madsen DM,Maricq AV

更新日期：2001-08-30 00:00:00

abstract：:Several subunits of the glutamate receptor of the AMPA subtype have been cloned recently. These subunits, named GluR1, GluR2, GluR3, and GluR4, exist as two splicing variants (flip and flop). We have determined the subset of AMPA receptor subunits expressed by single cerebellar Purkinje cells in culture. This was achi...

journal_title：Neuron

authors： Lambolez B,Audinat E,Bochet P,Crépel F,Rossier J

更新日期：1992-08-01 00:00:00

abstract：:Synaptic vesicles are tethered to the active zone where they are docked/primed so that they can fuse rapidly upon Ca(2+) influx. To directly study these steps at a CNS presynaptic terminal, we used total internal reflection fluorescence (TIRF) microscopy at the live isolated calyx of Held terminal and measured the mov...

journal_title：Neuron

authors： Midorikawa M,Sakaba T

更新日期：2015-11-04 00:00:00

abstract：:Dynamic rearrangements of axon terminal arbors may be critical for establishing appropriate connections in the developing nervous system. Here, the changes in complex retinal axon arbors in the tecta of live Xenopus larvae were followed during the formation of the topographic retinotectal projection. Three-dimensional...

journal_title：Neuron

authors： O'Rourke NA,Cline HT,Fraser SE

更新日期：1994-04-01 00:00:00

abstract：:Vertebrate rod and cone photoreceptors hyperpolarize when illuminated. However, synaptic input from horizontal cells can depolarize cones and even elicit action potentials. Using the whole-cell tight-seal recording technique, we determined that, in solitary cones isolated from a lizard retina, action potentials can be...

journal_title：Neuron

authors： Maricq AV,Korenbrot JI

更新日期：1988-08-01 00:00:00

abstract：:AMPA-type glutamate receptors (AMPARs) play a major role in excitatory synaptic transmission and plasticity. Channel properties are largely dictated by their composition of the four subunits, GluR1-4 (or A-D). Here we show that AMPAR assembly and subunit stoichiometry are determined by RNA editing in the pore loop. We...

journal_title：Neuron

authors： Greger IH,Khatri L,Kong X,Ziff EB

更新日期：2003-11-13 00:00:00

abstract：:The brain has often been described, quite accurately, as one of the most complex objects in the natural world. Understanding its workings, to say nothing about intervening in them, is among the hardest problems in science. While this makes the challenge all the more enticing, in the short term, it acts to limit the im...

journal_title：Neuron

authors： Sinha P

更新日期：2016-11-02 00:00:00

abstract：:Modification of AMPA receptor function is a major mechanism for the regulation of synaptic transmission and underlies several forms of synaptic plasticity. Post-translational palmitoylation is a reversible modification that regulates localization of many proteins. Here, we report that palmitoylation of the AMPA recept...

journal_title：Neuron

authors： Hayashi T,Rumbaugh G,Huganir RL

更新日期：2005-09-01 00:00:00

abstract：:Blood-feeding mosquitoes survive by feeding on nectar for metabolic energy but require a blood meal to develop eggs. Aedes aegypti females must accurately discriminate blood and nectar because each meal promotes mutually exclusive feeding programs with distinct sensory appendages, meal sizes, digestive tract targets, ...

journal_title：Neuron

authors： Jové V,Gong Z,Hol FJH,Zhao Z,Sorrells TR,Carroll TS,Prakash M,McBride CS,Vosshall LB

更新日期：2020-12-23 00:00:00

abstract：:Firing patterns of neurons in the orbitofrontal cortex (OF) were analyzed in rats trained to perform a task that encouraged incidental associations between distinct odors and the places where their occurrence was detected. Many of the neurons fired differentially when the animals were at a particular location or sampl...

journal_title：Neuron

authors： Lipton PA,Alvarez P,Eichenbaum H

更新日期：1999-02-01 00:00:00

abstract：:Accurate motion detection requires neural circuitry that compensates for global visual field motion. Select subtypes of retinal ganglion cells perceive image motion and connect to the accessory optic system (AOS) in the brain, which generates compensatory eye movements that stabilize images during slow visual field mo...

journal_title：Neuron

authors： Sun LO,Brady CM,Cahill H,Al-Khindi T,Sakuta H,Dhande OS,Noda M,Huberman AD,Nathans J,Kolodkin AL

更新日期：2015-05-20 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implicated in the biochemical ...

journal_title：Neuron

authors： Giasson BI,Lee VM

更新日期：2001-09-27 00:00:00

abstract：:Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiolog...

journal_title：Neuron

authors： Yoon KJ,Ming GL,Song H

更新日期：2018-07-25 00:00:00

abstract：:The time course and functional significance of the structural changes associated with long-term facilitation of Aplysia sensory to motor neuron synaptic connections in culture were examined by time-lapse confocal imaging of individual sensory neuron varicosities labeled with three different fluorescent markers: the wh...

journal_title：Neuron

authors： Kim JH,Udo H,Li HL,Youn TY,Chen M,Kandel ER,Bailey CH

更新日期：2003-09-25 00:00:00

abstract：:Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a chang...

journal_title：Neuron

authors： Vinck M,Batista-Brito R,Knoblich U,Cardin JA

更新日期：2015-05-06 00:00:00

abstract：:The structural basis for the synthesis of specific proteins within distinct intraneuronal compartments is unknown. We studied the distribution of poly(A) mRNA within cultured cerebrocortical neurons using high resolution in situ hybridization to identify cytoskeletal components that may anchor mRNA. After 1 day in cul...

journal_title：Neuron

authors： Bassell GJ,Singer RH,Kosik KS

更新日期：1994-03-01 00:00:00

abstract：:The tactile somatosensory pathway from whisker to cortex in rodents provides a well-defined system for exploring the link between molecular mechanisms, synaptic circuits, and behavior. The primary somatosensory cortex has an exquisite somatotopic map where each individual whisker is represented in a discrete anatomica...

journal_title：Neuron

authors： Petersen CC

更新日期：2007-10-25 00:00:00

abstract：:How does a visual search goal modulate the activity of neurons encoding different visual features (e.g., color, direction of motion)? Previous research suggests that goal-driven attention enhances the gain of neurons representing the target's visual features. Here, we present mathematical and behavioral evidence that ...

journal_title：Neuron

authors： Navalpakkam V,Itti L

更新日期：2007-02-15 00:00:00

abstract：:Much is known about the functions and properties of neuronal dendrites, but rarely has dendritic activation been monitored while the dendrite performs a computational task. In this issue of Neuron, Bollmann and Engert demonstrate that different regions of a dendrite in the tadpole optic tectum are tuned to stimuli in ...

journal_title：Neuron

authors： Waters J

更新日期：2009-03-26 00:00:00