Abstract:
:Basal ganglia (BG) circuits orchestrate complex motor behaviors predominantly via inhibitory synaptic outputs. Although these inhibitory BG outputs are known to reduce the excitability of postsynaptic target neurons, precisely how this change impairs motor performance remains poorly understood. Here, we show that optogenetic photostimulation of inhibitory BG inputs from the globus pallidus induces a surge of action potentials in the ventrolateral thalamic (VL) neurons and muscle contractions during the post-inhibitory period. Reduction of the neuronal population with this post-inhibitory rebound firing by knockout of T-type Ca2+ channels or photoinhibition abolishes multiple motor responses induced by the inhibitory BG input. In a low dopamine state, the number of VL neurons showing post-inhibitory firing increases, while reducing the number of active VL neurons via photoinhibition of BG input, effectively prevents Parkinson disease (PD)-like motor symptoms. Thus, BG inhibitory input generates excitatory motor signals in the thalamus and, in excess, promotes PD-like motor abnormalities. VIDEO ABSTRACT.
journal_name
Neuronjournal_title
Neuronauthors
Kim J,Kim Y,Nakajima R,Shin A,Jeong M,Park AH,Jeong Y,Jo S,Yang S,Park H,Cho SH,Cho KH,Shim I,Chung JH,Paik SB,Augustine GJ,Kim Ddoi
10.1016/j.neuron.2017.08.028subject
Has Abstractpub_date
2017-08-30 00:00:00pages
1181-1196.e8issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30743-2journal_volume
95pub_type
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