Structure and assembly mechanism for heteromeric kainate receptors.

abstract：:The precise subunit composition of synaptic ionotropic receptors in the brain is poorly understood. This information is of particular importance with regard to AMPA-type glutamate receptors, the multimeric complexes assembled from GluA1-A4 subunits, as the trafficking of these receptors into and out of synapses is pro...

journal_title：Neuron

authors： Lu W,Shi Y,Jackson AC,Bjorgan K,During MJ,Sprengel R,Seeburg PH,Nicoll RA

更新日期：2009-04-30 00:00:00

abstract：:The vertebrate ventral midbrain contains 3-4 x 10(4) dopaminergic neurons that influence motor activity, emotional behavior, and cognition. Recently, glial cell line-derived neurotrophic factor (GDNF) was shown to be a potent survival factor for these dopaminergic neurons in culture. However, many midbrain dopaminergi...

journal_title：Neuron

authors： Poulsen KT,Armanini MP,Klein RD,Hynes MA,Phillips HS,Rosenthal A

更新日期：1994-11-01 00:00:00

abstract：:Neural synchronization plays an important role in information flow in the nervous system under healthy and pathological conditions. In this issue of Neuron, Gittis et al. show that reorganization of striatal microcircuits promotes synchronous activity and may underlie the pathological network oscillations at the root ...

journal_title：Neuron

authors： Belujon P,Grace AA

更新日期：2011-09-08 00:00:00

abstract：:The molecular specification of central circuits that coordinate expression of innate behaviors in response to specific sensory cues from the environment remains a puzzle. In this issue of Neuron, Choi, Dong, and colleagues used expression profiling and genetic axonal tracing to visualize a hypothalamic point of conver...

journal_title：Neuron

authors： Simerly R

更新日期：2005-05-19 00:00:00

abstract：:Identifying the spatial organization of tissues at cellular resolution from single-cell gene expression profiles is essential to understanding biological systems. Using an in situ 3D multiplexed imaging method, seqFISH, we identify unique transcriptional states by quantifying and clustering up to 249 genes in 16,958 c...

journal_title：Neuron

authors： Shah S,Lubeck E,Zhou W,Cai L

更新日期：2016-10-19 00:00:00

abstract：:Subiculum, the primary efferent pathway of hippocampus, participates in memory for spatial tasks, relapse to drug abuse, and temporal lobe seizures. Subicular pyramidal neurons exhibit low-threshold burst firing driven by a spike afterdepolarization. Here we report that burst firing can be regulated by stimulation of ...

journal_title：Neuron

authors： Moore SJ,Cooper DC,Spruston N

更新日期：2009-01-29 00:00:00

abstract：:The mechanisms generating precise connections between specific thalamic nuclei and cortical areas remain poorly understood. Using axon tracing analysis of ephrin/Eph mutant mice, we provide in vivo evidence that Eph receptors in the thalamus and ephrins in the cortex control intra-areal topographic mapping of thalamoc...

journal_title：Neuron

authors： Dufour A,Seibt J,Passante L,Depaepe V,Ciossek T,Frisén J,Kullander K,Flanagan JG,Polleux F,Vanderhaeghen P

更新日期：2003-07-31 00:00:00

abstract：:Light-evoked responses of all three major classes of retinal ganglion cells (RGCs) are mediated by NMDA receptors (NMDARs) and AMPA receptors (AMPARs). Although synaptic activity at RGC synapses is highly dynamic, synaptic plasticity has not been observed in adult RGCs. Here, using patch-clamp recordings in dark-adapt...

journal_title：Neuron

authors： Jones RS,Carroll RC,Nawy S

更新日期：2012-08-09 00:00:00

abstract：:Fibroblastic 3T3 and endocrine RIN cells were genetically modified by infection with a recombinant retrovirus encoding the form I of human tyrosine hydroxylase (TH) and selection in tyrosine-free medium. These cells were grafted to rats unilaterally lesioned with 6-hydroxy-dopamine. Both cell types survived implantati...

journal_title：Neuron

authors： Horellou P,Brundin P,Kalén P,Mallet J,Björklund A

更新日期：1990-10-01 00:00:00

abstract：:In response to changes in membrane potential, voltage-dependent ion channel proteins undergo conformational rearrangements that lead to channel opening. These rearrangements move a net charge, measured as "gating current", across the membrane. Here we characterize the effects of the pharmacological blocker 4-aminopyri...

journal_title：Neuron

authors： McCormack K,Joiner WJ,Heinemann SH

更新日期：1994-02-01 00:00:00

abstract：:The trigeminal loop in the brainstem comprises the innermost level of sensorimotor feedback in the rat vibrissa system. Anatomy suggests that this loop relays tactile information from the vibrissae to the motoneurons that control vibrissa movement. We demonstrate, using in vitro and in vivo recordings, that the trigem...

journal_title：Neuron

authors： Nguyen QT,Kleinfeld D

更新日期：2005-02-03 00:00:00

abstract：:Interactions between the hippocampus and prefrontal cortex (PFC) are critical for learning and memory. Hippocampal activity during awake sharp-wave ripple (SWR) events is important for spatial learning, and hippocampal SWR activity often represents past or potential future experiences. Whether or how this reactivation...

journal_title：Neuron

authors： Jadhav SP,Rothschild G,Roumis DK,Frank LM

更新日期：2016-04-06 00:00:00

abstract：:The biologically active photoproduct of rhodopsin, metarhodopsin II (M II), exists in a pH-sensitive equilibrium with its precursor, metarhodopsin I (M I). Increasing acidity favors M II, with the midpoint of the pH titration curve at pH 6.4. To test the long-standing proposal that histidine protonation regulates this...

journal_title：Neuron

authors： Weitz CJ,Nathans J

更新日期：1992-03-01 00:00:00

abstract：:Perceptual learning is a lifelong process. We begin by encoding information about the basic structure of the natural world and continue to assimilate information about specific patterns with which we become familiar. The specificity of the learning suggests that all areas of the cerebral cortex are plastic and can rep...

journal_title：Neuron

authors： Gilbert CD,Sigman M,Crist RE

更新日期：2001-09-13 00:00:00

abstract：:Neural circuits consist of highly precise connections among specific types of neurons that serve a common functional goal. How neurons distinguish among different synaptic targets to form functionally precise circuits remains largely unknown. Here, we show that during development, the adhesion molecule cadherin-6 (Cdh...

journal_title：Neuron

authors： Osterhout JA,Josten N,Yamada J,Pan F,Wu SW,Nguyen PL,Panagiotakos G,Inoue YU,Egusa SF,Volgyi B,Inoue T,Bloomfield SA,Barres BA,Berson DM,Feldheim DA,Huberman AD

更新日期：2011-08-25 00:00:00

abstract：:What underlies the large variation in mEPSC amplitude in the auditory system? And is this variability important? In this issue of Neuron, Li et al. (2014) address the significance of large mEPSCs to auditory processing and Chapochnikov et al. (2014) describe a novel mechanism underlying them. ...

journal_title：Neuron

authors： Lv C,Zenisek D

更新日期：2014-09-17 00:00:00

abstract：:Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with symptoms including social deficits, anxiety, and communication difficulties. However, ASD pathogenic mechanisms are poorly understood. Mutations of CUL3, which encodes Cullin 3 (CUL3), a component of an E3 ligase complex, are thought of a...

journal_title：Neuron

authors： Dong Z,Chen W,Chen C,Wang H,Cui W,Tan Z,Robinson H,Gao N,Luo B,Zhang L,Zhao K,Xiong WC,Mei L

更新日期：2020-02-05 00:00:00

abstract：:The N-terminal 17 amino acids of huntingtin (NT17) can be phosphorylated on serines 13 and 16; however, the significance of these modifications in Huntington's disease pathogenesis remains unknown. In this study, we developed BAC transgenic mice expressing full-length mutant huntingtin (fl-mhtt) with serines 13 and 16...

journal_title：Neuron

authors： Gu X,Greiner ER,Mishra R,Kodali R,Osmand A,Finkbeiner S,Steffan JS,Thompson LM,Wetzel R,Yang XW

更新日期：2009-12-24 00:00:00

abstract：:How do neurons develop, control, and maintain their electrical signaling properties in spite of ongoing protein turnover and perturbations to activity? From generic assumptions about the molecular biology underlying channel expression, we derive a simple model and show how it encodes an "activity set point" in single ...

journal_title：Neuron

authors： O'Leary T,Williams AH,Franci A,Marder E

更新日期：2014-05-21 00:00:00

abstract：:New technologies to probe the nervous system are propelling innovation and discovery at blinding speed, but are our trainees prepared to maximize this power? The growing role of engineering in research, such as materials, computing, electronics, and devices, compels us to rethink neuroscience education. Core technolog...

journal_title：Neuron

authors： Litt B

更新日期：2015-04-08 00:00:00

abstract：:Synapses have a limited pool of vesicles that are docked and primed for rapid release. In neuroendocrine cells, splice variants of the SNARE protein SNAP-25 and phosphorylation of SNAP-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate of vesicle depriming. Pre- and postt...

journal_title：Neuron

authors： Heidelberger R,Matthews G

更新日期：2004-02-05 00:00:00

abstract：:The brain has often been described, quite accurately, as one of the most complex objects in the natural world. Understanding its workings, to say nothing about intervening in them, is among the hardest problems in science. While this makes the challenge all the more enticing, in the short term, it acts to limit the im...

journal_title：Neuron

authors： Sinha P

更新日期：2016-11-02 00:00:00

abstract：:We developed a large-scale dynamical model of the macaque neocortex, which is based on recently acquired directed- and weighted-connectivity data from tract-tracing experiments, and which incorporates heterogeneity across areas. A hierarchy of timescales naturally emerges from this system: sensory areas show brief, tr...

journal_title：Neuron

authors： Chaudhuri R,Knoblauch K,Gariel MA,Kennedy H,Wang XJ

更新日期：2015-10-21 00:00:00

abstract：:The process by which neural circuitry in the brain plans and executes movements is not well understood. Until recently, most available data were limited either to single-neuron electrophysiological recordings or to measures of aggregate field or metabolism. Neither approach reveals how individual neurons' activities a...

journal_title：Neuron

authors： Afshar A,Santhanam G,Yu BM,Ryu SI,Sahani M,Shenoy KV

更新日期：2011-08-11 00:00:00

abstract：:The formation of topographic neural maps relies on the coordinate assignment of neuronal cell body position and axonal trajectory. The projection of motor neurons of the lateral motor column (LMC) along the dorsoventral axis of the limb mesenchyme constitutes a simple topographic map that is organized in a binary mann...

journal_title：Neuron

authors： Kania A,Jessell TM

更新日期：2003-05-22 00:00:00

abstract：:During Drosophila visual system development, photoreceptor (R) axons choose their correct paths and targets in a step-wise fashion. R axons with different identities make specific pathfinding decisions at different stages during development. We show here that the transmembrane protein Golden goal (Gogo), which is dyna...

journal_title：Neuron

authors： Tomasi T,Hakeda-Suzuki S,Ohler S,Schleiffer A,Suzuki T

更新日期：2008-03-13 00:00:00

abstract：:The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produc...

journal_title：Neuron

authors： Katz PS

更新日期：1996-02-01 00:00:00

abstract：:Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ ...

journal_title：Neuron

authors： Alcamo EA,Chirivella L,Dautzenberg M,Dobreva G,Fariñas I,Grosschedl R,McConnell SK

更新日期：2008-02-07 00:00:00

abstract：:In situ hybridization histochemistry reveals localized expression of the nicotinic acetylcholine receptor (nAChR) alpha 2 subunit mRNA restricted to the lateral spiriform nucleus (SpL) of the chick diencephalon. The alpha 2 nAChR transcripts are not detected in immature SpL neurons at 4.5-5 days of embryonic developme...

journal_title：Neuron

authors： Daubas P,Devillers-Thiéry A,Geoffroy B,Martinez S,Bessis A,Changeux JP

更新日期：1990-07-01 00:00:00

abstract：:The size of the movement and the molecular identity of the moving parts of the voltage sensor of a voltage-gated ion channel are debated. In the helical-screw model, the positively charged fourth transmembrane segment S4 slides and rotates along negative counter charges in S2 and S3, while in the paddle model, S4 carr...

journal_title：Neuron

authors： Broomand A,Elinder F

更新日期：2008-09-11 00:00:00