Abstract：
:To investigate the role of the entorhinal cortex in memory at a molecular level, we developed transgenic mice in which transgene expression was inducible and limited to the superficial layers of the medial entorhinal cortex, pre- and parasubiculum. We found that expression of a constitutively active mutant form of CaMKII in these structures disrupted spatial memory formation. Immediate post-training activation of the transgene disrupted previously established memory while transgene activation 3 weeks following the training was ineffective. These results demonstrate that, similar to the hippocampus, the entorhinal cortex plays a time-limited role in spatial memory formation but is not a final cortical repository of long-term memory. Moreover, these results suggest that the indiscriminate activation of CaMKII is able to disrupt preexisting memories, possibly by altering the pattern of synaptic weight changes that are thought to form the basis of the memory trace.
journal_name
Neuronjournal_title
Neuronauthors
Yasuda M,Mayford MRdoi
10.1016/j.neuron.2006.03.035subject
Has Abstractpub_date
2006-04-20 00:00:00pages
309-18issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(06)00261-3journal_volume
50pub_type
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