Abstract:
:Cortical motor areas are thought to contribute "higher-order processing," but what that processing might include is unknown. Previous studies of the smooth pursuit-related discharge of supplementary eye field (SEF) neurons have not distinguished activity associated with the preparation for pursuit from discharge related to processing or memory of the target motion signals. Using a memory-based task designed to separate these components, we show that the SEF contains signals coding retinal image-slip-velocity, memory, and assessment of visual motion direction, the decision of whether to pursue, and the preparation for pursuit eye movements. Bilateral muscimol injection into SEF resulted in directional errors in smooth pursuit, errors of whether to pursue, and impairment of initial correct eye movements. These results suggest an important role for the SEF in memory and assessment of visual motion direction and the programming of appropriate pursuit eye movements.
journal_name
Neuronjournal_title
Neuronauthors
Shichinohe N,Akao T,Kurkin S,Fukushima J,Kaneko CR,Fukushima Kdoi
10.1016/j.neuron.2009.05.010subject
Has Abstractpub_date
2009-06-11 00:00:00pages
717-32issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(09)00361-4journal_volume
62pub_type
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