Engineering the next generation of brain scientists.

abstract：:Astrocytes metabolically interact with neighboring neurons by providing multiple substances to neurons. How astrocytes regulate neural functions via altering the neuronal metabolic state remains elusive. Here, we demonstrate that astrocytic ApoE vectors a variety of microRNAs (miRNAs), and these miRNAs specifically si...

journal_title：Neuron

authors： Li X,Zhang J,Li D,He C,He K,Xue T,Wan L,Zhang C,Liu Q

更新日期：2021-01-21 00:00:00

abstract：:Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits. ...

journal_title：Neuron

authors： Udeochu J,Sayed FA,Gan L

更新日期：2018-03-07 00:00:00

abstract：:Each odorant receptor gene defines a unique type of olfactory receptor neuron (ORN) and a corresponding type of second-order neuron. Because each odor can activate multiple ORN types, information must ultimately be integrated across these processing channels to form a unified percept. Here, we show that, in Drosophila...

journal_title：Neuron

authors： Olsen SR,Bhandawat V,Wilson RI

更新日期：2007-04-05 00:00:00

abstract：:The activation of light-dependent K+ channels in ciliary photoreceptors from Pecten was investigated using intracellular dialysis of putative messengers and modulators. Neither elevated [Ca2+] nor BAPTA changed the membrane current in the dark or the light response. IP3 and the antagonists heparin and decavanadate wer...

journal_title：Neuron

authors： del Pilar Gomez M,Nasi E

更新日期：1995-09-01 00:00:00

abstract：:The prefrontal cortex (PFC) and anterior cingulate cortex (ACC) have both been implicated in cognitive control, but their relative roles remain unclear. Here we recorded the activity of single neurons in both areas while monkeys performed a task that required them to switch between trials in which they had to look tow...

journal_title：Neuron

authors： Johnston K,Levin HM,Koval MJ,Everling S

更新日期：2007-02-01 00:00:00

abstract：:A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development. Here, we demonstrate that Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and...

journal_title：Neuron

authors： D'Arcangelo G,Homayouni R,Keshvara L,Rice DS,Sheldon M,Curran T

更新日期：1999-10-01 00:00:00

abstract：:Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus...

journal_title：Neuron

authors： Woods NI,Stefanini F,Apodaca-Montano DL,Tan IMC,Biane JS,Kheirbek MA

更新日期：2020-07-08 00:00:00

abstract：:Opioid neuropeptides and their receptors are evolutionarily conserved neuromodulatory systems that profoundly influence behavior. In dorsal striatum, which expresses the endogenous opioid enkephalin, patches (or striosomes) are limbic-associated subcompartments enriched in mu opioid receptors. The functional implicati...

journal_title：Neuron

authors： Banghart MR,Neufeld SQ,Wong NC,Sabatini BL

更新日期：2015-12-16 00:00:00

abstract：:In this perspective I tell the story (albeit a clearly abridged version) of how our knowledge of ion conduction through ion channels has evolved from a purely electrical concept to a structural dynamics view of ions interacting with a membrane protein. Our progress in this field has shown steady growth over the years ...

journal_title：Neuron

authors： Bezanilla F

更新日期：2008-11-06 00:00:00

abstract：:Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis. Inhibiting polyamine synthesis blocks the cAMP effect on regeneration. Eithe...

journal_title：Neuron

authors： Cai D,Deng K,Mellado W,Lee J,Ratan RR,Filbin MT

更新日期：2002-08-15 00:00:00

abstract：:The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...

journal_title：Neuron

authors： Smith AP,Stephan KE,Rugg MD,Dolan RJ

更新日期：2006-02-16 00:00:00

abstract：:Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I...

journal_title：Neuron

authors： Feldman DE

更新日期：2000-07-01 00:00:00

abstract：:We examined context-dependent encoding of speech in children with and without developmental dyslexia by measuring auditory brainstem responses to a speech syllable presented in a repetitive or variable context. Typically developing children showed enhanced brainstem representation of features related to voice pitch in...

journal_title：Neuron

authors： Chandrasekaran B,Hornickel J,Skoe E,Nicol T,Kraus N

更新日期：2009-11-12 00:00:00

abstract：:Nematode degenerins have been implicated in touch sensitivity and other forms of mechanosensation. Certain mutations in several degenerin genes cause the swelling, vacuolation, and death of neurons, and other mutations in the muscle degenerin gene unc-105 cause hypercontraction. Here, we confirm that unc-105 encodes a...

journal_title：Neuron

authors： García-Añoveros J,García JA,Liu JD,Corey DP

更新日期：1998-06-01 00:00:00

abstract：:Presynaptic neurexins (Nrxs) and type IIa receptor-type protein tyrosine phosphatases (RPTPs) organize synapses through a network of postsynaptic ligands. We show that leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) differentially engage the protein domains of Nrx but require its heparan sulfate (HS) modi...

journal_title：Neuron

authors： Roppongi RT,Dhume SH,Padmanabhan N,Silwal P,Zahra N,Karimi B,Bomkamp C,Patil CS,Champagne-Jorgensen K,Twilley RE,Zhang P,Jackson MF,Siddiqui TJ

更新日期：2020-04-08 00:00:00

abstract：:Conditioned place preference (CPP) is a widely used model of addiction-related behavior whose underlying mechanisms are not understood. In this study, we used dual site silicon probe recordings in freely moving mice to examine interactions between the hippocampus and nucleus accumbens in cocaine CPP. We found that CPP...

journal_title：Neuron

authors： Sjulson L,Peyrache A,Cumpelik A,Cassataro D,Buzsáki G

更新日期：2018-06-06 00:00:00

abstract：:Neuroscientific findings are rarely translated into public policies that improve the health and well-being of people experiencing serious disorders. I advocate here for investment in policymaker-scientist networks dedicated to such translation for a range of diseases. ...

journal_title：Neuron

authors： Humphreys K

更新日期：2019-09-25 00:00:00

abstract：:In stable environments, decision makers can exploit their previously learned strategies for optimal outcomes, while exploration might lead to better options in unstable environments. Here, to investigate the cortical contributions to exploratory behavior, we analyzed single-neuron activity recorded from four different...

journal_title：Neuron

authors： Donahue CH,Seo H,Lee D

更新日期：2013-10-02 00:00:00

abstract：:In this issue of Neuron, Rinberg et al. show that mice use a speed-accuracy tradeoff in odor discrimination. Shorter sampling results in high performance for easy problems, and enforced longer sampling results in higher accuracy for difficult problems, but mice freely choose intermediate sampling durations and accurac...

journal_title：Neuron

authors： Kay LM,Beshel J,Martin C

更新日期：2006-08-03 00:00:00

abstract：:Melanin-concentrating hormone (MCH)-expressing neurons are key regulators of energy and glucose homeostasis. Here, we demonstrate that they provide dense projections to the median eminence (ME) in close proximity to tanycytes and fenestrated vessels. Chemogenetic activation of MCH neurons as well as optogenetic stimul...

journal_title：Neuron

authors： Jiang H,Gallet S,Klemm P,Scholl P,Folz-Donahue K,Altmüller J,Alber J,Heilinger C,Kukat C,Loyens A,Müller-Fielitz H,Sundaram S,Schwaninger M,Prevot V,Brüning JC

更新日期：2020-07-22 00:00:00

abstract：:The brain mechanisms underlying visual object categorization remain unclear. In this issue of Neuron, Minamimoto and colleagues introduce a novel task that associates each category with a different incentive value, and they demonstrate that it can be learned within a single session even after ablation of the lateral p...

journal_title：Neuron

authors： Buckley MJ,Sigala N

更新日期：2010-05-27 00:00:00

abstract：:Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem ce...

journal_title：Neuron

authors： Hanoun M,Maryanovich M,Arnal-Estapé A,Frenette PS

更新日期：2015-04-22 00:00:00

abstract：:Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilateral...

journal_title：Neuron

authors： Dougherty KJ,Zagoraiou L,Satoh D,Rozani I,Doobar S,Arber S,Jessell TM,Kiehn O

更新日期：2013-11-20 00:00:00

abstract：:Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot...

journal_title：Neuron

authors： Giniger E

更新日期：1998-04-01 00:00:00

abstract：:Brandon et al. (2014) show that the formation of place cell representations in new environments is preserved under septal inactivation, and is thus likely independent of the hippocampal theta rhythm and, by implication, the firing of entorhinal grid cells and the process of path integration. ...

journal_title：Neuron

authors： Hayman R,Burgess N

更新日期：2014-05-21 00:00:00

abstract：:Sequential neural activity patterns are as ubiquitous as the outputs they drive, which include motor gestures and sequential cognitive processes. Neural sequences are long, compared to the activation durations of participating neurons, and sequence coding is sparse. Numerous studies demonstrate that spike-time-depende...

journal_title：Neuron

authors： Fiete IR,Senn W,Wang CZ,Hahnloser RH

更新日期：2010-02-25 00:00:00

abstract：:Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limit...

journal_title：Neuron

authors： Mennerick S,Matthews G

更新日期：1996-12-01 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamica...

journal_title：Neuron

authors： Zolles G,Wenzel D,Bildl W,Schulte U,Hofmann A,Müller CS,Thumfart JO,Vlachos A,Deller T,Pfeifer A,Fleischmann BK,Roeper J,Fakler B,Klöcker N

更新日期：2009-06-25 00:00:00

abstract：:Argiotoxin, a component of the spider venom from Argiope lobata, blocks AMPA receptor channels expressed in homomeric and heteromeric configuration in Xenopus oocytes. Argiotoxin acts as an open channel blocker in a voltage-dependent manner and discriminates between the functionally diverse AMPA receptors. Importantly...

journal_title：Neuron

authors： Herlitze S,Raditsch M,Ruppersberg JP,Jahn W,Monyer H,Schoepfer R,Witzemann V

更新日期：1993-06-01 00:00:00

abstract：:Social environment modulates learning through unknown mechanisms. Here, we report that a pheromone mixture that signals overcrowding inhibits C. elegans from learning to avoid pathogenic bacteria. We find that learning depends on the balanced signaling of two insulin-like peptides (ILPs), INS-16 and INS-4, which act r...

journal_title：Neuron

authors： Wu T,Duan F,Yang W,Liu H,Caballero A,Fernandes de Abreu DA,Dar AR,Alcedo J,Ch'ng Q,Butcher RA,Zhang Y

更新日期：2019-12-18 00:00:00