Multiple calcium-dependent processes related to secretion in bovine chromaffin cells.

abstract：:Advancing psychiatry requires understanding brain malfunction at a microscopic scale, where neurons and synapses operate under constraints imposed by behavior, cognition, and neural architecture. Nonhuman primates are unmatched in approximating the structural and computational environment of the human brain. ...

journal_title：Neuron

authors： Heilbronner SR,Chafee MV

更新日期：2019-04-03 00:00:00

abstract：:Cortical synaptic circuitry develops rapidly in the second postnatal week, simultaneous with experience-dependent turnover of dendritic spines. To relate the emergence of sensory maps to synaptogenesis, we recorded synaptic potentials evoked by whisker deflection in layer 2/3 neurons from postnatal day (P) 12 to 20. A...

journal_title：Neuron

authors： Stern EA,Maravall M,Svoboda K

更新日期：2001-08-02 00:00:00

abstract：:GABAergic, somatostatin-containing bitufted interneurons in layer 2/3 of rat neocortex are excited via glutamatergic excitatory postsynaptic potentials (EPSPs) by pyramidal neurons located in the same cortical layer. Pair recordings showed that short bursts of backpropagating dendritic action potentials (APs) reduced ...

journal_title：Neuron

authors： Zilberter Y,Kaiser KM,Sakmann B

更新日期：1999-12-01 00:00:00

abstract：:During normal vision, the focus of gaze continually jumps from one important image feature to the next. In this issue of Neuron, Mazer and Gallant analyze neural activity in higher-level visual cortex during this kind of active visual exploration, and they demonstrate a localized enhancement of visual responses that p...

journal_title：Neuron

authors： Connor CE

更新日期：2003-12-18 00:00:00

abstract：:It has been hypothesized that the direction of synaptic weight change elicited by synaptic activity depends on the magnitude of the activity-dependent rise in intracellular Ca2+ concentration. Several aspects of this hypothesis were examined at the Schaffer collateral CA1 synapse, where both long-term depression (LTD)...

journal_title：Neuron

authors： Cummings JA,Mulkey RM,Nicoll RA,Malenka RC

更新日期：1996-04-01 00:00:00

abstract：:We present evidence that synapse retraction occurs during normal synaptic growth at the Drosophila neuromuscular junction (NMJ). An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex. Arp-1 dsRNA enhances synapse retrac...

journal_title：Neuron

authors： Eaton BA,Fetter RD,Davis GW

更新日期：2002-05-30 00:00:00

abstract：:Currents mediated by a glutamate transporter cloned from human motor cortex were measured in Xenopus oocytes. In the absence of glutamate, voltage jumps induced Na(+)-dependent capacitive currents that were blocked by kainate, a competitive transport antagonist. The pre-steady-state currents can be described by an ord...

journal_title：Neuron

authors： Wadiche JI,Arriza JL,Amara SG,Kavanaugh MP

更新日期：1995-05-01 00:00:00

abstract：:How primates perceive objects along with their detailed features remains a mystery. This ability to make fine visual discriminations depends upon a high-acuity analysis of spatial frequency (SF) along the visual hierarchy from V1 to inferotemporal cortex. By studying the transformation of SF across macaque parafoveal ...

journal_title：Neuron

authors： Lu Y,Yin J,Chen Z,Gong H,Liu Y,Qian L,Li X,Liu R,Andolina IM,Wang W

更新日期：2018-04-18 00:00:00

abstract：:In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...

journal_title：Neuron

authors： Grossmann T,Oberecker R,Koch SP,Friederici AD

更新日期：2010-03-25 00:00:00

abstract：:As different classes of sensory neurons project into the CNS, their axons segregate and establish distinct trajectories and target zones. One striking instance of axonal segregation is the projection of sensory neurons into the spinal cord, where proprioceptive axons avoid the superficial dorsal horn-the target zone o...

journal_title：Neuron

authors： Yoshida Y,Han B,Mendelsohn M,Jessell TM

更新日期：2006-12-07 00:00:00

abstract：:Functional neural circuit formation during development involves massive elimination of redundant synapses. In the cerebellum, one-to-one connection from excitatory climbing fiber (CF) to Purkinje cell (PC) is established by elimination of early-formed surplus CFs. This process depends on glutamatergic excitatory input...

journal_title：Neuron

authors： Nakayama H,Miyazaki T,Kitamura K,Hashimoto K,Yanagawa Y,Obata K,Sakimura K,Watanabe M,Kano M

更新日期：2012-04-26 00:00:00

abstract：:A neural network can sustain and switch between different activity patterns to execute multiple behaviors. By monitoring the decision making for directional locomotion through motor circuit calcium imaging in behaving Caenorhabditis elegans (C. elegans), we reveal that C. elegans determines the directionality of movem...

journal_title：Neuron

authors： Kawano T,Po MD,Gao S,Leung G,Ryu WS,Zhen M

更新日期：2011-11-17 00:00:00

abstract：:Innate defensive responses are essential for animal survival and are conserved across species. The ventral tegmental area (VTA) plays important roles in learned appetitive and aversive behaviors, but whether it plays a role in mediating or modulating innate defensive responses is currently unknown. We report that VTAG...

journal_title：Neuron

authors： Zhou Z,Liu X,Chen S,Zhang Z,Liu Y,Montardy Q,Tang Y,Wei P,Liu N,Li L,Song R,Lai J,He X,Chen C,Bi G,Feng G,Xu F,Wang L

更新日期：2019-08-07 00:00:00

abstract：:A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a key regulatory event in the "neural decision" to undergo these p...

journal_title：Neuron

authors： Hoeffer CA,Klann E

更新日期：2007-04-19 00:00:00

abstract：:We have purified and characterized a factor, from the conditioned medium of neural stem cell cultures, which is required for fibroblast growth factor 2's (FGF-2) mitogenic activity on neural stem cells. This autocrine/paracrine cofactor is a glycosylated form of cystatin C (CCg), whose N-glycosylation is required for ...

journal_title：Neuron

authors： Taupin P,Ray J,Fischer WH,Suhr ST,Hakansson K,Grubb A,Gage FH

更新日期：2000-11-01 00:00:00

abstract：:Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis. Inhibiting polyamine synthesis blocks the cAMP effect on regeneration. Eithe...

journal_title：Neuron

authors： Cai D,Deng K,Mellado W,Lee J,Ratan RR,Filbin MT

更新日期：2002-08-15 00:00:00

abstract：:The presynaptic function of myosin II was studied at cholinergic synapses formed between rat superior cervical ganglion neurons in culture. Immunofluorescent staining showed that myosin II was colocalized with synaptophysin at the presynaptic nerve terminals. Antimyosin II antibody introduced into presynaptic neurons ...

journal_title：Neuron

authors： Mochida S,Kobayashi H,Matsuda Y,Yuda Y,Muramoto K,Nonomura Y

更新日期：1994-11-01 00:00:00

abstract：:The subunit stoichiometry of the mammalian K+ channel KV1.1 (RCK1) was examined by linking together the coding sequences of 2-5 K+ channel subunits in a single open reading frame and tagging the expression of individual subunits with a mutation (Y379K or Y379R) that altered the sensitivity of the channel to block by e...

journal_title：Neuron

authors： Liman ER,Tytgat J,Hess P

更新日期：1992-11-01 00:00:00

abstract：:Membrane potential recordings in awake mice have correlated cortical state with locomotion and whisker movements. In this issue of Neuron, Reimer et al. (2014) now reveal that pupil dilation in stationary mice equally signals a change in cortical state and an enhancement of visual processing. ...

journal_title：Neuron

authors： Poulet JF

更新日期：2014-10-22 00:00:00

abstract：:The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the medial ganglionic eminence, the NKX2-1 transcription factor controls regional id...

journal_title：Neuron

authors： Sandberg M,Flandin P,Silberberg S,Su-Feher L,Price JD,Hu JS,Kim C,Visel A,Nord AS,Rubenstein JLR

更新日期：2016-09-21 00:00:00

abstract：:Intracortical somatosensory interfaces have now entered the clinical domain. Darie et al. explore the implications of research published in Science Translational Medicine by Flesher et al. (2016), discuss how to design such a system given current technology, and question how to effectively communicate with users about...

journal_title：Neuron

authors： Darie R,Powell M,Borton D

更新日期：2017-02-22 00:00:00

abstract：:The modulation of high voltage-activated (HVA) Ca2+ currents by L-glutamate and its agonists was investigated in cultured rat hypothalamic neurons. L-Glutamate and agonists selective for NMDA or non-NMDA receptors reversibly inhibited HVA Ca2+ currents. The putative presynaptic glutamate receptor agonist L-2-amino-4-p...

journal_title：Neuron

authors： Zeilhofer HU,Müller TH,Swandulla D

更新日期：1993-05-01 00:00:00

abstract：:Dopamine is thought to play a critical role in reinforcement learning and goal-directed behavior, but its function in action selection remains largely unknown. Here we demonstrate that nigrostriatal dopamine biases ongoing action selection. When mice were trained to dynamically switch the action selected at different ...

journal_title：Neuron

authors： Howard CD,Li H,Geddes CE,Jin X

更新日期：2017-03-22 00:00:00

abstract：:Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies. ...

journal_title：Neuron

authors： Hyman BT

更新日期：2014-06-18 00:00:00

abstract：:GABA(B) (gamma-aminobutyric acid type B) receptors are important for keeping neuronal excitability under control. Cloned GABA(B) receptors do not show the expected pharmacological diversity of native receptors and it is unknown whether they contribute to pre- as well as postsynaptic functions. Here, we demonstrate tha...

journal_title：Neuron

authors： Schuler V,Lüscher C,Blanchet C,Klix N,Sansig G,Klebs K,Schmutz M,Heid J,Gentry C,Urban L,Fox A,Spooren W,Jaton AL,Vigouret J,Pozza M,Kelly PH,Mosbacher J,Froestl W,Käslin E,Korn R,Bischoff S,Kaupmann K,van der

更新日期：2001-07-19 00:00:00

abstract：:The activation of light-dependent K+ channels in ciliary photoreceptors from Pecten was investigated using intracellular dialysis of putative messengers and modulators. Neither elevated [Ca2+] nor BAPTA changed the membrane current in the dark or the light response. IP3 and the antagonists heparin and decavanadate wer...

journal_title：Neuron

authors： del Pilar Gomez M,Nasi E

更新日期：1995-09-01 00:00:00

abstract：:Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission, induces synaptic plasticity, and coordinates firing of groups of neurons. As a result, it changes the state of neuronal networks throughout the brain and modifies their response to internal and external inputs: the classical rol...

journal_title：Neuron

authors： Picciotto MR,Higley MJ,Mineur YS

更新日期：2012-10-04 00:00:00

abstract：:The N-terminal 17 amino acids of huntingtin (NT17) can be phosphorylated on serines 13 and 16; however, the significance of these modifications in Huntington's disease pathogenesis remains unknown. In this study, we developed BAC transgenic mice expressing full-length mutant huntingtin (fl-mhtt) with serines 13 and 16...

journal_title：Neuron

authors： Gu X,Greiner ER,Mishra R,Kodali R,Osmand A,Finkbeiner S,Steffan JS,Thompson LM,Wetzel R,Yang XW

更新日期：2009-12-24 00:00:00

abstract：:Backpropagating action potentials (bAPs) are an important signal for associative synaptic plasticity in many neurons, but they often fail to fully invade distal dendrites. In this issue of Neuron, Sjöström and Häusser show that distal propagation failure leads to a spatial gradient of Hebbian plasticity in neocortical...

journal_title：Neuron

authors： Bender VA,Feldman DE

更新日期：2006-07-20 00:00:00

abstract：:During Drosophila visual system development, photoreceptor (R) axons choose their correct paths and targets in a step-wise fashion. R axons with different identities make specific pathfinding decisions at different stages during development. We show here that the transmembrane protein Golden goal (Gogo), which is dyna...

journal_title：Neuron

authors： Tomasi T,Hakeda-Suzuki S,Ohler S,Schleiffer A,Suzuki T

更新日期：2008-03-13 00:00:00