Abstract：
:Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a change in arousal levels. We recorded single cells and local field potentials from area V1 in mice head-fixed on a running wheel and monitored pupil diameter to assay arousal. Using naturally occurring and induced state transitions, we dissociated arousal and locomotion effects in V1. Arousal suppressed spontaneous firing and strongly altered the temporal patterning of population activity. Moreover, heightened arousal increased the signal-to-noise ratio of visual responses and reduced noise correlations. In contrast, increased firing in anticipation of and during movement was attributable to locomotion effects. Our findings suggest complementary roles of arousal and locomotion in promoting functional flexibility in cortical circuits.
journal_name
Neuronjournal_title
Neuronauthors
Vinck M,Batista-Brito R,Knoblich U,Cardin JAdoi
10.1016/j.neuron.2015.03.028subject
Has Abstractpub_date
2015-05-06 00:00:00pages
740-54issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00252-4journal_volume
86pub_type
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