Overcoming Depression by Inhibition of Neural Burst Firing.

Abstract:

:The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression.

journal_name

Neuron

journal_title

Neuron

authors

Kim D,Cheong E,Shin HS

doi

10.1016/j.neuron.2018.05.032

subject

Has Abstract

pub_date

2018-06-06 00:00:00

pages

878-879

issue

5

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(18)30430-6

journal_volume

98

pub_type

杂志文章,评审

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