Abstract：
:The formation of topographic neural maps relies on the coordinate assignment of neuronal cell body position and axonal trajectory. The projection of motor neurons of the lateral motor column (LMC) along the dorsoventral axis of the limb mesenchyme constitutes a simple topographic map that is organized in a binary manner. We show that LIM homeodomain proteins establish motor neuron topography by coordinating the mediolateral settling position of motor neurons within the LMC with the dorsoventral selection of axon pathways in the limb. These topographic projections are established, in part, through LIM homeodomain protein control of EphA receptors and ephrin-A ligands in motor neurons and limb mesenchymal cells.
journal_name
Neuronjournal_title
Neuronauthors
Kania A,Jessell TMdoi
10.1016/s0896-6273(03)00292-7subject
Has Abstractpub_date
2003-05-22 00:00:00pages
581-96issue
4eissn
0896-6273issn
1097-4199pii
S0896627303002927journal_volume
38pub_type
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